Conserved Protein Domain Family
7tmA_PD2R2_CRTH2

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cd15118: 7tmA_PD2R2_CRTH2 
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.
Statistics
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PSSM-Id: 320246
View PSSM: cd15118
Aligned: 4 rows
Threshold Bit Score: 446.941
Threshold Setting Gi: 542234237
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##            ###### #
gi 296439334  33 HAAVLLHGLASLLGLVENGVILFVVGCRMR-QTVVTTWVLHLALSDLLASASLPFFTYFLavGHSWELGttfCKLHSSIF 111
gi 47218448   18 VGLICIHGLVSGLGILENALTLWVVGFRLRrRTVASVWVLNLALSDLLATLTLPLFTFYLksSNSWELGnplCKIQSSIF 97
gi 557027074  29 YASVCIHGIVSVFGVAENVIIIWIIGYKLR-RTVITMWIFNLALSDLMVTLSLPFFTYFLasGHTWNLGnifCRIHSSIF 107
gi 542234237  21 VFTITLHGIFATIGIVENLLIVAVVGFHVR-RSIISIWILNLAVSDLLATSCLPFFTLYMarGKTWTLGttfCRIHSSIF 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 296439334 112 FLNMFASGFLLSAISLDRCLQVVRPVWAQNHRtVAAAHKVCLVLWALAVLNTVPYFVFRdtisrlDGRIMCYYNVlllnp 191
gi 47218448   98 FLNMFVSAFLLAAISLDRCLLISKPVWSQNHRsVAAAWRLCGLGWLWAAVNTFPYFFFRsvtekyDGKKLCYHNFalyss 177
gi 557027074 108 FLNMFVSGFLLSAISIDRCLLVVVPIWAQNHRnVKTASYICIGIWVISIINTMPYFVFRstierqDGRIMCYYNFlqfsp 187
gi 542234237 100 FLNMFVSGFLLAAISLDRCLVVLKPVWAQNHRnIRLVKKICGVIWAMALICTIPFFLFRdviplkDGRKLCYYDYarflp 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #  ### ### ##                                             #  ## #
gi 296439334 192 gpd----rdatcnsrQVALAVSKFLLAFLVPLAIIASSHAAVSLrl--qHRGRRRPGRFVRLVAAVVAAFALCWGPYHVF 265
gi 47218448  178 sras---lhthcklwQAGTAISKLLLAFLIPLVIIAVSYIQISLvlktrHKRRRKNSSFTKMVTLVVAVFAVCWAPYHIF 254
gi 557027074 188 skd----ihdlcgfrQYAFAASKLVIAFLVPLVIITISYIGVSLki--rQRHRKRSGRFFKLMVTVIVTFIVCWSPYHIF 261
gi 542234237 180 epknqtnnipiikqrKEGLAIMKLFFAFLIPLVIIIVSYAVVHSii--aNRCNRRPFRFVRLVVSVVVSFVLCWAPYHIF 257
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #            ## ###  #  ##                     
gi 296439334 266 SLLEarahanpglrpLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKL 315
gi 47218448  255 CIIEvaadsqhrsfrLVESGLQIATTAAFLNPVLNPILYVFSCPNFCMRI 304
gi 557027074 262 SILEaeshyqthlrpLVGKGLPFVTSLAFINSIINPCLYVFTCPDFMTKI 311
gi 542234237 258 IVIEvmapnshsvqgFIIQALPVAATIGFLNSVLNPVLYVFSCPDLCNKI 307

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