Conserved Protein Domain Family
7tmA_GPR142

?
cd15129: 7tmA_GPR142 
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.
Statistics
?
PSSM-Id: 320257
View PSSM: cd15129
Aligned: 6 rows
Threshold Bit Score: 452.694
Threshold Setting Gi: 632943715
Created: 6-Feb-2014
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##            ######
gi 83288229  157 VIPVIYYSVLLGLGLPVSLLTAVALARLATRtrrpSYYYLLALTASDIIIQVVIVFAGFLLQGavlarqvpqavVRTANI 236
gi 465953184  21 CWANTFNFSLCFVPAPVNILTAVALSRLAVRtkksSYWYLLALTASDILTQVIIIFMGFILQMailahegphafIHTFNV 100
gi 32165510   38 FIPVIYYSVLLCVGVPVNILTAVALTRLASRtrkaLYYYLLAVTGSDILSQLFIIFVGFLLETavfhrevpallLRSVSA 117
gi 512857340  16 IIPVIYYSILLCLGLPVNMLTAVALSRLASRtkksSYSYLLALTISDILSQIFIIFVGFILQTailhrkvpstlIHVVSV 95
gi 556952009  31 IIPIVYYSILLCLGLPVNLLTAIVLYRLVVKvkksSYCYLLALTSSDILTQFFIIFVGFILETaifhrqvpntlIHTVSI 110
gi 632943715  42 VIPLVYYSVLLCLGLPVNVLNTVVLSSLAAKtkksSYCYLLALSASDLLTQFFIVFVGFILEAgllarelpeamAHSVSV 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                            # #####                #  ### 
gi 83288229  237 LEFAANHASVWIAILLTVDRYTALCHPlhHRAASsPGRTRRAIAAVLSAALLTGIPFYWWldmwrdtdsprtlDEVLKWA 316
gi 465953184 101 LQFATNHASIWVTVLLTADRYVALCHPlrYRMLSyPERTRKIIAAVFGAALATGIPFYWWldiwhdsqppttvDKVLKWV 180
gi 32165510  118 AEFAANHASIWSAVPLTVDRYVALCHPllHRQISyPARTRRIIAMVLVLSLASGLPFFWWsdmwrnshpptalDAILIWT 197
gi 512857340  96 LEFSSNHASIWVTVILTVDRYVALCYPlqYRSFSyPERTRRVIVFVFLSSFVTGVPFYWWsdvwrdprtpgllDLILKWT 175
gi 556952009 111 LEFAANHASIWIAVLLTIDRYVALCHPliYRMVSyPERTRKIIAAVFILALITGIPFYWWsdvwrathppttlDKILIWM 190
gi 632943715 122 MEFAANHASIWITVPLTVDRYYALCHPlrYRAVSyPGRTYKVIATVFVASLLTGVPFYWWsdlwrvrspptplDQVLVWT 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ### ##                                                          #  ## ##  #     
gi 83288229  317 HCLTVYFIPCGVFLVTNSAIihrlrrr-----------grsglqPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYvap 385
gi 465953184 181 HCFTMYFIPCSIFLATNSVIvcklkwg----------krvdghhRRMGKTIAMLMAVTTIFTVLWAPRTCVILFHLYmgs 250
gi 32165510  198 HVTIIYFLPCSIFLVLNSLIihtlrarqrqqcsqdergpqsappRRLGKTTAMLLAITSVFSVLWAPRTVVVIYHLYvss 277
gi 512857340 176 HCFIIYFIPCTIFLITNSVIiyrlrkr----------tgskkcqLRNGKTTAILLGITSVFAVLWAPRTIVIIIHMYvss 245
gi 556952009 191 HCFIIYFIPCTIFLIVNSMIiyklkqk----------kestgrpLRSGKTTAILLAITTVFAILWAPRTIVIIYHAYvss 260
gi 632943715 202 HCFIIYFVPCTVFLVVNSIIvhklgr-------------rrapsGRSGKTTAILLAVTTVFAILWAPRTVVIIYHLYvss 268
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
Feature 1              ## ###  #  ##                     
gi 83288229  386 vhrdwrVHLALDVANMVAMLHTAANFGLYCFVSKtFRATV 425
gi 465953184 251 tskdqrLHVALNLANMIAMLNTTVNFFFYCFVSKtFRRTA 290
gi 32165510  278 vhrdwrVHLAYDLSNMLAMLNTAVNFFLYCFVSKpFRGAV 317
gi 512857340 246 vnkdwkVHLAMDIGNMLALLNTAVNFFLYCFVNRrFRDTV 285
gi 556952009 261 vnkdwqVHLAFDLANMLALLNTGINFFLYCFVSKrFRFVV 300
gi 632943715 269 vnrdwkVHLAFDLANMLAMTNTAVNFFLYCFVSKrFRVTV 308

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap