Conserved Protein Domain Family
7tmA_MrgprB

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cd15107: 7tmA_MrgprB 
mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors
The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.
Statistics
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PSSM-Id: 320235
View PSSM: cd15107
Aligned: 9 rows
Threshold Bit Score: 381.746
Threshold Setting Gi: 81912020
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #  ##              ###### 
gi 81912015   31 NTLNFLIVIISVVGMAGNATVLWLLGFHMHrnaFSVYVLNLAGADFLYLCAQTVYSLECV-LQFDNSYF---YFLLTILM 106
gi 81916289   28 QVMNLLSITISPVGMVLNIIVLWFLGFQICrnaFSAYILNLAVADFLFLCSHSIFSFLIV-CKLHYFLFyirQLLDTVTM 106
gi 81912019   31 RVMILLSIIIAFFGLAGNAMVLWLLAFRMRrnvFSVYILNLAGANFLFLCTHTAFSLEKIiVLFHSVHIhipLLFYTLST 110
gi 81916287   31 NTLNFLTVIIAMFGLAGNAIVLWLLAFHLPrnaFSVYVCNLACADFLQLCTQILGSLECF-LQLNRRHT---FFLTVVFM 106
gi 158564337  38 QAMILLSIIISLVGMGLNAIVLWFLGIRMHtnaFTVYILNLAMADFLYLCSQFVICLLIAfYIFYSIDInipLVLYVVPI 117
gi 341940973  43 CTMVFLSLIVALVGLVGNATVLWFLGFQMRrnaFSVYILNLAGADFLFICFQIGYCFHMI-LDIDSIPIeidLFYLVVLN 121
gi 81916288   30 NTLNFLTVIIAVVGLAGNGIVLWLLAFHLHrnaFSVYVLNLAGADFLYLFTQVVHSLECV-LQLDNNSF---YILLIVTM 105
gi 123797301  43 RTMTFLSLIIALVGLVGNATVLWFLGFQMSrnaFSVYILNLAGADFVFMCFQIVHCFYII-LDIYFIPTnffSSYTMVLN 121
gi 81912020   30 LAMSLLSIIIAIIGLTGNVIVLQLLGFHMHrnaFSVYIFNLSGANFLFLCTHIVFSLENLiRQFHYIDIhmaLFSVNVTI 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                          # #####                      #  #
gi 81912015  107 FNYLAGFCMIAAISTERCLSVTWPIWYHCQRpRHTSATVCALFWAFSLLLSLLLGQGCGflfskfDYSFCrycNFIATAF 186
gi 81916289  107 FAYVFGLSITTIISIECCLSIMWPIWYHCQRpRHTSAVICVLLWALSLLFPALQMEKCSvlfntfEYSWCgiiNIISGAW 186
gi 81912019  111 LAYLAGVSMVTAISAEYWLSGIWPYWYQGQRlKHTTTVICTGLWGLALLLSLLEGKSCGflgstyNQDVCwklDFIIVAW 190
gi 81916287  107 FAYLAGLCMIAAISVERSLSVMWPIWYHCQRpRHTSSIMCALLWAFCLLLNFLLGEGCGllfsdpKYYFCitcALITTAL 186
gi 158564337 118 FAYLSGLSILSTISIERCLSVIWPIWYRCKRpRHTSAITCFVLWVMSLLLGLLEGKACGllfnsfDSYWCetfDVITNIW 197
gi 341940973 122 FPYFCGLSILSAISIERCLSVMWPIWYHCQRpRHTSAVICTLLWVLSLVCSLLEGKECGflyytsDPGWCktfDLITATW 201
gi 81916288  106 FAYLAGLCMIAAISAERCLSVMWPIWYHCQRpRHTSAIMCALVWVSSLLLSLVVGLGCGflfsyyDYYFCitlNFITAAF 185
gi 123797301 122 IAYLSGLSILTVISTERFLSVMWPIWYRCQRpRHTSAVICTVLWVLSLVLSLLEGKECGflyytsGPGLCktfDLITTAW 201
gi 81912020  110 LAYLAGVSMITAISVEYWLSVLWPTWYHAQRpKHTSTVICTLLWVFSLLLTLWNWIICKvldyiyNWDMCwklALIIVVW 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ## ### ##                                    #  ## ##  #           ## ###  #  ##
gi 81912015  187 LIVIFMVLFVSSLALLAKIICGShrIPVTRFYVTIALTVLVFIFFGLPIGICVFLLpwih----mmlSSFFYEMVTLLSC 262
gi 81916289  187 LVVLFVVLCGFSLILLLRISCGSqqIPVTRLNVTIALRVLLLLIFGIPFGIFWIVDkwnee-nffvrACGFSHHILYVYC 265
gi 81912019  191 LLVLFAVLSRSIQVLLVRIFCGSqrTPVTKLHVTIVLTALVLVICGFPFGIIFYLLywttevyyimpCNSFHETILLLSY 270
gi 81916287  187 IILLTVVPSVSSLALLVKMICGShrIPVTRFYVTIALTLVVFIFLGLPFGIYSSFLimfke-fqsifSYHVLEVTIFLSC 265
gi 158564337 198 SVVFFGVLCGSSLTLLVRIFCGSqrIPMTRLYVTITLTVLVFLIFGLPFGIYWILYqwisn-fyyveICNFYLEILFLSC 276
gi 341940973 202 LIVLFVALLGSSLALVITIFWGLhkIPVTRLYVAIVFTVLVFLLFGLPYGIYWFLLvwiek-fyyvlPCSIYPVTVFLSC 280
gi 81916288  186 LIVLSVVLSVSSLALLVKIVWGShrIPVTRFFVTIALTVVVFIYFGMPFGICWFLLsrime-fdsifFNNVYEIIEFLSC 264
gi 123797301 202 LIVLFVVLLGSSLALVLTIFCGLhkVPVTRLYVTIVFTVLVFLIFGLPYGIYWFLLewire-fhdnkPCGFRNVTIFLSC 280
gi 81912020  190 LLVLFVVLSRSNQALLFRVFCGSqqTPVTRLLVTIMLTALVVLICGFGIGICFFYWkkeen--simpCGYFYETILLLSG 267
                        250       260       270
                 ....*....|....*....|....*....|....*...
Feature 1                                              
gi 81912015  263 VNSCANPIIYFFVGSIRHHRLqrqtLKLLLQRAMQDTP 300
gi 81916289  266 INICVNATIYFLVGSIRHGKFqkmtLKLILQRAIQGTP 303
gi 81912019  271 INSCANPIICLLVGSIRHCRFqcgtLRLLLHRAMQDIP 308
gi 81916287  266 VNSCANPIIYFLVGSIRQHRLqwqsLKLLLQRAMQDTP 303
gi 158564337 277 VNSCMNPIIYFLVGSIRHRRFrrktLKLLLQRAMQDTP 314
gi 341940973 281 VNSSAKPIIYCLVGSIRHHRFqrktLKLFLQRAMQDTP 318
gi 81916288  265 VNSCANPIIYFLVGSIRQHRLrwqsLKLLLQRAMQDTP 302
gi 123797301 281 INSCANPIIYFLVGSIRHHRFqrktLKLLLQRAMQDSP 318
gi 81912020  268 VNSCANPIICLFVGSIKHCQFqcgtLRLILQRAIQESP 305

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