Conserved Protein Domain Family
7tmA_LTB4R1

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cd15121: 7tmA_LTB4R1 
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors
Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.
Statistics
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PSSM-Id: 320249
View PSSM: cd15121
Aligned: 4 rows
Threshold Bit Score: 371.842
Threshold Setting Gi: 3041713
Created: 26-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##            ###### #
gi 3041713    19 LLAIILLSVALAVGLPGNSFVVWSILKRMQKRsVTALMVLNLALADLAVLLTAPFFLHFLaq-gtWSFGlagCRLCHYVC 97
gi 465956194  22 KLGLTVLSLAFILGFPGNIFVVWSALWRVQKRtVTCLLILHLALADCAVLLTSPFFLRLLsa-gkWEFGpvvCQLCHYVC 100
gi 47215464   26 QVGIAILTLAFILGFPGNLFVVWSVLCRVKKRsVTCILVLNLALADAFLLLSAPLFLRYLsggrgWEFGsvaCKAVHYLS 105
gi 512812771  34 RLGIAILSLAFIIGFPGNAFIIWTVLTRMKKRtVTCILILHLAIADMVVILTAPFFLHFLdn-gnWVFGenvCKLCHYIG 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 3041713    98 GVSMYASVLLITAMSLDRSLAVARPfvSQKLRtKAMARRVLAGIWVLSFLLATPVLAYRtvvpw----ktnmSLCFPryp 173
gi 465956194 101 GVSMYASIFLITLMSLDRCLAVTKPfiSQKIRtALVVRSLVLAIWMVSFLLALPVIFYRklvh-----rgrhLLCDLshp 175
gi 47215464  106 SVNMYVSIFLICLMSMDRCLAATKPflSQRMRtKRSLHALLMAVWIIAFLLSLPMPFYRsnlkktlpnnitlKFCIPyhw 185
gi 512812771 113 CLSMYASIWLISFMSMDRFLAVAKPftSQIMRtKTAVRGIVLAIWLVAFLCSIPMPFYRtvlt-----frnmTICMPlhk 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  ### ### ##                                           #  ## ##  #        
gi 3041713   174 -seGHRAFHLIFEAVTGFLLPFLAVVASYSDigrrlqarRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEagralagq 252
gi 465956194 176 -atGHLVFHNLFETLTGFVLPFTAIIWSYCVigrrlqetRFRRKRRTNRLIVLIVAAFALFWLPFHVVNILDvagalsh- 253
gi 47215464  186 nsvGHEAFQYLFETIMGFLLPFTLINTCYSTvlcrlrsaRFKRRSRGSWLILMIICAFAVFWLPYHIVNLIQvagllqn- 264
gi 512812771 188 -spGHIVFQYLFETMIGFLIPFSIIVFCYLYiclrlrtaKFQSKHKTNRLVTLIVATFCLFWLPYHVVNIIQvtgaltsg 266
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
Feature 1                  ## ###  #  ##                      
gi 3041713   253 aaglglvgkrLSLARNVLIALAFLSSSVNPVLYACAGGglLRSAG 297
gi 465956194 254 ---skglimaGKLARPTLTALAFFSSSVNPILYTFTGGalIKSAG 295
gi 47215464  265 ---nasvlkaAKTARPNVTAFAYFSSAVNPILYVFAGSshIRQAG 306
gi 512812771 267 p-tglklmkaAQKARPNVTALVFLSSSVNPVLYAYAGGsfIRTAG 310

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