Conserved Protein Domain Family
7tmA_MrgprE

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cd15112: 7tmA_MrgprE 
mas-related G protein-coupled receptor subtype E, member of the class A family of seven-transmembrane G protein-coupled receptors
The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.
Statistics
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PSSM-Id: 320240
View PSSM: cd15112
Aligned: 3 rows
Threshold Bit Score: 383.414
Threshold Setting Gi: 115502418
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #  ##              ###### 
gi 115502418  24 LIILSLTEGLGLGGLLGNGAVLWLLSSNVYrnpFAIYLLDVACADLIFLGCHMVAIVPDLlQGRLDFPgfvqTSLATLRF 103
gi 126333706  45 IFILALTELAGLGGLAGNGLVLWLLSSHIHrnnFSIYLLDLASADFLFLCCHLVIAIPETlQNHFSFPhyvyDSLLALRF 124
gi 30425312   21 LTILSLTELLSLGGLLGNGVALWLLNQNVYrnpFSIYLLDVACADLIFLCCHMVAIIPELlQDQLNFPefvhISLTMLRF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                          # #####                      #  #
gi 115502418 104 FCYIVGLSLLAAVSVEQCLAALFPAWYSCRRpRHLTTCVCALTWALCLLLHLLLSGACtqffgepSRHLCrtlWLVAAVL 183
gi 126333706 125 FFFTVGLSLLGAISAEQCAATLWPGCYQRRRpPHTSAVVCALLWALCLLLHFLSYGTCgelsggdAGTLCgriGLARVAL 204
gi 30425312  101 FCYIVGLSLLAAISTEQCLATLFPAWYLCRRpRYLTTCVCALIWVLCLLLDLLLSGACtqffgapSYHLCdmlWLVVAVL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ## ### ##                                    #  ## ##  #      ## ###  #  ##     
gi 115502418 184 LALLCCTMCGASLMLLLRVERGPqrPPPRGFPGLILLTVLLFLFCGLPFGIYWLSRNllwyiPHYFYHFSFLMAAVHCAA 263
gi 126333706 205 LLLLLALMCVSGLVLLVRMECGSprQRPHKFYAIVLFTVLTFLFCGLPFGIYRLSLNwl-riPHYYYYLSVLMAAVNSSA 283
gi 30425312  181 LAALCCTMCVTSLLLLLRVERGPerHQPRGFPTLVLLAVLLFLFCGLPFGIFWLSKNlswhiPLYFYHFSFFMASVHSAA 260
                        250       260       270
                 ....*....|....*....|....*....|..
Feature 1                                        
gi 115502418 264 KPVVYFCLGsAQGRRLP--LRLVLQRALGDEA 293
gi 126333706 284 KPPIYFCVGsLRRGRFRepFKTVLLRALGDEA 315
gi 30425312  261 KPAIYFFLGsTPGQRFRepLRLVLQRALGDEA 292

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