Conserved Protein Domain Family
7tmA_MrgprX-like

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cd15106: 7tmA_MrgprX-like 
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors
The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.
Statistics
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PSSM-Id: 320234
View PSSM: cd15106
Aligned: 7 rows
Threshold Bit Score: 379.482
Threshold Setting Gi: 351696559
Created: 26-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #  ##               ######
gi 50401128   28 LSLTVLTCIVSLVGLTGNAVVLWLLGCRMRrnaFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTIS-----KILYPVM 102
gi 351696559  42 LIPDFLIIIIGLVGLPGNAVVIYLLGCRMRrntISVYILNLAASDFLVLCCHCFGSLLIVIRPFHHLYig-isFILINIA 120
gi 322510048  28 LSFTVLTCIISLVGLTGNAVVLWLLGYRMRrnaVSIYILNLAAADFLFLSFQIIRLPLRLINISHLIR-----KILVSVM 102
gi 311033400  28 LSFTGLTCIVSLVALTGNAVVLWLLGCRMRrnaVSIYILNLVAADFLFLSGHIICSPLRLINIRHPIS-----KILSPVM 102
gi 50401127   31 LIPVFLILFIALVGLVGNGFVLWLLGFRMRrnaFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISin-fpSFFTTVM 109
gi 440901983  43 MTLFVLTAIIALGGLAGNAVVLWLLGFHLHa--FTVYILNLAAADFLCLCCQVIDSLEALIACCSASSi---pSFFTSVM 117
gi 50401222   27 LTLSFLVPIITLLGLAGNTIVLWLLGFRMRrkaISVYVLNLSLADSFFLCCHFIDSLMRIMNFYGIYAhklskEILGNAA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                          # #####                      #  
gi 50401128  103 MFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRpTHLSAVVCVLLWALSLLRSILEWMLCgflfsgaDSAWCqtsDFITVA 182
gi 351696559 121 LIPYIAGLSTLSAISMERCLSVLWPIWYRCHRpRHTSAIVCTLLWALSLLLNILEWNYSgflyeffSSIWWknfDFIVTA 200
gi 322510048 103 TFPYFTGLSMLSAISTERCLSVLWPIWYRCRRpTHLSAVVCVLLWGLSLLFSMLEWRFCdflfsgaDSSWCetsDFIPVA 182
gi 311033400 103 TFPYFIGLSMLSAISTERCLSILWPIWYHCRRpRYLSSVMCVLLWALSLLRSILEWMFCdflfsgaNSVWCetsDFITIA 182
gi 50401127  110 TCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRpRHLSAVVCVLLWALSLLLSILEGKFCgflfsdgDSGWCqtfDFITAA 189
gi 440901983 118 TFAYLAGLSLLSAISTERCVSVLCPVWYRCHRpTHLSAIVCTVLWALALLLSILEGKYCgflltdfSHLWCqvfDFIAAG 197
gi 50401222  107 IIPYISGLSILSAISTERCLSVLWPIWYHCHRpRNMSAIICVLIWVLSFLMGILDWFFSgfl-getHHHLWknvDFIVTA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ### ### ##                                    #  ## ##  #          ## ###  #  ##
gi 50401128  183 WLIFLCVVLCGSSLVLLIRILCGSrkIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFlwihvdrevlFCHVHLVSIFLSA 262
gi 351696559 201 WLIFLFLTLSGSSLTLVVRILCGSrrMPVTRLYVTILFTVLVFLICALPFGLFWFLLlwlpitlpdfSCYFYIATTVLSC 280
gi 322510048 183 WLIFLCVVLCVSSLVLLVRILCGSrkMPLTRLYVTILLTVLVFLLCGLPFGILGALIyrmhlnlevlYCHVYLVCMSLSS 262
gi 311033400 183 WLVFLCVVLCGSSLVLLVRILCGSrkMPLTRLYVTILLTVLVFLLCGLPFGIQWALFsrihldwkvlFCHVHLVSIFLSA 262
gi 50401127  190 WLIFLFMVLCGSSLALLVRILCGSrgLPLTRLYLTILLTVLVFLLCGLPFGIQWFLIlwiwkdsdvlFCHIHPVSVVLSS 269
gi 440901983 198 WMMFLFGLLAGSSLALLLRILFKSqyIQLTRLYVTVGLTVLAFLLCGLPYGILWFLLiwiqddlfaiPCHNCLVVFGLSC 277
gi 50401222  186 FLIFLFMLLFGSSLALLVRILCGSrrKPLSRLYVTISLTVMVYLICGLPLGLYLFLLywfgihlhypFCHIYQVTVLLSC 265
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
Feature 1                                                 
gi 50401128  263 LNSSANPIIYFFVGSFRQRQNrq----nLKLVLQRALQDAS 299
gi 351696559 281 VNSCANPIIYFFIGSFRQQHQt------LKLVLQRALQDSY 315
gi 322510048 263 LNSSANPIIYFFVGSFRQRQNrq----nLKLVLQRALQDKP 299
gi 311033400 263 LNSSANPIIYFFVGSFRQRQNrq----nLKLVLQRALQDTP 299
gi 50401127  270 LNSSANPIIYFFVGSFRKQWRlqq--piLKLALQRALQDIA 308
gi 440901983 278 INSSINPIIYFFVGSFRQRQTkkrgrqtLKVVLQRALEDIS 318
gi 50401222  266 VNSSANPIIYFLVGSFRHRKKhr----sLKMVLKRALEETP 302

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