Conserved Protein Domain Family
7tmA_MrgprF

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cd15109: 7tmA_MrgprF 
mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors
The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.
Statistics
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PSSM-Id: 320237
View PSSM: cd15109
Aligned: 4 rows
Threshold Bit Score: 502.13
Threshold Setting Gi: 444510149
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #  ##              ###### 
gi 24638055   45 AVMNYIFLLLCLCGLVGNGLVLWFFGFSIKrnPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADyirSVCRVLGL 124
gi 24638048   45 AVTNYIFLLLCLCGLVGNGLVLWFFGFSIKrtPFSIYFLHLASADGMYLFSKAVIALLNMGTFLGSFPDyirRVSRIVGL 124
gi 109658320  45 AIMNYIFLLLCLCGLVGNGLVLWFFGFSIKrsPFSVYFLHLASADVGYLFSKAVFSILNTGGFLGPFADyvrAVSRIAGL 124
gi 444510149  29 AVMNYIFLLLCLCGLVGNGLVIWFFGFSIKrnPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADyvrSVSRILGL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                          # #####                       #  
gi 24638055  125 CMFLTGVSLLPAVSAERCASVIFPAWYWRRRpKRLSAVVCALLWVLSLLVTCLHNYFCvflgrgaPGAACRHmDIFLGIL 204
gi 24638048  125 CTFFTGVSLLPAISIERCVSVIFPTWYWRRRpKRLSAGVCALLWMLSFLVTSIHNYFCmflgheaPGTVCRNmDIALGIL 204
gi 109658320 125 CMVLTGVSLLPAISSERCLSVVFPTWYWRRRpKRLSAVVCSLLWALSLLVTCVHNYFCvflgrqaSGAGCTHmDAFLGIL 204
gi 444510149 109 FTFVTSVSLLPAISTERCVSVIFPAWYWRQRpKRLSAVVCALLWILSLLVTGIHNYFCvflgreaSRVACRHmDIFLGIL 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ### ### ##                                     #  ## ##  #      ## ###  #  ##   
gi 24638055  205 LFLLCCPLMVLPCLALILHVECRArrrQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFqipAPFPEYVTDLCICINS 284
gi 24638048  205 LFFLFCPLMVLPCLALILHVECRArrrQRSAKLNHVVLAIVSVFLVSSIYLGIDWFLFWVFqipAPFPEYVTDLCICINS 284
gi 109658320 205 LFLVFCPLMVLPCLALILHVECRArrrQRSAKLNHVILAVVSVFLVSSIYLGIDWFLFWVFripAPFPEYVTDLCLCINS 284
gi 444510149 189 LFLLFCPLMVLPCLALILHVECRArrrQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFqipAPFPEYVTDLCICINS 268
                        250       260       270
                 ....*....|....*....|....*....|....
Feature 1                                          
gi 24638055  285 SAKPIVYFLAGrDKSQRLwepLRVVFQRALRDGA 318
gi 24638048  285 SAKPIVYFLAGrDKSQRLwepLRVVFQRALRDGA 318
gi 109658320 285 CAKPVVYFLAGrDKSQRLwepLRVVFQRALRDGA 318
gi 444510149 269 SAKPVVYFLAGrDKSQRLwepLRVVFQRALRDGA 302

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