Conserved Protein Domain Family
7tmA_PGI2

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cd15141: 7tmA_PGI2 
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.
Statistics
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PSSM-Id: 320269
View PSSM: cd15141
Aligned: 4 rows
Threshold Bit Score: 477.39
Threshold Setting Gi: 1172500
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    #  ##               
gi 1172500    14 SVGPATSTLMFVAGVVGNGLALGILSARRPar---pSAFAVLVTGLAATDLLGTSFLSPAVFVAYarnsSLLGLArggpa 90
gi 189528705  16 NGNPGTSTVMFIAGVVGNLIALAILGVHQKdrrtksSVFCILVTGLALTDLLGTCLLSPPVFICYayrtSLVGLTgd-qr 94
gi 465956722  32 DGSPVLSSLMFSAGVAGNVVALAILGVHRKelrtksSAFCILVTGLAATDLLGTCFLSPVVFVSYahnaSLLGLAeggrs 111
gi 301606072  14 DGHPAVSTLMFAGGVVGNLLALGILGVHRRerraraSPFWVLVTGLAVTDLLGTCILSPMVFVSYaqqsSILALGaa--p 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ###### ##  #                                             # #####               
gi 1172500    91 LCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYlYAQLDg-PRCARLALPAIYAFCVLFCALPLLGlgqHQQYCPGSW 169
gi 189528705  95 LCGLFAFAMTFFILASMLILCAMAVERCLAISHPYfYSKHVr-RSFAKIVLLLIYLFTFVFCLMPFFGygrHKQYCPGTW 173
gi 465956722 112 LCQLFAFAMTFFGLASMLILCAMAVERCLAISHPYfYSQHNg-RGWAKLALPAVYAFSALFCCLPLLGvgrHKQYCPGTW 190
gi 301606072  92 LCHLFAFAMTFFSLASMMLLFCMALERCLAISHPYvYAQHSwgHRLAHAAIPVSYVLGALLCALPLVGvgeHKQYCPGTW 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #  ### ### ##                                                    
gi 1172500   170 CFLrmrw-----aqpGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCrmyrqqkrhq---------gslgprprtGEDEV 235
gi 189528705 174 CFIkmeveegddeerRSLAFSLSYAVLMALLIAIVFMCNGSVIVSLCrmhrsqltrrgsvvsagrkrrlstwfgqGEEEM 253
gi 465956722 191 CFVemas-----grpSSAAFSLTYATLMAFLILAIFLCNGSVIVSLCqmyrkqrarrgsl--gpaqrrgkswlsqGEEEV 263
gi 301606072 172 CFIrmtvp--ghresGALAFSLLYASLTGLLIVAIVICNTSVTASLCrmrkgqkarrgsl---rrcgargwllgaGEEEL 246
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                        #  ## ##  #       ## ###  #  ##                      
gi 1172500   236 DHLILLALMTVVMAVCSLPLTIRCFTQavapdssSEMGDLLAFRFYAFNPILDPWVFILFRKaVFQRLK 304
gi 189528705 254 DHLLLLASMTLIFVICSLPLTICGFENais-pvgNDQRNLTAFRFSAFNPILDPWIFIIFRKaVFHHIR 321
gi 465956722 264 DHLVLLALMTIIFVICSLPLTIRAYIGgla-pdgYEKGDMVAFRFSALNPILDPWIFILFRKaVFRSLR 331
gi 301606072 247 EHLILLVLMTVIFMVCTVPLTLRAFLGaiy-eddNESADLLAFRFSAFNPILDPWIFIIFRGsVFRKLR 314

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