4EA3,5DHG,5DHH


Conserved Protein Domain Family
7tmA_NOFQ_opioid_R

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cd15092: 7tmA_NOFQ_opioid_R 
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nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.
Statistics
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PSSM-Id: 320220
View PSSM: cd15092
Aligned: 7 rows
Threshold Bit Score: 475.896
Threshold Setting Gi: 45387607
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Structure:4EA3: Human nociceptin/orphanin FQ receptor in complex with a peptide mimetic antagonist (C-24), contacts at 4A
    View structure with Cn3D
  • Structure:5DHG: Human nociceptin/orphanin FQ receptor in complex with an antagonist (C-35), contacts at 4A
    View structure with Cn3D
  • Structure:5DHH: Human nociceptin/orphanin FQ receptor in complex with an antagonist (Sb-612111), contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##           ###### ##
4EA3_A       126 VTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTaTNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNalCKTVIAIDY 205
gi 730230     52 VTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTaTNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNalCKTVIAIDY 131
gi 449274197  50 ITIVVVYSIVCIVGLVGNCSVMYVIVRFTKMKTaTNIYIFNLALADTLCLMTLPFQGTDTFLGfWPFGNvlCKIAISIDY 129
gi 148223886  44 VTIVVVYLIVCVVGLVGNCAVMYVIVRYTKMKTaTNIYIFNLALADALVLVTLPFQGTDIFMGiWPFGNvlCKIAIAIDY 123
gi 45387607   44 ITIAVVYMIVCVVGLVGNCLVMYVIIRYTKMKTaTNIYIFNLALADALVLATLPFQGTDVFLGfWPFGNalCKVVVSIDY 123
5DHG_A       126 VTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTaTNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNalCKTVIAIDY 205
5DHH_A       126 VTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTaTNIYIFNLALADTLVLLTLPFQGTDILLGfWPFGNalCKTVIAIDY 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                            # #####                          
4EA3_A       206 YNMFTSTFTLTAMSVDRYVAICHPirALDVRtSSKAQAVNVAIWALASVVGVPVAIMGsa-qvEDEEIECLVeiptpqDY 284
gi 730230    132 YNMFTSTFTLTAMSVDRYVAICHPirALDVRtSSKAQAVNVAIWALASVVGVPVAIMGsa-qvEDEEIECLVeiptpqDY 210
gi 449274197 130 YNMFTSTFTLTMMSVDRYIAICHPikALDIRtPHKAKVVNVCIWALASVFGIPAMVMGsa-enENNEIDCLIklpspvDY 208
gi 148223886 124 YNMFTSTFTLTMMSVDRYIAICHPvkALDIRtPHKAKVINVCIWILASFIGIPVMVMGsa-emENDEIECLVqipppeHY 202
gi 45387607  124 YNMFTSVFTLTVMSMDRYVAVCHPvkALDMRtPHKAKVVNICVWVLASAIGVPAMVLGdveqdNGESIECILvlpdprSY 203
5DHG_A       206 YNMFTSTFTLTAMSVDRYVAICHPirALDVRtSSKAQAVNVAIWALASVVGVPVAIMGsa-qvEDEEIECLVeiptpqDY 284
5DHH_A       206 YNMFTSTFTLTAMSVDRYVAICHPirALDVRtSSKAQAVNVAIWALASVVGVPVAIMGsa-qvEDEEIECLVeiptpqDY 284
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ### ### ##                                                   #  ## ##  #    
4EA3_A       285 WGPVFAICIFLFSFIVPVLVISVCYSLMIRRLrgvrllsgsreKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQglgv 364
gi 730230    211 WGPVFAICIFLFSFIVPVLVISVCYSLMIRRLrgvrllsgsreKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQglgv 290
gi 449274197 209 WDPVFGICVFLFSFMIPVLIITICYSLMIRRLknvrvlsgskeKDRNLRRITRMVLVVVAVFIICWTPIQIFVLVQclga 288
gi 148223886 203 WDPVFGICVFLFSFVIPVLIITICYSLMIRRLkkvrvlsgskeKDRNLRRITRLVMVVVAVFIICWTPIQIFVLVQslga 282
gi 45387607  204 WDPVFGTCVFLLSFLIPVAIISVCYSLMVKRLrsvrilsgskeKDRNLRRITRMVLVVVAAFVVCWTPIQIMALAQslgf 283
5DHG_A       285 WGPVFAICIFLFSFIVPVLVISVCYSLMIRRLrgvrllsgsreKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQglgv 364
5DHH_A       285 WGPVFAICIFLFSFIVPVLVISVCYSLMIRRLrgvrllsgsreKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQglgv 364
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
Feature 1              ## ###  #  ##                     
4EA3_A       365 qpssetAVAILRFCTALGYVNSCLNPILYAFLDeNFKACF 404
gi 730230    291 qpssetAVAILRFCTALGYVNSCLNPILYAFLDeNFKACF 330
gi 449274197 289 kaeselELAISCFCTALGYANSSLNPVLYAFLDeNFKACF 328
gi 148223886 283 kpdsdlKVAILHFCIALGYVNSSLNPVLYAFLDeNFKACF 322
gi 45387607  284 nlasvqTVVFMHFCIALGYVNSSLNPVLYAFLDeNFKRCF 323
5DHG_A       365 qpssetAVAILRFCTALGYVNSCLNPILYAFLDeNFKACF 404
5DHH_A       365 qpssetAVAILRFCTALGYVNSCLNPILYAFLDeNFKACF 404

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