Conserved Protein Domain Family
7tmA_GPR3_GPR6_GPR12-like

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cd15100: 7tmA_GPR3_GPR6_GPR12-like 
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.
Statistics
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PSSM-Id: 320228
View PSSM: cd15100
Aligned: 5 rows
Threshold Bit Score: 412.253
Threshold Setting Gi: 1170006
Created: 21-Oct-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #               ##  ##  #
gi 1170009    73 NPWDVLLCVSGTVIAGENALVVALIASTPAlrtPMFVLVGSLATADLLAGCGLILHFVFQylvpsetvSLLTVGFLVASF 152
gi 1346168    45 NPWDIVLCTSGTLISCENAIVVLIIFHNPSlraPMFLLIGSLALADLLAGIGLITNFVFAyllqseatKLVTIGLIVASF 124
gi 1170006    41 KAWDVVLCISGTLVSCENALVVAIIVGTPAfraPMFLLVGSLAVADLLAGLGLVLHFAAVfcigsaemSLVLVGVLAMAF 120
gi 130507243  38 TPWDITLCVSGVLICCENAIVVATIFSSSSlraPMFLLIGSLAWADFLAGVGLLLHFLSRrcvysealELGSVGLLVSAL 117
gi 160420141  51 NPWDIILCVTGTVMACENAIVIAILFYTPSlraPMFILIGSLALADLLAGLGLIVNFIVIyvfnselaTLSSAGLLLAAF 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     #  
gi 1170009   153 AASVSSLLAITVDRYLSLYNAltYYSRRtLLGVHLLLAATWTVSLGLGLLPvlgWNCLAERAACSVvrPLARSHVALLSA 232
gi 1346168   125 SASVCSLLAITVDRYLSLYYAltYHSERtVTFTYVMLVMLWGTSICLGLLPvmgWNCLRDESTCSVvrPLTKNNAAILSV 204
gi 1170006   121 TASIGSLLAITVDRYLSLYNAltYYSETtVTRTYVMLALVWGGALGLGLLPvlaWNCLDGLTTCGVvyPLSKNHLVVLAI 200
gi 130507243 118 SASVFSLLGITLDRFLSLHHAltYGSQRtHTQTRCALAVGWTLAGLQGALPalgWNCLHDGDSCSVlrPLTRVHLATLCG 197
gi 160420141 131 SASVCSLLAITLDRYLSLYNAltYHTDRtLTFTYTMLILLWALCICIGLLPimgWNCFREQSSCSVlrPVTKNNAAVLAV 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #      #            #
gi 1170009   233 AFFMVFGIMLHLYVRICQVVWRHAHQIALQqhclapphlAATRKGVGTLAVVLGTFGASWLPFAIYCVVGshedPAVYTY 312
gi 1346168   205 SFLFMFALMLQLYIQICKIVMRHAHQIALQhhflatshyVTTRKGVSTLAIILGTFAACWMPFTLYSLIAdytyPSIYTY 284
gi 1170006   201 AFFMVFGIMLQLYAQICRIVCRHAQQIALQrhllpashyVATRKGIATLAVVLGAFAACWLPFTVYCLLGdahsPPLYTY 280
gi 130507243 198 GFLLTLALLLQLNARICRVVLRHSHQIALQrhtl-psarTHTRRRVHTLALILATFASCWIPFALYGLLGdgssPALYTY 276
gi 160420141 211 SFLLLFALMMQLYLQICRIAFRHAQQIAVQhqfmatsqaSSTRKGVSTLSLILGTFALCWIPFAVYSLVAdssyPMIYTY 290
                        250       260
                 ....*....|....*....|....*...
Feature 1          #                         
gi 1170009   313 ATLLPATYNSMINPIIYAFRNqeIQRAL 340
gi 1346168   285 ATLLPATYNSIINPVIYAFRNqeIQKAL 312
gi 1170006   281 LTLLPATYNSMINPIIYAFRNqdVQKVL 308
gi 130507243 277 ATLVPVTGNSLLNPLIYAYRNthIQRVL 304
gi 160420141 291 CMVLPAACNSVINPIIYAFRNpdIQKSL 318

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