2Z73,2ZIY


Conserved Protein Domain Family
7tmA_Melanopsin-like

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cd15083: 7tmA_Melanopsin-like 
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vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.
Statistics
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PSSM-Id: 320211
View PSSM: cd15083
Aligned: 11 rows
Threshold Bit Score: 371.281
Threshold Setting Gi: 229275717
Created: 11-Nov-2008
Updated: 26-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2ZIY: Todarodes pacificus rhodopsin binds retinal, contacts at 4A.
    View structure with Cn3D
  • Structure:2Z73: Todarodes pacificus rhodopsin binds retinal, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #                       #  
2Z73_A         35 YSLGIFIGICGIIGCGGNGIVIYLFTKTKSlq-tpANMFIINLAFSDFTFSLVNgfPLMTISCFLkkWIFGfaaCKVYGF 113
2ZIY_A         34 YSLGIFIGICGIIGCGGNGIVIYLFTKTKSlq-tpANMFIINLAFSDFTFSLVNgfPLMTISCFLkkWIFGfaaCKVYGF 112
gi 13632136    71 YTLGTVILLVGLTGMLGNLTVIYTFCRSRSlr-tpANMFIINLAVSDFLMSFTQa-PVFFTSSLYkqWLFGetgCEFYAF 148
gi 229289132  717 TVFGVLILLAGLTGVLGNGLALQAFYACKAlr-kpKHYLVVNLSITDGLLCVVFc-PVTVWASFAhsWTFGkpgLDMIGF 794
gi 229271211   32 LVFGSMMLVFGLIGVVGNAVALYAFCSTRKlr-rpKNYVVANLCLTDLIMCIVYc-PVIVISSFSgrIPTDg-aCTMEGF 108
gi 321473063  123 VVMGLIVSIIGIFGLVANGMVLFIFSRFKRlrsppANTFIINLAFSDMSASILH--SMAAYSNFNgrWAFGrlgCELYAM 200
gi 443731842   17 SLIGACLIILFVLAMVGNGLIIFAFLRFQDlr-iqCYILIVNLAVADFLMTTLGl-PLTIYSAFSprWPFSnsvCQLYGF 94
gi 129193      51 KILTAYMIMIGMISWCGNGVVIYIFATTKSlr-tpANLLVINLAISDFGIMITNt-PMMGINLYFetWVLGpmmCDIYAG 128
gi 501418497   80 LAIGITMSIMGFVAITTNTFVMFVFLRFRSlr-tpGNLLVVNLAFSDSMLALLGf-PLYAASSFIghWSFGkigCNFYGF 157
gi 229275717   39 YSLGTFVLVVGIVGWMGNLLIIYVFFRSKHfh-rtKNVLTLNLAITNALMCVATv-PTFVASSFSrkWIFSdtvCQMTGF 116
gi 321472649   55 ITLGVLLALIVLFGVAANSTILYVFSRFKRlr-tpANVFIINLTICDFFACCLH--PLAVYSAFRgrWSFGqtgCNLYGM 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #   #                                                                         
2Z73_A        114 IGGIFGFMSIMTMAMISIDRYNVIGRPmaas--------kkmsHRRAFIMIIFVWLWSVLWAIGPi-FGWGAYTLEGVLC 184
2ZIY_A        113 IGGIFGFMSIMTMAMISIDRYNVIGRPmaas--------kkmsHRRAFIMIIFVWLWSVLWAIGPi-FGWGAYTLEGVLC 183
gi 13632136   149 CGALFGISSMITLTAIALDRYLVITRPlatf--------gvasKRRAAFVLLGVWLYALAWSLPPf-FGWSAYVPEGLLT 219
gi 229289132  795 SVGVMVIVLMTTQLAIAVQRLAVSIKPlkaa--------vyitHGRMLLTAATTWIYSALLMLPPl-LGWNRFILDHSGV 865
gi 229271211  109 VVGMASIASVGSLVAIAVERFFSITRPmksl--------tiltKRTFLGGVAVVWLYSLILVIPPl-LGWGRYVREETKL 179
gi 321473063  201 GVGFFGFVSILTFSAIACERCLVIAGPatrsavgladghwkvsRTQAQKVCAFIWLHCAILVSMPf-FGWSSYVPEGMLT 279
gi 443731842   95 SGGLFGLTSINTQAAIAIDRCLVLIRSqkaqp-------vrrsHRQTAFVVAIPWLYAFLWSVPPl-YGWNGYRLDELQT 166
gi 129193     129 LGSAFGCSSIWSMCMISLDRYQVIVKGmagr---------pmtIPLALGKIAYIWFMSSIWCLAPa-FGWSRYVPEGNLT 198
gi 501418497  158 SGASFGLMSINTMAAIAVDRYLVIVRPymsi--------rrisYSQAYIMLGIVWVNAIGWSVPPl-VGWSRYILEGLGT 228
gi 229275717  117 MAGWFGTQSICTLAAIALDRCIAITLPmtgk---------lsrGRRAIISIVVVWLWSLVWCLPPf-FGWNKWSMQKYQT 186
gi 321472649  132 GVAFFGLNSIVTLSAIACERYIVITSSscrpvv----akwritRRQAQRACVAIWIHCAALVSPPllFGWSTYLPEGVLV 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ###                ##   #                                                       
2Z73_A        185 NCSFDYisrdstTRSNILCMFILGFFGPILIIFFCYFNIVMSVsnhekemaamakr------lnakelrkaqagaNAEMR 258
2ZIY_A        184 NCSFDYisrdstTRSNILCMFILGFFGPILIIFFCYFNIVMSVsnhekemaamakr------lnakelrkaqagaNAEMR 257
gi 13632136   220 SCSWDYmsftpaVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIretgralqtfgac------kgngeslwqrqrlQSECK 293
gi 229289132  866 SVTFDYlarddlSRLYVIVLLIFAFALPLVGIVCSYSYIVVAVrrsrqkak----------------vpttestcKRDTK 929
gi 229271211  180 SCSFDYlstddaNRSYVIWLVIVAFGLPLLVIAYCYISVFITVkkctkkrk----------------lmsphkksRSEVK 243
gi 321473063  280 SCSWDYttktaaNRAYYILLLTTGFLLPLMLICASYGRIMASVvwharqmvcin----------sqnsafrklrrQTEIR 349
gi 443731842  167 ICSFDIvaesfsSRVFVVCVGVFGFLLPLCIIIFCYSFIFVAInkykkgfyeisesl----rfsvyigsavvphpKRDYK 242
gi 129193     199 SCGIDYlerdwnPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVsahekamreqakkm-----nvkslrssedaekSAEGK 273
gi 501418497  229 TCTFDYlsrdpvTRTYLVSLYVGGFVIPVLLIVYCYTYIFLRVrqhekafartskrm-----ktryirgakeatrRADVK 303
gi 229275717  187 GCTFNYlsdntfQRWYIMALTLAVFVLPMVVMIVCYYAIWRAArrstlalkgmmd--------lgsfqnlpkkrrNVDVH 258
gi 321472649  208 TCSWDYtsrttsNRLYYFYLLFFGFVLPVSVLTFCYVAIFRFIvrssremtrlimtsdgrasfskttvsfrkrrrQTDVR 287
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                        #   #                                #                     
2Z73_A        259 LAKISIVIVSQFLLSWSPYAVVALLAqfgp------lewvTPYAAQLPVMFAKASAIHNPMIYSVSHpkFREAI 326
2ZIY_A        258 LAKISIVIVSQFLLSWSPYAVVALLAqfgp------lewvTPYAAQLPVMFAKASAIHNPMIYSVSHpkFREAI 325
gi 13632136   294 MAKIMLLVILLFVLSWAPYSAVALVAfagy------ahvlTPYMSSVPAVIAKASAIHNPIIYAITHpkYRVAI 361
gi 229289132  930 TAIVALGLSALFCASWTPYAIVVLLSlfn--------vtvPIIYIMVASAIAKCSCTVNPVMFALTLpvVRQYY 995
gi 229271211  244 TAVNAFIMTTAFCLCWCPYAVVATMGisg--------ssvQGTVVFGAALLAKLSVLINPVAYVFSIpsFRKAL 309
gi 321473063  350 TAQIVVTLILVYLTAWTPYAIVTLIGqfgse-----dshlSPMATAIPAYFAKTAVVLDPLVYGFSHphFRNSL 418
gi 443731842  243 TAQIGLTCVIFFCLAWMPYAVVGWISvagy------ynkvGPHVLLMTTLFAKTSTIYNPTIYAACLprFRRRV 310
gi 129193     274 LAKVALVTITLWFMAWTPYLVINCMGlfkf-------eglTPLNTIWGACFAKSAACYNPIVYGISHpkYRLAL 340
gi 501418497  304 TARTGFLAVIVFCIAWSPYAVMALVGqfgd------qdllTPIVSAIPGILAKSSTIYNPMIFAVSHprFRRKL 371
gi 229275717  259 TAKVGVLVTLLFILSWTPFAIVALIGwagy------ghvlTPLAGAIPAAIAKMSVVVNYVVYAALMpdFKRGR 326
gi 321472649  288 TALIILSLAMLCYTAWTPYAIVSLIGqfgpvdedgqpkklSPMATAIPAFLAKTAIVFDPLVYGFSHpqFRSSV 361

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