Conserved Protein Domain Family
7tmA_NMU-R

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cd15133: 7tmA_NMU-R 
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.
Statistics
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PSSM-Id: 320261
View PSSM: cd15133
Aligned: 4 rows
Threshold Bit Score: 445.435
Threshold Setting Gi: 74761608
Created: 24-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structure of Rattus norvegicus neurotensin receptor 1 with bound agonist neurotensin peptide, defined at 4A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #                #  
gi 74761608  61 MPICATYLLIFVVGAVGNGLTCLVILRHKAmrtPTNYYLFSLAVSDLLVLLVGLPLELYEMwhNYPFLLGvggCYFRTLL 140
gi 9082156   43 LPVSVVYVPIFVVGVIGNVLVCLVILQHQAmktPTNYYLFSLAVSDLLVLLLGMPLEVYEMwrNYPFLFGpvgCYFKTAL 122
gi 47220933  61 FPVCLTYMVIFVVGVVGNLLTCSVIARNKMmwtPTNYYLFSLAVSDLLVLLLGMPLELYELwqNYPFLLGsggCYFKTFL 140
gi 47217151  26 FPVTSVYLLIFLVGLSGNVLTCTVIARHKKmrnPTNLYLLSLALSDLLVLLFGMPLEIYELwqNYPFPFGeggCYFKTFL 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                  #                 ###
gi 74761608 141 FEMVCLASVLNVTALSVERYVAVVHPLQARSMVtRAHVRRVLGAVWGLAMLCSLPNTSLHgirqlhvpcrgpvPDSAVCM 220
gi 9082156  123 FETVCFASILSITTVSVERYVAILHPFRAKLQStRRRALRILGIVWGFSVLFSLPNTSIHgikfhyfpngslvPGSATCT 202
gi 47220933 141 FETVCLASILNVTALSMERYIAVVHPLAQSTCNpHPRSTGHPGCMGRVGLVCAAEHESPRdp---------gpPASLQQR 211
gi 47217151 106 LETVCFASILNVTALSVERYIAVLHPLKSRYLStNQHVKRVIAVVWVVSMICAVPNTSLHglfyl----pqrmEESAICT 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #                                                                               
gi 74761608 221 LVRpr-------------alYNMVVQTTALLFFCLPMAIMSVLYLLIGLRlrrerlllmqeakgrgsaaarsrytcrlqq 287
gi 9082156  203 VIKpm-------------wiYNFIIQVTSFLFYLLPMTVISVLYYLMALRlkkdkslea--------------degnani 255
gi 47220933 212 HRKlqhgnprlghlhaseaaLDVQPDHTGHHFVVFCPAHAHHHCLLHAHWaaveagedatgags-----kigtrtgqllq 286
gi 47217151 182 VLKpi-------------wiYNMIMQITTVCFFFAPMMVISVLYLVMGLHlgrerghssrsf--------eensvhgkma 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                   ##  ##            #   #                             
gi 74761608 288 hdRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSvvsqwtdglhlaFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETF 367
gi 9082156  256 qrPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSfveewseslaavFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAF 335
gi 47220933 287 hpFTAAEGTSPTVILVVVFAICWAPFHTDRLMWSfisdwtanhheiFQYVHIISGVLFYISSAVNPILYNLMSTRFREMF 366
gi 47217151 241 gsRRRTQVNKMLSIVVAVFGLCWAPFHIERLLWSsishwtdlmhsvYQYVHIVSGFFFYLSSAVNPIIYSLLSTRFRECF 320

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