Conserved Protein Domain Family
7tmA_tmt_opsin

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cd15086: 7tmA_tmt_opsin 
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors
Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.
Statistics
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PSSM-Id: 320214
View PSSM: cd15086
Aligned: 7 rows
Threshold Bit Score: 420.298
Threshold Setting Gi: 47225327
Created: 17-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 74095897   40 LVVSVFLGFIGTFGLVNNLLVLVLFCRYKMlrspINLLLMNISISDLLVCVLGTPFSFAASTQGRWLIGeagCVWYGFAN 119
gi 68374327   79 TVTAVCLGAILLLGCLNNLFVLLVFARFRTlwtpINLILLNISVSDILVCLFGTPFSFASSLYGKWLLGhhgCKWYGFAN 158
gi 169646828  41 ILVAVSLGFIGTFGFLNNLLVLVLFGRYKVlrspINFLLVNICLSDLLVCVLGTPFSFAASTQGRWLIGdtgCVWYGFAN 120
gi 47225327    3 TAVAVLLGVILVAGILSNSLVLLLFVKYRSlwtpINLILLNINLSDILVCVFGTPFSFAASLQGRWLIGeggCMWYGFAN 82
gi 482660175  30 TVVAVFLGFILFFGFLNNLIVLILFCKFKTlrnpVNMLLLNISISDMLVCISGTTLSFASNIHGKWIGGehgCRWYGFVN 109
gi 482660177  32 TIVAVFLGIILIFGSISNFIVLVLFCKFKVlrnpVNMLLLNISISDMLVCLSGTTLSFASSIQGRWIGGkhgCRWYGFAN 111
gi 512866834  53 LLVAVFLGVIGSLGFFNNLVVLILFCQYKVlrspINMLLMNISLSDLMVCILGTPFSFAASTQGHWLIGeigCIWYGFVN 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                               ####        
gi 74095897  120 SLFGVVSLISLAVLSFERYSTMMTPteaDPSNYCKVCLGITLSWVYSLVWTVPPLFGWSSYGPEgpgTTCSVNWtakttn 199
gi 68374327  159 SLFGIVSLMSLSILSYERYAALLRAtkaDVSDFRRAWLCVAGSWLYSLLWTLPPFLGWSNYGPEgpgTTCSVQWhlrsts 238
gi 169646828 121 SLLGIVSLISLAVLSYERYCTMMGSteaDATNYKKVIGGVLMSWIYSLIWTLPPLFGWSRYGPEgpgTTCSVDWttktan 200
gi 47225327   83 SLFGIVSLVSLSVLSYERCTVVLQPsqvDVSDFRKARFCVGGSWLYALLWTSPPLLGWSSYGPEgagTTCSVQWqlrspa 162
gi 482660175 110 SCFGIVSLISLAVLSYERYSTLTLCn-kRSDDYRKALLAVGGSWVYSLLWTVPPLLGWSSYGIEgagTSCSVRWssetae 188
gi 482660177 112 SCFGIVSLISLAILSYERYRTLTLCp-gQGADYQKALLAVAGSWLYSLVWTVPPLIGWSSYGTEgagTSCSVHWtsksve 190
gi 512866834 133 TLFGTVSLVSLAVLSYERYCTMLRSteaDLTNYKKAWLGILVSWIYSLVWTLPPLFGWSKYGPEgpgTTCSVNWhsrdan 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ##   #                                                  #   #            
gi 74095897  200 SISYIICLFVFCLIVPFLVIVFCYGKLLCAIRqvsginastsrKREQRVLCMVVIMVICYLLCWLPYGVVALLATFGppd 279
gi 68374327  239 SISYVMCLFIFCLLLPLVLMIFCYGKILLLIKgvtkinlltaqRRENHILLMVVTMVSCYLLCWMPYGVVALLATFGrtg 318
gi 169646828 201 NISYIICLFIFCLIVPFLVIIFCYGKLLHAIKqvssvntsvsrKREHRVLLMVITMVVFYLLCWLPYGIMALLATFGapg 280
gi 47225327  163 SVSYVLCLLVFCLLLPFLVMVYSYGRILVAIRrvgrinqltaqRREQHILLMVLSMVSCYMLCWMPYGIMALVATFGklg 242
gi 482660175 189 STSYIICLFIFCLVIPVMVMMYCYGRLLYAVKqvgkihkntarKREYHVLFMVITTVICYLVCWIPYGVIALLATFGkpg 268
gi 482660177 191 SVSYIMCLFIFCLVIPILVMVYFYGRLLYAVKqvgkirktaarKREYHVLFMVVTAVICYLICWVPYGMIALLATFGppg 270
gi 512866834 213 NISYIVCLFIFCLALPFAVIVYCYGRLLFAIKqvsgvsksssrAREQRVLIMVIVMVVCFLLCWLPYGVMALVATFGkpg 292
                        250       260       270
                 ....*....|....*....|....*....|....*.
Feature 1                  #   #                     
gi 74095897  280 lvTPEASIIPSVLAKSSTVINPIIYVFMNkQFYRCF 315
gi 68374327  319 liTPVTSIVPSVLAKSSTVVNPVIYVLFNnQFYRCF 354
gi 169646828 281 lvTAEASIVPSILAKSSTVINPVIYIFMNkQFYRCF 316
gi 47225327  243 lvTPMVSVVPSILAKFSTVVNPIIYMFFNnQEKLSP 278
gi 482660175 269 vvTPVASIIPSILAKSSTVCNPIIYILMNkQFYKCF 304
gi 482660177 271 vvSPVANVVPSILAKSSTVCNPIIYVLMNkQFYKCF 306
gi 512866834 293 iiSPSASIIPSVLAKSSTVYNPIIYIFLNkQFYRCF 328

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