Conserved Protein Domain Family
7tmA_BRS-3

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cd15123: 7tmA_BRS-3 
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors
BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.
Statistics
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PSSM-Id: 320251
View PSSM: cd15123
Aligned: 4 rows
Threshold Bit Score: 549.909
Threshold Setting Gi: 416726
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 416726     48 CAIYITYAVIISVGILGNAILIKVFFKTKSMQTvPNIFITSLAFGDLLLLLTCVPVDATHYlaegWLFGRiGCKVLSFIR 127
gi 1705504    47 ALISVTYAVIISVGILGNTILIKVFFKIKSMQTvPNIFITSLAFGDLLLLLTCVPVDASRYivdtWMFGRaGCKIISFIQ 126
gi 45383350   47 CTIYVTYAVIISVGLLGNAILIKVFFKIKSMQTvPNIFITSLAFGDLLLLLTCVPVDATRYivdtWIFGRiGCKLLSFIQ 126
gi 556959472  43 CIISVTYAIIIAVGILGNSILIKVFFTIKSMQTvPNIFITSLAMGDLMLLLTCVPVDATRYiadsWLFGKiGCKLISFIQ 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 416726    128 LTSVGVSVFTLTILSADRYKAVVKPleRQPSNaILKTCVKAGCVWIVSMIFALPEAIFSnvytfrdpnknmTFESCTSYP 207
gi 1705504   127 LTSVGVSVFTLTVLSADRYRAIVKPlqLQTSDaVLKTCGKAVCVWIISMLLAAPEAVFSdlyefgssekntTFEACAPYP 206
gi 45383350  127 LTSVGVSVFTLTVLSADRYRAIVKPleLQTSDaLLKTCCKAGCVWIVSMVFAIPEAVFSdlysfsnpeknvTFEACAPYP 206
gi 556959472 123 LTSVGVSVFTLTVLSADRYRAIVKPmeLKTSDaVLRTCCKAGCIWIISMLLAIPEAVFSdlysftdpdkntTFEACAPYP 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #  ### ### ##                                                         #  #
gi 416726    208 vskkllQEIHSLLCFLVFYIIPLSIISVYYSLIARtlykstlnipteeqsharKQIESRKRIARTVLVLVALFALCWLPN 287
gi 1705504   207 vsekilQETHSLICFLVFYIVPLSIISAYYFLIAKtlykstfnmpaeehtharKQIESRKRVAKTVLVLVALFAVCWLPN 286
gi 45383350  207 vsekilQEVHSLVCFLVFYIVPLAVISVYYFLIARtlykstfnmpaeehgharKQIESRKRVAKTVLVLVALFAFCWLPN 286
gi 556959472 203 vsekilQEIHSLMCFLVFYIIPLSVISVYYFLIAKtlfrsaynmpseehahvhKQIETRKRLAKTVLVFVGLFAFCWMPN 282
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
Feature 1        # ##  #             ## ###  #  ##                     
gi 416726    288 HLLYLYHSFTsqtyvdpsamHFIFTIFSRVLAFSNSCVNPFALYWLSKsFQKHF 341
gi 1705504   287 HMLYLYRSFTyhsavnssafHLSATIFARVLAFSNSCVNPFALYWLSRsFRQHF 340
gi 45383350  287 HILYLYRSFTyhtsvdastfHLIVTIFSRALAFSNSCVNPFALYWLSKsFRQHF 340
gi 556959472 283 HILYLYRSFTyhssvdssmfHLVATIFSRALAFSNSCVNPFALCWLSKaFRQQF 336

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