Conserved Protein Domain Family
7tmA_GPR1
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cd15119: 7tmA_GPR1 
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.
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Statistics
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PSSM-Id: 320247
Aligned: 6 rows
Threshold Bit Score: 394.11
Created: 15-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                              #  ##            ###### ##
P46091        39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAmnFHWPFGiWLCKANSFTAQ 118 human
XP_421955     31 MISLSFYSVAFLLGVPGNAIVIWFMGFKWDKSVSTLWFLNLAIADFIFVLFLPLYITYVAmgFHWPFGkWLCKMNSFIAL 110 chicken
XP_004917808  35 IVSIVIYSLAFILGVPGNAMVIWFTGFKWEKTVSTLWFLNLAIADLIFVLFLPLHITYVAtdFHWPFGkYFCKINSFIAV 114 western clawed ...
XP_005998460  37 MVSMIIYIIACVLGVPGNAIVIWVTGFKMKKTVNVLWLLHLGVADFVFVVFLPFSIIYLAldFHWPFGvWMCKINSFVTV 116 coelacanth
XP_007900499  51 IFSIVIYIIAFLLGVPGNALVIWVTGFNLKKTVTTQWFLNLAIADLVFVLFLPLSVAYIAleYHWPFGiMLCKINSFVAI 130 elephant shark
XP_003961941  37 ILSVVIYIVSFVLGLVGNGTVIWVTAFKSKKTINSVWLLNLAIADFVFLLFLPLHIDYILrdFHWKFGvAMCKINSFVSV 116 torafugu

Feature 1          #                                            # #####                          
P46091       119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTvefn---nhtLCYNNFqkhd 195 human
XP_421955    111 LNMFASVFFLTFISLDRYIRLVHPVFSYKYRTIKNTLILSVIIWMSAAVIGGPALYFRDTatal--nnvtICYNNFhvhd 188 chicken
XP_004917808 115 LNMFASVFFLTVIGLDRYLFLAHTRFVQRHRTLCKSMILSGIVWISAGIIAAPALYYRDTteir--ksvtICFNNFhdyd 192 western clawed ...
XP_005998460 117 LNMFGSTLFLTVISLDRYLSTAYPHWSNKFRTLKSACIVCLVVWLSAVALSLPYLYFRDTmvla--sgktVCYQNFhnhs 194 coelacanth
XP_007900499 131 LNMHSSILFLTVISVDRCICFAHPTWAYRIRSHSSATFLCLLVWAVSLVLSSPYLYFRDTvsfsfkinttVCFSNYmkgs 210 elephant shark
XP_003961941 117 LNMYASVLFLTVLSIDRYVSLVHLGWSHRYRTRGRAWIACGCIWSVAAAISCPALIFRDTmrls---drvICFNNFltqd 193 torafugu

Feature 1                 #  ### ### ##                                            #  ## ##  #   
P46091       196 p--dltliRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKkr-sILISSRHFWTILVVVVAFVVCWTPYHLFSIWELti 272 human
XP_421955    189 r--elillRHHILIWVRLAFGYLFPLLTMVICYSLLIVKVKrr-tVLTSSRLFWTIVAVVVAFFLCWTPYHIFSIVELsa 265 chicken
XP_004917808 193 h--svikrTHTFLTLIRFFIGYLFPLLTMICSYSLLAIRIKtk-nALGSSKFFWTVFTIVVAFFVCWTPYHIFSLLELnv 269 western clawed ...
XP_005998460 195 k--ylivmRHNILVWVRFINGFLLPSLTMVVCYSLLAFQVKrt-tLQDLSKFSRIIAALIIAFFICWTPLHVFSILELaa 271 coelacanth
XP_007900499 211 qdhdtavaRHTTQVLLRFFFGFLFPFITMVVCYSLLLVNMKri-rLVISNKLFPITIAVIIVFFVCWTPYHILSILEVvq 289 elephant shark
XP_003961941 194 g--hiaamRHIIIVVLRTVVGFLLPFTAICVTGILLTIKEKqsrgLVRMSSFSRMVSAVILAFFLCWAPFHVFGLMELsi 271 torafugu

Feature 1                   ## ###  #  ##                     
P46091       273 hhns--yshhvMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315 human
XP_421955    266 hhde--nlhdlLQDGIPLSTGLAFINSCLNPILYVLISKKFQAQV 308 chicken
XP_004917808 270 hhss--efrewNRIGMPISTSVAFINSCLNPIIYVLISKAFMVHL 312 western clawed frog
XP_005998460 272 hhns--hlhqvLHNGMPFASSLAFINSCLNPILYLFIGKNFKLHL 314 coelacanth
XP_007900499 290 hssrsfhyfyvIRHGIPIASSLAFLNSCLNPILYIFIGHNVKTLL 334 elephant shark
XP_003961941 272 hssl--ylhntLKAGFPLATSLGFFNSCINPLLYILLGKKVRHIL 314 torafugu

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