Conserved Protein Domain Family
7tmA_MrgprA

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cd15105: 7tmA_MrgprA 
mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.
Statistics
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PSSM-Id: 320233
View PSSM: cd15105
Aligned: 10 rows
Threshold Bit Score: 392.957
Threshold Setting Gi: 50401108
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #  ##             ###### #
gi 50401107   14 LIPDLMIIIFGLVGLTGNAIVFWLLGFRMHrtaFLVYILNLALADFLFLLCHIINSTVDLLKFTLPKGifaFCFHTIKRV 93
gi 50401114   13 SDPKLMIIIFRLVGMTGNAIVFWLLGFSLHrnaFSVYILNLALADFVFLLCHIIDSMLLLLTVFYPNNifsGYFYTIMTV 92
gi 50401112   14 LIPNLMIIIFGLVGLTGNAIVLWLLGFCLHrnaFLVYILNLALADFLFLLCHFINSAMFLLKVPIPNGifvYCFYTIKMV 93
gi 172045710  14 LIPNLLIIISGLVGLIGNAMVFWLLGFRLArnaFSVYILNLALADFLFLLCHIIDSTLLLLKFSYPNIiflPCFNTVMMV 93
gi 50401113   10 LITNLMIVILGLVGLTGNAIVFWLLLFRLRrnaFSIYILNLALADFLFLLCHIIASTEHILTFSSPNSifiNCLYTFRVL 89
gi 50401109   14 LIPNLMIIIFGLVGLTGNGIVFWLLGFCLHrnaFSVYILNLALADFFFLLGHIIDSILLLLNVFYPITf-lLCFYTIMMV 92
gi 50401108   14 LIPKLMIIIFGLVGLMGNAIVFWLLGFHLRrnaFSVYILNLALADFLFLLSSIIASTLFLLKVSYLSIifhLCFNTIMMV 93
gi 50401111   14 LIRHLMIIIFGLVGLTGNAIVFWLLGFHLHrnaFLVYILNLALADFFYLLCHIINSIMFLLKVPSPNIildHCFYTIMIV 93
gi 550544268  22 LIPNLMIIIFGLVGLTGNVILFWLLGFHLHrnaFLVYILNLALADFLFLLCHIINSTMLLLKVHLPNNilnHCFDIIMTV 101
gi 512979643  31 LIPNLVILISGLVGLAGNSVVLWLLGFRMRrnaFSIYILNLAAADLLFLCCHIIDSLLVVVRYFHPHVfflPCYKTVMMF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                          # #####                       #  #
gi 50401107   94 LYITGLSMLSAISTERCLSVLCPIWYHCRRpEHTSTVMCAVIWVLSLLICILDGYFCgyldnhYFNYSVCqawDIFIGAY 173
gi 50401114   93 PYIAGLSMLSAISTELCLSVLCPIWYRCHHpEHTSTVMCAAIWVLPLLVCILNRYFCsfldinYNNDKQClasNFFTRAY 172
gi 50401112   94 LYITGLSMLSAISTERCLSVLCPIWYHCRRpEHTSTVMCAVIWIFSVLICILKEYFCdffgtkLGNYYVCqasNFFMGAY 173
gi 172045710  94 PYIAGLSMLSAISTERCLSVVCPIWYRCRRpKHTSTVMCSAIWVLSLLICILNRYFCgfldtkYEKDNRClasNFFTAAC 173
gi 50401113   90 LYIAGLSMLSAISIERCLSVMCPIWYRCHSpEHTSTVMCAMIWVLSLLLCILYRYFCgfldtkYEDDYGClamNFLTTAY 169
gi 50401109   93 LYIAGLSMLSAISTERCLSVLCPIWYHCHRpEHTSTVMCAVIWVLSLLICILNSYFCgflntqYKNENGClalNFFTAAY 172
gi 50401108   94 VYITGISMLSAISTECCLSVLCPTWYRCHRpVHTSTVMCAVIWVLSLLICILNSYFCavlhtrYDNDNEClatNIFTASY 173
gi 50401111   94 LYITGLSMLSAISTERCLSVLCPIWYRCHRpEHTSTAMCAVIWVMSLLISILNGYFCnfsspkYVNNSVCqasDIFIRTY 173
gi 550544268 102 LYITGLSMLSAISTERCLSVLCPIWYRCRRpEHTSTVLCAVIWFLPLLICILNGYFChffgpkYVIDSVClatNFFIRTY 181
gi 512979643 111 PYITGLSVLSAISTERCLSFLCPIWYRFRRpKHTSVTVCVLLWATSLLMCILNKSYCgll-dvNEKTAEClaaNFSTATC 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ## ### ##                                     #  ## ##  #           ## ###  #  #
gi 50401107  174 LMFLFVVLCLSTLALLARLFCGAr-nMKFTRLFVTIMLTVLVFLLCGLPWGITWFLLfwia----pgvFVLDYSPLLVLT 248
gi 50401114  173 LMFLFVVLCLSSMALLARLFCGTg-qMKLTRLYVTIMLTVLGFLLCGLPFVIYYFLLfnikd-gfclfDFRFYMSTHVLT 250
gi 50401112  174 LMFLFVVLCLSTLALLARLFCGAe-kMKFTRLFVTIMLTILVFLLCGLPWGFFWFLLiwikg-gfsvlDYRLYLASIVLT 251
gi 172045710 174 LIFLFVVLCLSSLALLVRLFCGAg-rMKLTRLYATIMLTVLVFLLCGLPFGIHWFLLiwiki-dygkfAYGLYLAALVLT 251
gi 50401113  170 LMFLFVVLCVSSLALLARLFCGAg-rMKLTRLYVTITLTLLVFLLCGLPCGFYWFLLskikn-vftvfEFSLYLASVVLT 247
gi 50401109  173 LMFLFVVLCLSSLALVARLFCGTg-qIKLTRLYVTIILSILVFLLCGLPFGIHWFLLfkikd-dfhvfDLGFYLASVVLT 250
gi 50401108  174 MIFLLVVLCLSSLALLARLFCGAg-qMKLTRFHVTILLTLLVFLLCGLPFVIYCILLfkikd-dfhvlDVNFYLALEVLT 251
gi 50401111  174 PIFLFVLLCLSTLALLARLFSGAg-kRKFTRLFVTIMLAILVFLLCGLPLGFFWFLSpwied-rfivlDYRLFFASVVLT 251
gi 550544268 182 PMFLFIVLCLSTLALLARLFCGAg-kTKFTRLFVTIMLTVLVFLLCGLPLGFFWFLVpwinr-dfsvlDYILFQTSLVLT 259
gi 512979643 190 LGVLVLILSGSSLAMLVGFLWGGgrqMRLTRLYVTILLTVLVFLLCGLPLGVYWFVLiwihddfsdtlQYGLYLASVVLS 269
                        250       260       270
                 ....*....|....*....|....*....|....*...
Feature 1        #                                     
gi 50401107  249 AINSCANPIIYFFVGSFRQRLNkqTLKMVLQKALQDTP 286
gi 50401114  251 AINNCANPIIYFFEGSFRHQLKhqTLKMVLQSVLQDTP 288
gi 50401112  252 VVNSCANPIIYFFVGSFRHRLKhqTLKMVLQSALQDTP 289
gi 172045710 252 AVNSCANPIIYFFVGSFRHQKHq-TLKMVLQRALQDTP 288
gi 50401113  248 AINSCANPIIYFFVGSFRHRLKhqTLKMVLQSALQDTP 285
gi 50401109  251 AINSCANPIIYFFVGSFRHRLKhqTLKMVLQNALQDTP 288
gi 50401108  252 AINSCANPIIYFFVGSFRHQLKhqTLKMVLQSALQDTP 289
gi 50401111  252 VVNSCANPIIYFFVGSFRHRLKqqTLKMFLQRALQDTP 289
gi 550544268 260 SVNSCANPIIYFFVGSFRHRLKhkTLKMVLQSALQDTP 297
gi 512979643 270 SVNSCANPLIYFFVGTFRQQPGrqTLKLLLQRALQDSP 307

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