Conserved Protein Domain Family
7tmA_LTB4R2

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cd15122: 7tmA_LTB4R2 
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors
Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.
Statistics
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PSSM-Id: 320250
View PSSM: cd15122
Aligned: 4 rows
Threshold Bit Score: 354.11
Threshold Setting Gi: 23821812
Created: 26-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##           ###### 
gi 465956193 240 VTGIVFLLLAALIGLPGNLFVVWSILWKMKpscrsvTCLLVLNLAMADGAVLLLTPFFILFLtfktWFFGlavCKGVYYL 319
gi 23821812   52 ATGTAFLLLAALLGLPGNGFVVWSLAGWRPargrplAATLVLHLALADGAVLLLTPLFVAFLtrqaWPLGqagCKAVYYV 131
gi 512817971  21 ISGTIFLALAASLGLPGNAFIIWSILWKMKgreksvTCILILNLAVADGTVLLLSPFFITFLvlktWIFGravCKLAYYL 100
gi 557008567  34 AIGSIILTLALFIGLPGNCFIIWSILCKLRkr--svTSILILNLAVADGVVLMLTPFFITFLamrgWVFGeviCKMVYYI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                            # #####                        
gi 465956193 320 CCVNMYASIFIITLMSVDRCLAVSRPylSQAIRkKHLVVKILAALWAAAVLLAVPAFVYRqlvsdl--sgrwlICEPCHa 397
gi 23821812  132 CALSMYASVLLTGLLSLQRCLAVTRPflAPRLRsPALARRLLLAVWLAALLLAVPAAVYRhlw-------rdrVCQLCHp 204
gi 512817971 101 CCLNMYASIFIIALMSLDRFLAVFRPymAQSLRkKDMVTKILIAIWLLAGALALPAFAYReviesq--klnakICEPCHa 178
gi 557008567 112 CCFSMYTSIMIIMLMGVDRYVAVAKPyvAQSIRkKKLVRKILFGIWFLSFLLALPPLFYRkvqkdevegmnmsICRNFHk 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #  ### ### ##                                              #  ## ##  #      
gi 465956193 398 trglAVFHFTMETVVAFVVPFAVIVGCYSAILVRLRgrr--whRRGARTGKLIAAVVLCFAALWVPYHVVNVLQvasnva 475
gi 23821812  205 spvhAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRgarwgsgRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQavaala 284
gi 512817971 179 srgeSIFHYTFETLVAFLLPFPMVLFSYILVLVKLKas---rfGQRSRIEKLIAAILVTFAILWLPYHVVNAIQvtsnlt 255
gi 557008567 192 sdghKIFHYTFETVLSFIIPLIVITFSYSNIARRLKnt---rfRRRVRMEKIIIIIMVAFALLWVPYHIVNILEvfacla 268
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                    ## ###  #  ##                      
gi 465956193 476 sgr-vaeslghaWKAGRAGATALAFLSSSINPVLYVFAAgDLIKTSG 521
gi 23821812  285 ppegalaklggaGQAARAGTTALAFFSSSVNPVLYVFTAgDLLPRAG 331
gi 512817971 256 tgk-vsenlkkaAKISRAGATALAFFSACVNPLLYAFAAsDLFRIFG 301
gi 557008567 269 eed-lknklndiAKSLRAAVTALAFVSSGINPLLYTFAGtGFIKTSG 314

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