Conserved Protein Domain Family
7tmA_LPAR4

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cd15155: 7tmA_LPAR4 
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.
Statistics
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PSSM-Id: 320283
View PSSM: cd15155
Aligned: 4 rows
Threshold Bit Score: 471.328
Threshold Setting Gi: 47210988
Created: 18-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##           ###### ##
gi 147901001  19 NLYGAVYSVVFIFGLITNCASLFVFCFKMKmqnETAIFMTNLAVSDLLFVFTLPFKIFYNFnrHWPFGDslCKISGTAFL 98
gi 2495042    40 NLNGAVYSVVFILGLITNSVSLFVFCFRMKmrsETAIFITNLAVSDLLFVCTLPFKIFYNFnrHWPFGDtlCKISGTAFL 119
gi 47210988   23 NLYSVVYSVVFVLGLITNCAALFVFCFRMKmrnETTMFMTNLALSDLVFVFTLPFKVFYNVnrHWPFGDglCKVSGTAFI 102
gi 449269939  19 NLYGAVYSVVFILGLITNCASLFVFCFRMKmrsETAIFMTNLAVSDLLFVFTLPFKIFYNFnrHWPFGDslCKISGTAFL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                            # #####                          
gi 147901001  99 TNIYGSMLFLTCISVDRFLAIVYPFrSRTIRtrRNSAIVCACVWIIVLSGGISASLFSTTNvsntsTTCFEGFSKsiwkt 178
gi 2495042   120 TNIYGSMLFLTCISVDRFLAIVYPFrSRTIRtrRNSAIVCAGVWILVLSGGISASLFSTTNvnnatTTCFEGFSKrvwkt 199
gi 47210988  103 TNIYGSMLFLTCISVDRFLAIVYPFrSRAIRtrRNAALVCAAVWLTIVGGGISVTFFSTINststaTTCFEGFSKstwrt 182
gi 449269939  99 TNIYGSMLFLTCISVDRFLAIVYPFrSRTIRtrRNSAIVCAGVWILVLSGGISASLFSTTNisnssTTCFEGFSKriwkt 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ### ### ##                                                #  ## ##  #       
gi 147901001 179 YLSKITIFIEVVGFIIPLLLNLTCSSLVLRTLRKPatlcqigTNKEKVLKMIVVHVAIFVVCFVPFNSILFLYALVRsqa 258
gi 2495042   200 YLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPatlsqigTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRsqa 279
gi 47210988  183 YLSKITIFIEIVGFLLPLLANLVCSSLVLRTLQRPvtvahgcDSKRRVLRMILVHLGIFIICFVPYNSILFLYALVRtqa 262
gi 449269939 179 YLSKITIFIEVVGFIIPLLLNLTCSSLVLRTLRKPatlsqigTNKEKVLKMIIVHVAIFVVCFVPYNSILFLYALVRsqa 258
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
Feature 1                 ## ###  #  ##                     
gi 147901001 259 isncaveRFARTMYPITLCIATMNCCFDPFVYYFTSkSFQKSF 301
gi 2495042   280 itncfleRFAKIMYPITLCLATLNCCFDPFIYYFTLeSFQKSF 322
gi 47210988  263 lascgveRFARTLYPITLCLATLNCCLDPVVYYFTSeSFQKSL 305
gi 449269939 259 iancsleRFARTMYPITLCIATMNCCFDPFIYYFTSeSFQKSF 301

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