Conserved Protein Domain Family
7tmA_GRPR

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cd15124: 7tmA_GRPR 
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.
Statistics
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PSSM-Id: 320252
View PSSM: cd15124
Aligned: 5 rows
Threshold Bit Score: 516.375
Threshold Setting Gi: 45383344
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 232185     41 YVIPAVYGVIILIGLIGNITLIKIFCTVKSmrNVPNLFISSLALGDLLLLITCAPVDASRYLadrWLFGriGCKLIPFIQ 120
gi 47230631    6 VAIASVYSVIIALGLIGNITLIKTFCSPKCtrNVPNLFMSSLALGDVLLLVTCAPVDASRYLteeWLFGrvGCKIIPFIQ 85
gi 45383344   43 YAIPTIYGIIILIGLIGNITLIKIFCTVKSmrNVPNLFISSLALGDLLLLVTCVPVDASRYLadeWLFGriGCKLIPFIQ 122
gi 301617736  40 YAIVPVYGIIILIGLIGNITLIKIFCTVKSmrNVPNLFISSLALGDLLLLVTCAPVDASRFLadkWLFGrvGCKLIPFIQ 119
gi 556986642  44 YAIPTVYGIITLIGLIGNITLIKIFCTVKSmrNVPNLFISSLALGDLLLLLTCAPVDASRYLaddWLFGrvGCKLIPFIQ 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 232185    121 LTSVGVSVFTLTALSADRYKAIVRPmDIQASHaLMKICLKAAFIWIISMLLAIPEAVFsdlhpfheesTNQTFISCAPYP 200
gi 47230631   86 LTSVGVSVFTLTALSADRYRAIVKPlDVQTPStTATILLRAALIWVLSLILAIPEAVFsdlhtfnitsTNESFVTCAPYP 165
gi 45383344  123 LTSVGVSVFTLTALSADRYKAIVRPmEIQASHaLMKICVRAAIIWIASMLLAIPEAVFsdlhpfhdkgTNKTFISCAPYP 202
gi 301617736 120 LTSVGVSVFTLTALAADRYTAIVRPmDIQANNaLTKICIKAALIWILSMTLAIPEAVFsdmhpfydkeINVTFVSCAPYP 199
gi 556986642 124 LTSVGVSVFTLTALSADRYKAIVRPmDIETSNaLMKICIKAALIWIFSMMLAIPEAVFsdlhpfydkgTNKTFVSCAPYP 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #  ### ### ##                                                         #  #
gi 232185    201 HsnelHPKIHSMASFLVFYVIPLSIISVYYYFIaknliqsaynlpvegnihvkkqiESRKRLAKTVLVFVGLFAFCWLPN 280
gi 47230631  166 HagelHPRFHSMASFLIFYVIPLSVITVYYTFIaqslmtsalnlptegnthsqqqvKSRKRLAKTVLVFVGLFAICWFPS 245
gi 45383344  203 HsdglHPKIHSMASFLIFYIIPLSVISVYYYFIaknlirsaynipvegnvhvrkqiESRKRLARTVLVFVCLFAFCWLPT 282
gi 301617736 200 HsnglHPRIHSTTSFLIFYVIPLSIISVYYYFIaknlmrsasnmpvegnvhvrrqiESRKRLAKTVLVFVGLFAFCWLPI 279
gi 556986642 204 HsddlHPKIHSMASFMIFYIIPLSIISLYYYFIaenlirsaynmpvegnvhvkrqiESRKRLAKTVLVFVGLFALCWLPN 283
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1        # ##  #            ## ###  #  ##                     
gi 232185    281 HVIYLYRSYHysevdtsmlHFVTSICARLLAFTNSCVNPFALYLLSkSFRKQF 333
gi 47230631  246 HVVYLYRSYHysevdtsmaHFVSSIIARILAFTNSCLNPFALYLMSkSFKKQF 298
gi 45383344  283 HIIYLYRSYHysevdtsvlHFIASICARILAFTNSCVNPFALYLLSkSFRKQF 335
gi 301617736 280 HIIYLYRSYHysevdtsvlHYISSICARVLAFTNSCVNPFALYLLSkSFRKQF 332
gi 556986642 284 HIIYLYRSYHysevdtsmlHFVTSICARILAFSNSCVNPFALYLLSkSFRKQF 336

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