Conserved Protein Domain Family
7tmA_PAFR

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cd15147: 7tmA_PAFR 
platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.
Statistics
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PSSM-Id: 320275
View PSSM: cd15147
Aligned: 8 rows
Threshold Bit Score: 468.462
Threshold Setting Gi: 47230010
Created: 18-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##            ######
gi 129557     16 TLFPIVYSIIFVLGVIANGYVLWVFARLYPckkfnEIKIFMVNLTMADMLFLITLPLWIVYYQnqGNWILPkflCNVAGC 95
gi 47230010   16 DLFPSAYGVIFILGLLANLYVLFILRCLQEaramgEIRIYMTNLSIADLLFVCALPFWIGYYSrhGNWVYTdfmCRLTGS 95
gi 129556     16 TLFPIVYSIIFVLGIIANGYVLWVFARLYPskklnEIKIFMVNLTVADLLFLITLPLWIVYYSnqGNWFLPkflCNLAGC 95
gi 148225482  26 SLFTVTYSIIFVFGFIANCYVLWIFGRVYPaknlsEIKIFMINLTIADLLFLVTLPLWIVYYHyeGDWFMPsflCNVAGC 105
gi 125842313  26 TLFPIFYGVVFVLGLIANCYALYVLHRMREskamnEIRIYMTNLTVADLLFVSALPFWIDYYMheGHWRSTeafCRITGT 105
gi 3024366    16 TLFPIVYSVIFILGVVANGYVLWVFANLYPskklnEIKIFMVNLTMADLLFLITLPLWIVYYYneGDWILPnflCNVAGC 95
gi 449267778  28 NLFTVFYSIIFILGFAANCYVLWIFSRIYPtkklnEIKIFMVNLTVADLLFLVTMPMWIVYYHhhGDWIMPkflCNVAGC 107
gi 387914360  31 ILFPVVYSIIFLLGLMGNCYVLWVFKHLSMsrninEVKTFMVNLSIADLLFILTLPFWIVYYCglGNWVFPeffCRMVGC 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                            # #####                       
gi 129557     96 LFFINTYCSVAFLGVITYNRFQAVTRPikTAQANtrKRGISLSLVIWVAIVGAASYFLIldstntvpdsagsgnvTRCFE 175
gi 47230010   96 LFFINTYCSVLFLGAISVNRYWAVTRPldTASSDhrLRGIIISVIIWVLTISMAIPYLVspatnt-----denlvVRCFE 170
gi 129556     96 LFFINTYCSVAFLGVITYNRFQAVKYPikTAQATtrKRGIALSLVIWVAIVAAASYFLVmdstnvvsnkagsgniTRCFE 175
gi 148225482 106 FFFLNTYCSVAFLGVISYNRFQAVTRPveTAQSTarIRGICISVAVWILLFASSLYFLIfpgtniv--nidgknfTRCFE 183
gi 125842313 106 FFFINTYGSILFLTVISINRYWAVTKPlkAASSDcwKRGAIISVLIWAFILSASIPQLTkegiqke--qrmnrsmQRCFE 183
gi 3024366    96 LFFINTYCSVAFLGVITYNRYQAVAYPikTAQATtrKRGISLSLIIWVSIVATASYFLAtdstnlvpnkdgsgniTRCFE 175
gi 449267778 108 LFFVNTYSSVAFLMVITYNRYQAVTNPikAAQFTtqRRGIYLSAAIWIIIVGSSLYYLFddntnee--kidsknfTRCFE 185
gi 387914360 111 LFLINTYCSIAFLAAISYNRYCAVARPieSIQQSgrKRGMIVSFAIWFIILCSASPFLFmkstn------qvgtqTHCFE 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                                        
gi 129557    176 HYekg----svPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLlmqpvq------------qqrnaEVKRRALWMVCTVLA 239
gi 47230010  171 GYqnqtdsekkTVAATHFAIIGLFFVVFALVLVCNLLIAQALlssnakslqhtgssrstssqrprGVKRRALQMLLAVVG 250
gi 129556    176 HYekg----skPVLIIHICIVLGFFIVFLLILFCNLVIIHTLlrqpvk------------qqrnaEVRRRALWMVCTVLA 239
gi 148225482 184 GYsid---nrePVAVIHFILVGAFFVVFLIILTCNLVIARTLlyqpvk------------srkssDMKHRALWMVVTVLA 248
gi 125842313 184 GYhytdentknVLVITHFSIIGLFFLVFLMVIICNISIARALlsqpisqpr------astgrrpgGTKRRALRMLCAVIG 257
gi 3024366   176 HYepy----svPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLltqpmr------------qqrkaGVKRRALWMVCTVLA 239
gi 449267778 186 RYdssg--nvsAVLAIHVIICVLFYIIFFFILGWNVIIIRTLfskpaq------------prrsaHVKQRALWMVCTVLA 251
gi 387914360 185 GYdrd---ssmAVMISNFVLITAFFFAFLVIVVCNLHILRLLstqtiq-----------pgntnhSVKQQAFRMVCAVMV 250
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1             #  ## ##  #                       ## ###  #  ##                     
gi 129557    240 VFIICFVPHHVVQLPWTLaelgfqd--------skfhqaINDAHQVTLCLLSTNCVLDPVIYCFLTkKFRKHL 304
gi 47230010  251 VFVVCFLPHHVIQGAWTLavlqikqgwghvdwsqgtrqaLNDAHQITLLLMGLNCILDPVVYCFATkKFRRYI 323
gi 129556    240 VFVICFVPHHMVQLPWTLaelgmwp--------ssnhqaINDAHQVTLCLLSTNCVLDPVIYCFLTkKFRKHL 304
gi 148225482 249 VFVLCFVPHHIVDGPWTLtvlrmwhe-----tdcdfrkmLNNVHQITLCLMSTNCMLDPIIYCFLTkKFRKHL 316
gi 125842313 258 VFVICFLPHHVVQGPWVLsvlqlkky-----wstwthqtLNDAHQITLMLMGINCLLDPLVYCFATtKFRKYL 325
gi 3024366   240 VFIICFVPHHVVQLPWTLaelgyq---------tnfhqaINDAHQITLCLLSTNCVLDPVIYCFLTkKFRKHL 303
gi 449267778 252 VFIISFVPHHIVHLPWTLtvleqwrk-----edcqlrqqLNDAHQVTLCLLSMNCVLDPIIYCFLTkKFQKHL 319
gi 387914360 251 VFSLCFLPHHVVQGPWTLtvleqwrv-----ddcqfrqaVNDAHQVTLCLMSLNCALDPIIYCFLTkKFRRFL 318

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