Conserved Protein Domain Family
7tmA_TXA2_R

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cd15143: 7tmA_TXA2_R 
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.
Statistics
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PSSM-Id: 320271
View PSSM: cd15143
Aligned: 4 rows
Threshold Bit Score: 443.106
Threshold Setting Gi: 47216591
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                     #  ##              
gi 229463010  25 IASPWFAASFCVVGLASNLLALSVLAGARQggs-htRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHaalfeWHAVDPGCr 103
gi 465954809  32 IVSRWFSTAFGSIGLASNLFALCVLVSSSRkmhsraRSSFLIFLCGLVVTDFLGLLVTGTIIISYHftkfnWMVVDPACy 111
gi 50416233    7 ITSLWFSTIFSIIGLCSNLFAFYVLVNASRktrsrsRSSFLIFLCGLVVTDFMGLLVTGIIVVSNHvtqfdWQVFDQNCy 86
gi 47216591   15 ITSVSFSSIFSALGLFSNFIAFIVLVKSFHrtksrsRSSFLIFLGGLVVTDFLGLLVTGSIVISFYltnfnWRLLDPDCh 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ###### ##  #                                            # #####                
gi 229463010 104 LCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFsRPAVAsQRRAWATVGLVWAAALALGLLPLLGVGrytvQYPGSWC 183
gi 465954809 112 LCNFLGLSMVFFGQCPLLLGATMAGERFFGINRPFsRSTSMsKRRAWFMVGMVWAFSFSLGLLPILGLGdytlQYPNSWC 191
gi 50416233   87 LCNFFGLSMVFYGQCPLILGAAMAAERFFGINKPFsRSATVsKKRACGIVVMVWCFAFFLGILPIMGVGrytlQYPKSWC 166
gi 47216591   95 FCNFMGMSMVFYGLCPLLLGATMAVERFIGINCPFvRFTAMpKSRTVYMLLTVWLVAGLIALLPITVLGsyhlQSPGSWC 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #  ### ### ##                                                     #  ## 
gi 229463010 184 FLtlgaesGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLchvyhgqeaaqQRPRDSEVEMMAQLLGIMVVASVCWLPLLV 263
gi 465954809 192 FItllhdaKNVTFCLIFALLGILAVGLSFLFNTVSVVTLcrvyh-dresvQRRRDSEVEMMVQLVGIMIIATVCWLPLLI 270
gi 50416233  167 FLtllqdsKNKLFGLIFSFIGIFSVSLSFILNTISVVTLcrvyh-dresvQRRRDSEVEMMVQLVGIMIIASLCWLPLLI 245
gi 47216591  175 FFnisfqgSDQAFSLLFSFTGLLSIAVSFVLNTVSFITLikvcc-kqdrrQRRRDHEIEMMVQLLLIMVIESICWCPLLV 253
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1        ##  #                 ## ###  #  ##                      
gi 229463010 264 FIAQTVLrnppamspagqlsrtTEKELLIYLRVATWNQILDPWVYILFRRaVLRRLQ 320
gi 465954809 271 FIIQTVLqepapgllprhiprqTQEMLLIYLRMVTWNQILDPWVYILFRRaVLKRIY 327
gi 50416233  246 FIAQTVLqhpsgelleeeiprsTEKFLLIYLRIATWNQILDPWVYILFRRaVLKRVY 302
gi 47216591  254 FIAQTVLlkq----------plNVKKLLLFIRFATCNQILDPWVYILFRRaVIKRLY 300

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