Conserved Protein Domain Family
7tmA_GHSR

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cd15131: 7tmA_GHSR 
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.
Statistics
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PSSM-Id: 320259
View PSSM: cd15131
Aligned: 4 rows
Threshold Bit Score: 526.375
Threshold Setting Gi: 157888794
Created: 24-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structure of Rattus norvegicus neurotensin receptor 1 with bound agonist neurotensin peptide, defined at 4A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #                #   
gi 3023860    43 AGVTATCVALFVVGISGNLLTMLVVSRFRElrttTNLYLSSMAFSDLLIFLCMPLDLVRLWqyRPWNFGdllCKLFQFVS 122
gi 45383368   25 TGITVACVLLFVVGVLGNLMTMLVVSRFRDmrttTNFYLSSMAFSDLLIFLCMPLDLFRLWqyRPWNFGdllCKLFQFIS 104
gi 157888794  47 MGITITCALLFLAGVTGNVMTILVVSKYRDmrttTNLYLCSMAVSDLLIFLCMPPDVYRLWkyRPWIFGdtfCKLFQFVS 126
gi 385145833  52 TGITVTCVFLFIIGIFGNIMTMLVVYKYKDmrttTNLYLSSMAFSDLLIFVCMPLDLYRLWqyRPWNFGsllCKLFQFIS 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                  #                     
gi 3023860   123 ESCTYATVLTITALSVERYFAICFPlrAKVVVtKGRVKLVILVIWAVAFCSAGPIFVLVGVEHengt------------- 189
gi 45383368  105 ESCTYSTILNITALSVERYVAICFPlrAKVIItKRKVKLVILILWAVSFISAGPIFVLVGVEHengt------------- 171
gi 157888794 127 ECCTYSTILNITALSVERYLAICFPlrAKRLVtKRRVRALIIFLWLVSLLSAGPVFVLVGVEHetrpaagnsvtaggaeg 206
gi 385145833 132 ESCTYSTILNITALSVERYFAICFPlkAKVVItKGRVKLVIFVLWAVSFVSAGPIFVLVGVEHengt------------- 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ####                                                                     
gi 3023860   190 -dprdTNECRAtefavrsGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRrrgdaav--gaslrdQNHKQTVKMLAVV 266
gi 45383368  172 -nplsTNECRAteyairsGLLTIMVWISSIFFFLPVFCLTVLYSLIGRKLWRrkrknig-pstiirdKNNKQTVKMLVVV 249
gi 157888794 207 qteidTSECKPtqyavesGLLAAMALVSSVFFFLPVFCLTVVYSLIGRRLWKrrrensiganvahrdKSNRQTVKMLAVV 286
gi 385145833 199 -npfeTNECKAteyavksGLLTIMVWTSSVFFFLPVFCLTVLYSLIGRKLWRrkretig-pcashrdKNNRQTVKMLAVV 276
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                     ##  ##             #   #                             
gi 3023860   267 VFAFILCWLPFHVGRYLFSksfepgsleiaqiSQYCNLVSFVLFYLSAAINPILYNIMSkKYRVAV 332
gi 45383368  250 VFAFILCWLPFHVGRYLFSksfeagsleiaviSQYCNLVSFVLFYLSAAINPILYNIMSkKYRVAA 315
gi 157888794 287 VFAFVLCWLPFHLHRYLMShssegssplwslfTQYCSLVSTVLFYLSAAINPVLYNTMSrKYRSAA 352
gi 385145833 277 VFAFVLCWLPFHVARYLFSksfeagsleialiSQYCNLVSFVLFYLSAAINPILYNIMSkKYRVAA 342

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