Conserved Protein Domain Family
7tmA_MrgprH

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cd15110: 7tmA_MrgprH 
mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.
Statistics
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PSSM-Id: 320238
View PSSM: cd15110
Aligned: 6 rows
Threshold Bit Score: 343.999
Threshold Setting Gi: 483501346
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #  ##                   ##
gi 81916654   35 HTYFLVSLVICSLGLAGNGLLIWFLIFCIKrkpFTIYILHLAIADFMVLLCSSIMKLVNTfhiyn--------mtleSYA 106
gi 118088328  33 LTPLWVIMIISFLGFCENGIVLWCLCFQIKrnpFTAYITHLSIADISLLFCIFILSIEYIagfgfay---gfyyyitTTL 109
gi 126311256  23 MILAFVSLFITLLGTAGNGFVIWFLLFHFKknpFTVYILHLSIADLTFLLCAFTTIIGIIisynfstg-pfkievflIIF 101
gi 135920     33 PIVHWVIMSISPVGFVENGILLWFLCFRMRrnpFTVYITHLSIADISLLFCIFILSIDYAldyelss----ghyytiVTL 108
gi 483501346   8 LSEVPATLLICLCGLVGNGAVLWLLGCRIRrnpITVYVFSLAIADFTFLLSIAIALVMFYgplsfchrlgsrdvmamLNI 87
gi 50794283   37 KFMESFCLISAACGMVGNGIVLWYLGFCIRrnhFTVYILNLAAADFGYLLCIAIETVQYLmqfnv--------gvqfGIF 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #### ##  #                                          # #####                     
gi 81916654  107 ILFMIFGYNTGLHLLTAISVERCLSVLYPIWYQCQRpKHQSAVACMLLWALSVLVSGLENFFCile----vkpQFPECry 182
gi 118088328 110 SIVFLLGYNTGLYLLTAISIERCLSIVYPIWYRCHRsQHQSAIVCAILWTLSFLMTIAEYLTCkddstkeqfdDANHCqa 189
gi 126311256 102 YVLVLFGYNTGFYLLTAISVERCLSVLYPIWYQCQRsKYQSAIVCTILWVFSVFMTSLEAFMYvwei---gfsVRIYIvl 178
gi 135920    109 SVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRpKYQSALVCALLWALSCLVTTMEYVMCidre--eeshSRNDCra 186
gi 483501346  88 IIIFVFTTSIYLLAAFAISVDRCVSVFFPIWYRCYRpRHLSGIVSGLLWAFAGAFVSSMYLSFhf-------rVTYEEv- 159
gi 50794283  109 LFLDLFTYGTGLYLLTAISIERCLSVLCPIWCRSHRpKHLSAIISGLLWCLSLLLNTVGYILCsi-------hPSGSCrm 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  ### ### ##                                    #  ## ##  #         ## ###
gi 81916654  183 vyIFSCILTFLVFVPLMIFSNLILFIQVCCNLkpRQPTKLYVIIMTTVILFLVFAMPMKVLLIIGyyssslddsVWDSLP 262
gi 118088328 190 mlIFIWILTFLIFIPLMILSSLILVIRIHRNSlrPHSSKLYIIIVATVVVFLIFAMPMRLLYLLNyhhw--sslLSQQNH 267
gi 126311256 179 -qIVVLILNFLVFAPLMVISSLTLFIKVFCNLkhRQPAKLYIIIITTVILFLLFAMPCRFSLMMSnlkainhesVRVLFP 257
gi 135920    187 viIFIAILSFLVFTPLMLVSSTILVVKIRKNTwaSHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYyey---wstFGNLHH 263
gi 483501346 160 -fGGIGIAIIVTLSSVMLISNLSLFIKLRCGFqrRHPGKLYVAVLLNVIFFFVLAIPFSIEVFLNlnh----rwHLFPNQ 234
gi 50794283  182 llITIGVLDFLVCTPLMLFFSLTLFLRVKCSSqkFRTGRLFTVIMLTVLFFLIFAVPLSVLILFDflg----ykFLYSPE 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
Feature 1          #  ##                                     
gi 81916654  263 YLNMLSTINCSINPIVYFVVGsLRRKRSrksLKEALQKVFEEKP 306
gi 118088328 268 VTIVLSTVNSSINPLVYFFVGsSKNKRFkesLKVVLSRALADGL 311
gi 126311256 258 YFTLLSFVNSSVNPIVYVVVGrLRGQRTrksLKDTLQKVFEDKS 301
gi 135920    264 ISLLFSTINSSANPFIYFFVGsSKKKRFkesLKVVLTRAFKDEM 307
gi 483501346 235 VPFLLALLNSNTNPIVYFLVGsCQRGRIqgsLKAAFRQVFEEKA 278
gi 50794283  258 IGFVLSCVNSSLNPVIYFLVGsYRDRRIkftLRLAFQRVFEDSA 301

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