Conserved Protein Domain Family
7tmA_GPR174-like

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cd15152: 7tmA_GPR174-like 
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320280
View PSSM: cd15152
Aligned: 6 rows
Threshold Bit Score: 473.828
Threshold Setting Gi: 528499453
Created: 18-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##           ###### ##
gi 21263618   20 FIYAVTYTVILVPGLIGNILALWVFYGYMKEtKRAVIFMINLAIADLLQVLSLPLRIFYYLnhdWPFGpgLCMFCFYLKY 99
gi 56605922   15 PYYAITYAFILIPGLIGNVLALWVFYGYMKEtKRAVIFMINLAIADLSQVLSLPLRIFYYLtgtWEFGggLCMLCFYLKY 94
gi 528499453  19 QIYAVFYTLILIPGLIGNVLALWIFYAYVKEtKKAVIFMINLAIADLLQVLSLPLRVYYYLnnsWPFGkaACMICFYLKY 98
gi 556997865  14 FYYAVTYSIILVPGLIGNVLALWVFYAYIKEtKKAVIFMINLAIADLAQVLSLPLRIFYYLhkhWPFGdfLCMACFYLKY 93
gi 632935509  15 FLYAIVYTVILIPGFIANLLALWVFYAYVKEtKRAVIFMINLAVADLAQVLSLPLRIFYYLnktWYFGkfLCIFCFYLKY 94
gi 512863470  20 NIYAITYTIILIPGLIGNVLALWIFYAYIKEtKRAVIFMINLSIADLMQVLSLPLRIFYYLnqsWPFShfVCMFCFYLKY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                           # #####                           
gi 21263618  100 VNMYASIYFLVCISVRRFWFLMYPfrFHDCKqKYDLYISIAGWLIICLACVLFPLLRtsddtsgnrTKCFVDLPtrnvnl 179
gi 56605922   95 VNMYASIFFLVCISVRRFLFLMYPfrFSDCKrVCDVYISIVGWVVVCVGCLPFPLLRltq---natNACFADLPvqevdl 171
gi 528499453  99 VNMYASIYFLACISLRRCRLIFKPl-SCDIMkGQDRRWCFVGWFVVCVGCLPFPLLRqse---rnpQCCFAELPmmqlkk 174
gi 556997865  94 VNMYASIYFLVCISVRRCMILIYPlrYNNCKrKCDVFISVAGWLVVGICCLPFPIMRqykd--enyTICFSDLPlrnvga 171
gi 632935509  95 VNMYASIYFLVCISVRRCLYLIYPfrYNDCKrRYDVYVCIIGWIAVGLGCLPFPLMRleqn-qtnfSSCFADLPlkdvgt 173
gi 512863470 100 VNMYASIFFLVCISVRRFLYVIYPfkWNDRKrVCDVYISVAGWITVCVSCLPFPLLRvsnd-tttnDRCFVDLPlvdigm 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #  ### ### ##                                                #  ## ##  #      
gi 21263618  180 aqSVVMMTIGELIGFVTPLLIVLYCTWKTVLSLqdkypmaqDLGEKQKALKMILTCAGVFLICFAPYHFSFPLDFLVKsn 259
gi 56605922  172 ptSVIMMTIGELVGFVTPLLIILYCSWKTVLSLkernsaspDLGEKKKALKMILTCALVFLICFAPYHISFPLDFFVKtk 251
gi 528499453 175 elGVSLLAVAEMTGFLLPLAIVITCTWLTTASLrektcllhDTGEKHKALKMVLSCACVFMICFVPYHITFPLDFLTKsn 254
gi 556997865 172 taSVLMLVIGELVGFVLPLVIVVLCSWKTAMSLrdtnpvlnDSGEKKKALKMILTCAVVFLICFAPYHFSFPFHFLEMgk 251
gi 632935509 174 ttSIIMVTLAELTGFVVPLIVTGICSWKTIMSLrent-vlqDHGEKRKALKMILTCTIVFLICFVPYHISFPLAFLTKsg 252
gi 512863470 179 nnSVLLVTLAELFGFVTPLLIVLYCSWRTVMSLrepdsisqDLGEKKKALKMILTCAVVFLICFAPYHFSFPLDFLVKan 258
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
Feature 1                   ## ###  #  ##                     
gi 21263618  260 e-iksCLARRVILIFHSVALCLASLNSCLDPVIYYFSTnEFRRRL 303
gi 56605922  252 k-iknCCIQEVISVFHAVALCLASLNSCVDPILYYFTTdEFRRRL 295
gi 528499453 255 f-nmsATFKNAVLHVHPITLCLASLNCCLDPVMYYFTTdEFKRRL 298
gi 556997865 252 kvnsdCRSRKVITVIHLVSLCLASLNSCLDPIIYYFTTdEFKRRL 296
gi 632935509 253 k-ienCSARKFIDIFHPVALCLASLNCCLDPIIYYFTTdEFRRRL 296
gi 512863470 259 k-itqCKQRKAILTLHPVALCLASLNSCLDPVIYYFTTdEFKRRL 302

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