Conserved Protein Domain Family
7tmA_AstA_R_insect

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cd15096: 7tmA_AstA_R_insect 
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors
The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.
Statistics
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PSSM-Id: 320224
View PSSM: cd15096
Aligned: 13 rows
Threshold Bit Score: 321.167
Threshold Setting Gi: 443692401
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 75018194   43 RVVPIFFGFIGIVGLVGNALVVLVVAANPGmrstTNLLIINLAVADLLFVIFCVPFTATDYvmprWPFGdwwCKVVQYFI 122
gi 7242702    47 IIVPTIFGVICILGLFGNSLVILVVVSDKHmrntTNILILSLAVADLLFILFCVPFTAHGYalpvWPFGdigCKMTQYAM 126
gi 17570665   44 IIIPTIFAVIILVGLVGNALVVIVAFGRQMrn-sTNTLIIGLAISDLMFLLLCVPFTAVDYaaptWIFPewtCSMINFFQ 122
gi 321464139   3 LKVPIIFGIIVVVGFIGNALVVVVVAANQQmrntTNLLIINLALADLLFIVFCVPFTASDYalpfWPFGdawCKIVQYLV 82
gi 17864278   75 TIVPVFFGIIGFAGLLGNGLVILVVVANQQmrstTNLLIINLAVSDILFVIFCVPFTATDYvlpeWPFGnvwCKFVQYMI 154
gi 215491444  96 IVVPILFGAIAVVGFFGNALVVLVVLCNPQmrstTNILIINLAMADLLFIVFCVPFTGWDYtlnyWPFGdvwCRIVQYLV 175
gi 358333960 139 YVTPVLFGLYFILGFVGNLFVIIVILANAQmrntTNILVFSLAIADMTLVILCIPPTGAVYltgtWPLGnvmCHIFWYST 218
gi 360044213  70 IVTPVVFGLILIIGFVGNLFVMIVVLANAQmrntTNILIFSLAVADMAFIVICVPSAAIVYvagkWPLGlslCRIYYYSS 149
gi 386766685  39 WIVGFFFGVIAITGFFGNLLVILVVVFNNNmrstTNLMIVNLAAADLMFVILCIPFTATDYmvyyWPYGrfwCRSVQYLI 118
gi 443691914  35 VTVPLLFGIITLIGVIGNSLVIYVILSRKRmhsvTNILLLNLAVADLSFVMVIPPFTAYQFaksqWPFGdavCKLMHYLV 114
gi 443725415   4 YVGPSIFGLIFVVGVIGNSLVITVILSKQSmrtvTNFLLLNLAVADMAFLVVCIPFTAHKFitmkWIFGdtaCKVVQYFV 83
gi 443731118  60 VLVPAIVTFVVISGLLGNVLVIYVISSRKHlqtvTNILLMNLAISDVSFLLICGSFTAVYYvlpdWPLGdalCRIVQYLL 139
gi 443692401   1 LVIPFLFGMVSIIGLIGNSLVVFVILTEAKmrttVNLLLLNLAFSDIIFSGICVPFVTYHFvaenWLIGdvaCKLLNFFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 75018194  123 VVTAHASVYTLVLMSLDRFMAVVHPiaSMSIRtEKNALLAIACIWVVILTTAIPVGIchgerey------syfnrnhSSC 196
gi 7242702   127 YVCAYASVYTLVIMPLDRYLAVVHAirSMTLRsERNTWFAIPIIWIIILCGNTPILLqfgvfny------vhegenrSAC 200
gi 17570665  123 HTSAYCSVWTLTLMALDRYLAVVYPveSMTLRtPRNTVIALCFIYIIIIASQIPVGRmhgiyvy------dfimekrSTC 196
gi 321464139  83 IVTAYASVYTLVLMSLDRYLAVVHPitSMSIRtEANTYWAIAVTWVVIFVACVPLLMahgevmy------lfaeeeySVC 156
gi 17864278  155 VVTCHCSVYTLVLMSFDRFLAVVHPvtSMSLRtERNATLAIMCAWITIVTTAIPVALshsvriy------qyhgnagTAC 228
gi 215491444 176 IVCAYASIYTLVLMSFDRFLAVVHPitSMSIRtERNAYIAIFLTWVVILLACVPALFshgmvf---------lddnySSC 246
gi 358333960 219 YVSIYCIAYTLLLMSLDRFLAVVYPmkFAAFRkQGNMLKAVVAIWIITMISNISLLFnsmivygsa--eggdspcatRYC 296
gi 360044213 150 YVSVYCSVYTLVLMSLDRFVAVVYPiqCMHIRtQKNTTIAVLITWTVVLVTNIPLFIgailvkgpp--eggesscvtEYC 227
gi 386766685 119 VVTAFASIYTLVLMSIDRFLAVVHPirSRMMRtENITLIAIVTLWIVVLVVSVPVAFthdvvvdy----dakknityGMC 194
gi 443691914 115 NVTAYVTVYTLVLISAIRYMTIVHHtaTAQLRtKRKVILMIIGIWSLMLLLNSPVMVvyssqs---------vsatvSDC 185
gi 443725415  84 YVTAYITVYTLVAISALRYMTIVWStqTQFIRtKRNVIAFIVSIWTVTFGANIPVMLlhevky---------psaavSYC 154
gi 443731118 140 YVSAYVTVYTLTAVSAVRYVTVLYGskAVFIRsKRNIVLLAVGIWVVFLVAKIPILVvhgvsh--------nhltqrTTC 211
gi 443692401  81 YVCVYVTVYTLVGISVVRYMAVVYSngSSRIRtKRNICMAVGVLWAVMLIINCPMLFlyrvksitqelengqasppyYYC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             #  ### ### ##                                              
gi 75018194  197 VFleer------------gysKLGFQMSFFLSSYVIPLALISVLYMCMLTRLwksapgg-------------------rv 245
gi 7242702   201 LNlkelk----------eheaGKAFFGSFLFFGYVIPLGVTMLMYGLMLKRLlygvvpgg-----------------gnq 253
gi 17570665  197 AIltiata-------eatptmARTYFMTFNVFGYVLPLGISVVLYGLMLRKLwdmprpgnsqsvggrnltnrdsgssirr 269
gi 321464139 157 VFlqke------------gwsYHVFQITFFATSYVIPLLLICGLYICMLMRLwrgvapgg------------------rv 206
gi 17864278  229 VFstee-----------eiwsLVGFQVSFFLSSYVAPLTLICFLYMGMLARLwksapgc-------------------kp 278
gi 215491444 247 TFlaem------------gysLAAFQICFFMFSFVVPLALIFILYVLMLKRLwfgvtpgg------------------rv 296
gi 358333960 297 TYswlvqidpttgiakdnftgAQIYFTLFFLFGYLIPFTLITGLYITVIFRLrcrksphi------------------kp 358
gi 360044213 228 TYswlvnfdaytniardnrqgGQMFFLLFFLFGYLFPFVVICLLYICLILRLrygpsskm------------------ar 289
gi 386766685 195 TFttnd------------flgPRTYQVTFFISSYLLPLMIISGLYMRMIMRLwrqgtgv-------------------rm 243
gi 443691914 186 NHnsl--------------saARYLFTTFFTFAYLIPLLIIGVLSVCILYYIqsqkvslvd----------------knr 235
gi 443725415 155 GLeg---------------kaVEPLFLAFFILSYALPLIAIIFLYMLILFHLrqqksm---------------------- 197
gi 443731118 212 VIsgv--------------peAQQLFASFFVFAYALPLVVIATLYLMIVCHLrrkgmh---------------------n 256
gi 443692401 161 AMkdk--------------dtGQKIFFSFFFLTYLIPLTFICTFYMLLLRYLrlqrkgssin-------------hnhrs 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                 #  ## ##  #               ## ###  #  ##                
gi 75018194  246 saesrRGRKKVTRMVVVVVVVFAVCWCPIQIILLVKalnky-----hityfTVTAQIVSHVLAYMNSCVNPVLYAFLSeN 320
gi 7242702   254 saesiRAKKRATRMVVIVVVIFAICWLPIQIILFAErfgha-----pntipHISTMFAANCLAYMNSCVNPILYAFLSeN 328
gi 17570665  270 rpeatAAKRKVTRLVLCVLITWALCWLPLNVCFFMSglaypeplvishgviMVIVQIASQVLAYTNSCLNPILYALMSqS 349
gi 321464139 207 saesrRGKKRVTRMVCIVVVIFAVCWCPIQLVLVLKslalf-----eitplTVMIQIISHVLAYMNSCVNPFLYALISdN 281
gi 17864278  279 saesrKGKRRVTRMVVVVVLAFAICWLPIHVILVLKalnly-----ggshlSVIIQIISHVVAYTNSCINPILYAFLSdN 353
gi 215491444 297 saesvRSKKRVTRLVVVVVVVFAVCWCPVQIVLVLKsvelyg---lpmnppRIVIQIASQILAYTNSCVNPFLYAFLSeN 373
gi 358333960 359 svesqRSRKRITRMVVTVVVAFGISWLPIHLIFLHQyyvgd-----pntdwYRMIQIACNCLAYGHSCVNPILYAFLStT 433
gi 360044213 290 saeaqRSKRRVTRLVVTVVIVFGISWLPIHAIFLIQyyakd-----petdlFRIIQILGNCLAYGNSSINPILYAFLSeK 364
gi 386766685 244 skesqRGRKRVTRLVVVVVIAFASLWLPVQLILLLKsldvie----tntltKLVIQVTAQTLAYSSSCINPLLYAFLSeN 319
gi 443691914 236 rtksfKKKRRASRLIILVVVIFAILWLPIHIHLLLAfyghl-----psskfYHAVSVLFNCAAYANSCVNPFIYNHASrE 310
gi 443725415 198 ldqtrDRTNHAFRIIVAVIVVFALTWLPHHVNSLVSvygvl-----paetwYQAFRVLWYCMAYGNSCANPLIYNYGSqE 272
gi 443731118 257 spssdDRKRHITKVLVLVVAVFAVCWLPLHIHLLVAyygql-----petvlYKVLLILWNTLAFLNSVLNPIIYNFCSqD 331
gi 443692401 214 srksqTKTALASKILIVVVGVFGICWLPLQLLLLISyfgvq-----segraYQVMRPLSHWLAYSNSMMNPLIYNYVSqD 288

                 ....*
Feature 1             
gi 75018194  321 FRVAF 325
gi 7242702   329 FRRSF 333
gi 17570665  350 FREGF 354
gi 321464139 282 FRKAF 286
gi 17864278  354 FRKAF 358
gi 215491444 374 FRKSF 378
gi 358333960 434 FRKAF 438
gi 360044213 365 FRAGF 369
gi 386766685 320 FRKAF 324
gi 443691914 311 FRQAF 315
gi 443725415 273 FRKSF 277
gi 443731118 332 FRLSF 336
gi 443692401 289 FRKSF 293

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