Conserved Protein Domain Family
7tmA_FP

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cd15145: 7tmA_FP 
prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The PGF2-alpha receptor, also called prostanoid FP receptor, is a class A G-protein coupled receptor whose endogenous ligand is prostaglandin F2-alpha. PGF2-alpha binding to this receptor is coupled to the stimulation of phospholipase C (PLC) pathway via G-protein subunit G(q). This leads to the release of inositol trisphosphate (IP3) and diacylglycerol (DAG) which results in increased intracellular Ca2+ levels and activation of PKC. The receptor activation primarily induces uterine contraction and bronchoconstriction, and stimulates luteolysis. Like most prostanoid receptors, the PGF2-alpha receptor has also been implicated in tumor angiogenesis and metastasis.
Statistics
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PSSM-Id: 320273
View PSSM: cd15145
Aligned: 5 rows
Threshold Bit Score: 433.48
Threshold Setting Gi: 296279061
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                     #  ##              
gi 1172442    27 RLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRqksKASFLLLASGLVITDFFGHLINGAIAVFVYasdKEWIRFDQSnv 106
gi 113206100  25 KISVFFSIIFMTVGILSNSLAIAILMKAYQRFRqksKASFLLLASGLVITDLFGHLINGAIAVFVYasdKDWIRFNQSni 104
gi 296279061  24 EVSVTSTGISMTVGIVSNTLALFILIKAYHRFRyksKAAFLLFASGLVITDFLGHLINGSLALYVYvsqKEWETFDNHks 103
gi 162423726  17 KYQYFFSIIFMTVGIISNSLAIAILLKAYQRFRkksKASFLLFASGLVITDLFGHLINGTIAVFVYaskRDWLQFDQSni 96
gi 2495016    27 DLSISFSIIFMTVGILSNSLAIAILMKAYQRFRqkyKSSFLLLASALVITDFFGHLINGTIAVFVYasdKDWIYFDKSni 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ###### ##  #                                            # #####                
gi 1172442   107 LCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPiFHSTKItSKHVKMMLSGVCLFAVFIALLPILGhrdYKIQASRTWC 186
gi 113206100 105 LCSVFGICMVFFGLCPLFLGSVMAVERCIGVTKPiFHSTKMtSKHVKMMLTMVCLFAVLIALLPILRfraYQIQASRTWC 184
gi 296279061 104 LCDFFGVCMAFFGLTPLLLGCLMAVERCIGVTRPlFHTTALgSHHVKRLLGVTWLLGLLVALLPVLFqrsYQVQRSRSWC 183
gi 162423726  97 VCSVFGMCMVFFGLCPLLLGSVMAVERCIGVTQPiFHSTKMtSKHVKIILSLVWLFAILVALMPILTargYHIQASRTWC 176
gi 2495016   107 LCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPiFHSTKItTKHVKMMLSGVCFFAVFVALLPILGhrdYKIQASRTWC 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                                        #
gi 1172442   187 FYntedikDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRvkfksq----qhrqgrSHHLEMVIQLLAIMCVSCICW 262
gi 113206100 185 FYktehveDWEDRFYLLLFSSLGLLALAISFLCNAVTGITLLRvkfksq-----qrqgrSHHFEMIIQLLAIMCVSCICW 259
gi 296279061 184 FFrlqgprDWMDTLLPILFSALGLLALLVSLLCNTMTFLTLLRsrvqldrnnhrhsrkaSHHSEMVCQLLAIMLVSCVCW 263
gi 162423726 177 FIktehieEWRDQFNLLLFSFLGILSLAISFLCNAITGITLLRskirnh----qyrqgrSHHIEMIIQLLAIMCVSCICW 252
gi 2495016   187 FYktdqikDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKvkfrsq----qhrqgrSHHFEMVIQLLGIMCVSCICW 262
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1          ## ##  #          ## ###  #  ##                      
gi 1172442   263 SPFLVTMANIgingn-hsleTCETTLFALRMATWNQILDPWVYILLRKaVLKNLY 316
gi 113206100 260 SPFLVSMARIginas-hskeNCETILFALRMATWNQILDPWVYILLRKaVLKNLY 313
gi 296279061 264 GPILITAIIFslqdrgedqtSYTHMLLVVRMATWNQILDPWVYILLRKaVLRRLF 318
gi 162423726 253 TPFLVTMANIvfkgd-dplqTRETILFSLRMATWNQILDPWVYILLRKtVLKKLF 306
gi 2495016   263 SPFLVTMASIgmniq-dfkdSCERTLFTLRMATWNQILDPWVYILLRKaVLRNLY 316

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