Conserved Protein Domain Family
7tmA_ET_R

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cd15128: 7tmA_ET_R 
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.
Statistics
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PSSM-Id: 320256
View PSSM: cd15128
Aligned: 4 rows
Threshold Bit Score: 544.038
Threshold Setting Gi: 119622
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##                ###
gi 119622    102 YINTVVSCLVFVLGIIGNSTLLRIIYKNKCmrnGPNILIASLALGDLLHIVIDIPINVYKLlaedWPFGae-----mCKL 176
gi 399458     81 YINTVISCTIFIVGMVGNATLLRIIYQNKCmrnGPNALIASLALGDLIYVVIDLPINVFKLlagrWPFDhndfgvflCKL 160
gi 45383870   91 YINTIVSCTIFIVGIIGNSTLLRIIYKNKCmrnGPNVLIASLALGDLLYILIALPINVYKLlakdWPFGvq-----vCKL 165
gi 617460647 136 YINTAFSFLIFAVGIIGNVTLLRIICQHKNmrnRPNALIASLAMGDILYIVIDGPINVYKLlameFPFAdqpfgqflCKL 215
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ### ##  #                                            # #####                    
gi 119622    177 VPFIQKASVGITVLSLCALSIDRYRAVASWsrIKGIGvPKWTAVEIVLIWVVSVVLAVPEAIGFdiitmdy-kgsylrIC 255
gi 399458    161 FPFLQKSSVGITVLNLCALSVDRYRAVASWsrVQGIGiPLITAIEIVSIWILSFILAIPEAIGFvmvpfey-kgeqhrTC 239
gi 45383870  166 VPFIQKASVGITVLSLCALSIDRYRAVASWsrIQGIGiPMWKAVEVTVIWAVAIVLAVPEAIAFdmveiny-wdqdlwVC 244
gi 617460647 216 LPFIQKTSVGITVLNLIALSVDRYRAVVSWsrIQSNGiPMETVVQIVMIWMLSALLAVPEAIGFnlhrfniasnvtisTC 295
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #  ### ### ##                                                     
gi 119622    256 LLhpvqktafmqFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLrkksgm-qialndHLKQRREVAKTVFCLVLVFAL 334
gi 399458    240 MLnatt--kfmeFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLnrrngslrialseHLKQRREVAKTVFCLVVIFAL 317
gi 45383870  245 MLaseqkssfmmFYRDVKDWWLFGFYFCLPLVCTGIFYTLMSCEMLskrngm-rialndHMKRRREVAKTVFCLVVIFAL 323
gi 617460647 296 LVrpet--sflkFYIKFKDWWIFGFYFCIPLTCSAIFYGLMTHELLrhekgdlkrslgeQLKQRREVAKSVFCLVVIFAL 373
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1         #  ## ##  #                 ## ###  #  ##                     
gi 119622    335 CWLPLHLSRILKltlynqndpnrcellsfLLVLDYIGINMASLNSCINPIALYLVSkRFKNCF 397
gi 399458    318 CWFPLHLSRILKktvydemdknrcellsfLLLMDYIGINLATMNSCINPIALYFVSkKFKNCF 380
gi 45383870  324 CWLPLHLSRILKktiydqtdpnrcellsfLLVMDYFGINMASLNSCINPVALYFVSrKFKNCF 386
gi 617460647 374 CWLPLHFSRLLKlmvydpndpgrcellniLLVLDYFSINLATINSCINPIILFFVSrKYRHYF 436

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