Conserved Protein Domain Family
7tmA_GPR1

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cd15119: 7tmA_GPR1 
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.
Statistics
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PSSM-Id: 320247
View PSSM: cd15119
Aligned: 6 rows
Threshold Bit Score: 394.11
Threshold Setting Gi: 632968389
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #  ##            ###### ##
gi 82654939   39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAmnFHWPFGiWLCKANSFTAQ 118
gi 50750316   31 MISLSFYSVAFLLGVPGNAIVIWFMGFKWDKSVSTLWFLNLAIADFIFVLFLPLYITYVAmgFHWPFGkWLCKMNSFIAL 110
gi 512866404  35 IVSIVIYSLAFILGVPGNAMVIWFTGFKWEKTVSTLWFLNLAIADLIFVLFLPLHITYVAtdFHWPFGkYFCKINSFIAV 114
gi 556985474  37 MVSMIIYIIACVLGVPGNAIVIWVTGFKMKKTVNVLWLLHLGVADFVFVVFLPFSIIYLAldFHWPFGvWMCKINSFVTV 116
gi 632968389  51 IFSIVIYIIAFLLGVPGNALVIWVTGFNLKKTVTTQWFLNLAIADLVFVLFLPLSVAYIAleYHWPFGiMLCKINSFVAI 130
gi 410896908  37 ILSVVIYIVSFVLGLVGNGTVIWVTAFKSKKTINSVWLLNLAIADFVFLLFLPLHIDYILrdFHWKFGvAMCKINSFVSV 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                            # #####                          
gi 82654939  119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTvefn---nhtLCYNNFqkhd 195
gi 50750316  111 LNMFASVFFLTFISLDRYIRLVHPVFSYKYRTIKNTLILSVIIWMSAAVIGGPALYFRDTatal--nnvtICYNNFhvhd 188
gi 512866404 115 LNMFASVFFLTVIGLDRYLFLAHTRFVQRHRTLCKSMILSGIVWISAGIIAAPALYYRDTteir--ksvtICFNNFhdyd 192
gi 556985474 117 LNMFGSTLFLTVISLDRYLSTAYPHWSNKFRTLKSACIVCLVVWLSAVALSLPYLYFRDTmvla--sgktVCYQNFhnhs 194
gi 632968389 131 LNMHSSILFLTVISVDRCICFAHPTWAYRIRSHSSATFLCLLVWAVSLVLSSPYLYFRDTvsfsfkinttVCFSNYmkgs 210
gi 410896908 117 LNMYASVLFLTVLSIDRYVSLVHLGWSHRYRTRGRAWIACGCIWSVAAAISCPALIFRDTmrls---drvICFNNFltqd 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #  ### ### ##                                            #  ## ##  #   
gi 82654939  196 p--dltliRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKkr-sILISSRHFWTILVVVVAFVVCWTPYHLFSIWELti 272
gi 50750316  189 r--elillRHHILIWVRLAFGYLFPLLTMVICYSLLIVKVKrr-tVLTSSRLFWTIVAVVVAFFLCWTPYHIFSIVELsa 265
gi 512866404 193 h--svikrTHTFLTLIRFFIGYLFPLLTMICSYSLLAIRIKtk-nALGSSKFFWTVFTIVVAFFVCWTPYHIFSLLELnv 269
gi 556985474 195 k--ylivmRHNILVWVRFINGFLLPSLTMVVCYSLLAFQVKrt-tLQDLSKFSRIIAALIIAFFICWTPLHVFSILELaa 271
gi 632968389 211 qdhdtavaRHTTQVLLRFFFGFLFPFITMVVCYSLLLVNMKri-rLVISNKLFPITIAVIIVFFVCWTPYHILSILEVvq 289
gi 410896908 194 g--hiaamRHIIIVVLRTVVGFLLPFTAICVTGILLTIKEKqsrgLVRMSSFSRMVSAVILAFFLCWAPFHVFGLMELsi 271
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
Feature 1                   ## ###  #  ##                     
gi 82654939  273 hhns--yshhvMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
gi 50750316  266 hhde--nlhdlLQDGIPLSTGLAFINSCLNPILYVLISKKFQAQV 308
gi 512866404 270 hhss--efrewNRIGMPISTSVAFINSCLNPIIYVLISKAFMVHL 312
gi 556985474 272 hhns--hlhqvLHNGMPFASSLAFINSCLNPILYLFIGKNFKLHL 314
gi 632968389 290 hssrsfhyfyvIRHGIPIASSLAFLNSCLNPILYIFIGHNVKTLL 334
gi 410896908 272 hssl--ylhntLKAGFPLATSLGFFNSCINPLLYILLGKKVRHIL 314

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