Conserved Protein Domain Family
7tmA_MrgprD

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cd15108: 7tmA_MrgprD 
mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors
The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.
Statistics
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PSSM-Id: 320236
View PSSM: cd15108
Aligned: 7 rows
Threshold Bit Score: 363.306
Threshold Setting Gi: 432091027
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##               ####
gi 50401085   28 LVLSSLAMFTCLCGMAGNSMVIWLLGFRMHrn-pFCIYILNLAAADLLFLFSMASTLSLETQplvnt---tdkvhELMKR 103
gi 432091027  28 WVLSALTLLVCVCSLAGNGLVAWLLSCRVRrt-pCTVYVLHLALADLLFLLCMASVLSLEAAkahp------masEVLRR 100
gi 50401110   27 FSVTFLAMATCVGGMAGNSLVIWLLSCNGMqrspFCVYVLNLAVADFLFLFCMASMLSLETGpllivn-isakiyEGMRR 105
gi 281340622   7 EVLRSLATFTCVCGMIGNGLVVWLLSCRGQrt-pFCTYVLHLAIADFLFLLCTAVTLYLETPvl---------ayEVMER 76
gi 444510150  23 LAVSSLVMFTCVCGIAGNGVVIWLLSLRRErt-pFCVYVFNLAWADLLFLLCMASILCLEIIplshtwtrwdlayDVVRR 101
gi 119919404  26 WVLSAMVLFTCLGGFVGNGLVVWLLGSQGQrs-pFSVYILHLGVADLLFLLCMASKVILICFqlvnr---ihmalDIVSR 101
gi 440894225  27 EVLDALVVFTCVGGIVGNGLVVWLLGFQRRrg-pLGIYLLHLAVADLLFLLCSATLTVLSASswgihm--hrlgpRAVRS 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ## ##  #                                          # #####                      #
gi 50401085  104 LMYFAYTVGLSLLTAISTQRCLSVLFPIWFKCHRpRHLSAWVCGLLWTLCLLMNGLTSSFCskflkFNEDRCFRVDMVQA 183
gi 432091027 101 VKYFAYTVGLSMLTAISTLRCVSVVCPVWHRQHQsPRLSAWVCAALWTLSLVMNTLASVFCskywhSDENQCFVVDAVFS 180
gi 50401110  106 IKYFAYTAGLSLLTAISTQRCLSVLFPIWYKCHRpRHLSSVVSGALWALAFLMNFLASFFCvqfwhPNKHQCFKVDIVFN 185
gi 281340622  77 VRSFAYTASLSLLTAISTQRCLSVLFPIWYKCHRpQYLSAVVCALLWALSLLMSVVAALFCselwlGVESQCLTVDSVFS 156
gi 444510150 102 VKYFAYTASLSLLTAISVQRCISVLFPIWYKCHQpQHLSTVVCTLLWALSFLMNMLASFLCarflhSDLTQCFTVDMVLN 181
gi 119919404 102 MKYFTYTASLSLLTVISMQRCLSVLFPVWYKCHQpKHLSAVVCALLWVLSLLLNTVAMFLCsdflaRDELLCFRIDLVIS 181
gi 440894225 104 AGYLAYTVSLSLLTAASAQSCLPGLFPTWYRGCWhRRLSAAVCAVFWLLAVLLIVPAWYFHdeaehPHSWLGSKAETVLH 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ### ### ##                                       #  ## ##  #         ## ###  #
gi 50401085  184 ALIMGVLTPVMTLSSLTLFVWVRRSSqq-wrRQPTRLFVVVLASVLVFLICSLPLSIYWFVLYWlslppemQVLCFSLSR 262
gi 432091027 181 VLILGIFTPVMTVSSATLFVQVRRTSrrwrrRRPTRLYVVILASVLVFLVCALPLGLYWFLLFWlhlrpqvVRLYSCLSR 260
gi 50401110  186 SLILGIFMPVMILTSTILFIRVRKNSlm-qrRRPRRLYVVILTSILVFLTCSLPLGINWFLLYWvdvkrdvRLLYSCVSR 264
gi 281340622 157 FLVMGIFTPVMVLSSVTLFVRVRRSSrq-wgRRPTRLYVVVLASVVVFLVCALPLGISWYFLYWldlpqeqKTLFCYVAC 235
gi 444510150 182 GLIMGAFTPLMVLSSLILFVRVRKSSgq-wrRQPMRLYMVILASVFVFLIFSLPLGLYWFVLYWanlpnevTLLYTCVSR 260
gi 119919404 182 ILLMGVFTPLMAGSSLILCVGVQRSSta-thRRPTRVYVTVLVCILVFLAFALPLGICWFLISWldlpqktKTVFSLLAR 260
gi 440894225 184 FFTLVSFTPIMALSGMALCIQVQRSSpp-wqRPLTRLYVAVLLCVFVFLACALPLGISGFLLYWldlpqsaKTLFGHFTC 262
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
Feature 1          ##                                      
gi 50401085  263 LSSSVSSSANPVIYFLVGsRRSHRLptrsLGTVLQQALREEP 304
gi 432091027 261 LSATVSCGANPVIYFLVGsRHAGPRe--pLEAVLQRALQEAP 300
gi 50401110  265 FSSSLSSSANPVIYFLVGsQKSHRLqe-sLGAVLGRALRDEP 305
gi 281340622 236 LSSALSSSANPVIYFVVGsQGRRSLre-pLGAVLRRALREEP 276
gi 444510150 261 LSSAFSSSANPAIYFFVGsRRSQRLke-sLGTVLHRALQEEP 301
gi 119919404 261 LFSAISSSANPVIYFLVGrRKSRGLre-pLGAVLRRALREEP 301
gi 440894225 263 FSLSVSSSTKPMIYFLVGsGGRLSLre-pLGAVLSRVLQEEP 303

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