Conserved Protein Domain Family
7tmA_GPR34-like

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cd15148: 7tmA_GPR34-like 
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320276
View PSSM: cd15148
Aligned: 8 rows
Threshold Bit Score: 453.381
Threshold Setting Gi: 34538247
Created: 18-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##            ###### #
gi 12643337   55 TVLTTSYSVIFIVGLVGNIIALYVFLGIHRkrnsIQIYLLNVAIADLLLIFCLPFRIMYHInqnkWTLGvilCKVVGTLF 134
gi 34538247   34 LPLAAMYSLFFVFGLVGNLAALWVFLFQRSsnnsLRLFLINCAVADLVLLGCLPFRISYHLngdqWHLGplaCKMVGNLF 113
gi 190570276  31 IPLAVFYTLFFLFGFAGNLLALWVFLRLHPkknsVRIFLINLALADILLVICLPFRVAYHFnnnqWVLPsllCRIVGNVF 110
gi 190337034  34 LPLAVLYSLIFLFGLLGNLLALWVFLFLHRrrnsVRVFLINVALADLVLLACLPFRVLYHAlgnvWTLGprmCRVVGNLF 113
gi 194332475  47 TALAVLYSIIFVFGLLGNILAIYVFLFIHSkrnsVQVYLLNTAIADLLLIICLPFRIMYHVsq-nWKLGivfCKVVGNLF 125
gi 124249290  47 FALISFYSVIFVIGLVGNIIALFAFLCIHQkrnsIQVYLLNVAIADLLLIFCLPFRILYHIsnntWMFGwilCKIVGTLF 126
gi 34538209   34 VPLAIFYSLFFLFGLSGNLLALWVFLRVHPkknsVRIFLINLALADLLLVICLPFRVIYHSnndqWVLPsllCTMVGIIF 113
gi 612016597  48 VVLTISYSIIFIVGLVGNIIALYVFLGIHRkrnsIQIYLLNVAIADLLLIFCLPFRILYHVnknmWTLGvifCKTVGTLF 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                                   # #####                  
gi 12643337  135 YMNMYISIILLGFISLDRYIKINRSiqQRKAITt-------KQSIYVCCIVWMLALGGFLTMIIltlkk-gghnsTMCFH 206
gi 34538247  114 YMNMYISIMLLGFISLHRYLRIKGKgrARQGITvkllghrcPWSWVACGTLWSLSLVGLVPMIVmaed---eehsNKCFQ 190
gi 190570276 111 YMNMYISIALLGFISVDRYLKFHRAs-SRRWFLq------sHWSAIVCGVLWAVSIAGVSPFIVkten---nnetHQCFQ 180
gi 190337034 114 YMNMYVSITLLGLISLDRYLKIMGSh-RGRRWLrg-----rSWSLVTCGLLWGLSVLMAVPMMAlaeg---neepGKCYQ 184
gi 194332475 126 YMNMYISIVLLGLISMDRYIKVKKSl-RRNKVSd------rKCSIQACCVLWIVAVVAVMFLIAtqssk-kqsnsNLCFQ 197
gi 124249290 127 YMNMYISIILLGLISLDRYVKINKSv-KRPKMLt------tTRSVHICCIVWAVALTGFSLVVVpslfrsdisnsTLCFH 199
gi 34538209  114 YMNMYISIVLLGFISVDRYLKVQRSs-CRQVFLq------sRWSVLLCNVIWAVAFVCGICFIVldte---hgesQQCFQ 183
gi 612016597 128 YMNMYISIILLGLISLDRYIKINRSihQQKALTt-------KQSIYICGIVWALAITGFLTMIIstikk-gghdsTMCFH 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #  ### ### ##                                                   #  ## #
gi 12643337  207 Yrdkh-nakGEAIFNFILVVMFWLIFLLIILSYIKIGKNLlriskrrskfpnsGKYATTARNSFIVLIIFTICFVPYHAF 285
gi 34538247  191 FkmrsgngkGKAIFNVLVVVFFWLVFIMLVVSYVKIASKLlrvswdkpdlpnaHRYQRSAKKSFFVLFLFIVCFGPYHAF 270
gi 190570276 181 Ykklc-dskWKAYFNFVIVAIFWVVYGALVMSYGRIGMKLitasrdkpdfpnaAKYNKTAWKSFFVLFTFTVCYAPYHFV 259
gi 190337034 185 Ykqrk-harGKAYFNLLMVAVFWLVFVVLLVSYGQIARRLlrasqdkphlpnaARYARTARKSFVVPLLFTVCFVPYHAF 263
gi 194332475 198 Ysdrk-deiWQAVFNYLLVLVFWIVFLSLILSYVKIAKNLfrisrerahlpnaGRYSCTAQKSFFVLFIFTLCFVPYHTF 276
gi 124249290 200 Yrnkk-namTEAILNYIIVIMFWTVFLLLILSYVKIAKNLlkisrkranfpnaVKYTQTARNSFIVLIIFTVCFVPYHMF 278
gi 34538209  184 Ykhly-eskWKAYFNFAIVGMFWLVYGALVISYGRIGMKLlsasrekpdfpnaAKYNKTAWXSFFVLFLFTICFVPYXSV 262
gi 612016597 200 Yrdkh-nakGEAIFNYIIVIIFWLVFLLLILSYIKIANYLlkiskkrvnfpnsGKFHTTARNSFIVLIIFTICFVPYHGF 278
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
Feature 1        #  #                ## ###  #  ##                     
gi 12643337  286 RFIYISSQlnvssc-ywkeiVHKTNEIMLVLSSFNSCLDPVMYFLMSsnIRKIM 338
gi 34538247  271 RPVYIFYQiknnqpceilqmVARTNEIMLLLSAFNSCLDPVMYFILSgsVRKST 324
gi 190570276 260 RIFYIMSQmapnvscnkmnvLDKTNEVVLLLSALNSCLDPVMYFLLCssIRKVT 313
gi 190337034 264 RGFYVASQlqdisc-etrrlMDRTNEAVLLLSALNSCLDPVMYFLLSgsVRRAT 316
gi 194332475 277 RIAYITSQlqkhsc-ywtdiIHKTNEIMLVFSALNSCLDPVMYFLLSssIRKTV 329
gi 124249290 279 RFVYITSQlqnpsc-ywkgiIHTCNEVMLIFSSFNSCLDPVMYFLMSssVRKTV 331
gi 34538209  263 RIFYIMSQiantsc-ewisvLDKTNEEVLLLSAFNSCLDPVMYFLFCssIRKVI 315
gi 612016597 279 RFIYITSQlnttpc-ywkeiFHKINEIMLVLSSFNSCLDPVMYFLMSsnIRKII 331

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