Conserved Protein Domain Family
7tmA_CysLTR2

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cd15157: 7tmA_CysLTR2 
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320285
View PSSM: cd15157
Aligned: 8 rows
Threshold Bit Score: 425.665
Threshold Setting Gi: 663257852
Created: 18-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##            ###### #
gi 20138034   39 EFFPIVYLIIFFWGVLGNGLSIYVFLQPYKkstsVNVFMLNLAISDLLFISTLPFRADYYLrgsnWIFGDlaCRIMSYSL 118
gi 483518343  34 AIYPVMYLFIFFLGVVGNSLSIYVFFQPSQrktsVNIYMQNLAVSDLMFASTLPFRASYYLlgshWIFGDiaCRIMTYAL 113
gi 557019034  45 YVYPSTYIIFSVVGLIENGFSFYIFMQPHKkatsINIFLLNLVVSDFMLVCTLPFRAAYFLmdghWVFGDimCRIMSYTL 124
gi 395521035 142 NFYPGVYLVVFVLGALGNGFSIFIFLQPSKkpksVNVFMLNLAVSDLLFVCTLPFRADYYLrgshWVFGEtaCRIMSYSF 221
gi 149635908  21 AIYPPVYLSIFVLGILGNGFSIFIFLQSFRkqtsMNVFMLNLAISDFLFVFTLPFRADYYLknskWVFGDitCRLMSYSW 100
gi 558184344  18 MAYPTIYISVFILGSFGNGLSIYVFLQPYKkktsVNVFMLNLAISDFLFVWTLPLRATYYLmnssWVFGDlgCRILSYAL 97
gi 557295710  19 VVYPTAYLTIFIFGVVGNGLSIYVFLQPCKrktsGNIFMLNLAISDLMFVSTLPFRAAYYLmksdWIFQDvfCRIVSYIL 98
gi 663257852  22 VIYPNMYLFIFFQGTVGNGLSIYVFFQPSKrktsANIYMXNLAVSDLMFVSTLSFGATYLLlgsdWIFGDiiCRIMIYTL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                        #
gi 20138034  119 YVNMYSSIYFLTVLSVVRFLAMVHPfrLLHVTsiRSAWILCGIIWILIMASSIMLLDsgseqngsvTSCLElnlykiakL 198
gi 483518343 114 YVNMYCSIYFLTVLSVVRFTAIVYPfkRWKVTnmKYAKITCAMIWVFVLAASSPLFCkqiagydkqEKCLDlhpgstdiL 193
gi 557019034 125 YLNMYCSIFFLTALSFLRYLAIVHPckYIKLRtiRSAKIACTVIWIFVVMATSPLLLngtskinekEKCLEittpvmkkI 204
gi 395521035 222 HANMYVSVYFLTVLSIVRFLATVCPfrLLHVTslRTAWSLCAAIWVLVLAPSGLLLSsgtskngkrASCLEmnlskitrL 301
gi 149635908 101 YVNMYSSIYFLTVMSIVRFLAIVHPfrLLSLTsiKGARILCVTIWTFVMVISATLLKggssqknneTSCLDpekekiqrL 180
gi 558184344  98 YVNMYSSIYFLTVLSIVRFVAIVHPfkHWKLTtiKYSRIICGVIWGFVMICASRLLFlka---kdiNKCLDlqegssekI 174
gi 557295710  99 YVNMYCSIYFLTTLSVARFMVIVYPfkCFQVTstKYARIICVVIWIFVMASSSQLLGtgttvtnssTQCLDlqpnnidkI 178
gi 663257852 102 YMNMYXSIYFLSVLSMVCFIAIAYPfkHWKITm-KRGRILCAAIWILVLAASSPLLSkgvtgyrsqAKCLDlhpsrkskL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ### ### ##                                                 #  ## ##  #        
gi 20138034  199 QTMNYIALVVGCLLPFFTLSICYLLIIRVLLKvevpesglrVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLttwkvg- 277
gi 483518343 194 LMLNSVVLVVGFTLPFCTIIICYVFAIRALLKsrtpqrrrtVSHKKALSTIIITLILFLLCFLPYHVLRTVHLmlgsws- 272
gi 557019034 205 VVMNYVVLFVGFIVPFFITSICYICILRTLLKpnvnhsrmrVSYKKATVMVIIIMCIFLICFLPYHILRTIHLemlqpta 284
gi 395521035 302 RILNHVVMVVGFALPFCTLTICYLLMIKSLLRlkvpksnarISHKKALITVTIALILFVLCFLPYHILRTLYLiqwreg- 380
gi 149635908 181 LILNNIVLAVGFILPLGTLSVCYILIIRTLLKprvpesglrPSNKKALLTISIILFFFLVCFLPYHLLRTVHLlawsen- 259
gi 558184344 175 RELNYIVLVVGFILPFCTIIVCYVLVIKALLKprvpqakirAPHKKAVSTIVITLSLFLICFLPYHILRTIYLqewrkdn 254
gi 557295710 179 FLLNNIVLVVGFSLPFCTIVVCYVFVIKALLKsktpntkvrASHKKAKLTIILTLFIFFLCFLPYHILRTVHLvqtkng- 257
gi 663257852 181 LMMNSFILVIGLILPFCILIVCYIFAIKALLRsrtlqhkeaACHKKALPTIIISLILFLICFLPYHGLQTTHLmhgscs- 259
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
Feature 1                    ## ###  #  ##                     
gi 20138034  278 -------lckdrLHKALVITLALAAANACFNPLLYYFAGeNFKDRL 316
gi 483518343 273 -------qnnlaVHKALVVTLCLAAMNSCLDPVLYYFAAeNFKARI 311
gi 557019034 285 tdvatgcdkvnrVHKAVVITLCLAVANSCLDPLLYYFAGeNFKEKL 330
gi 395521035 381 -------rcneqLHKAVIVTMAMAVANSCLNPLLYYFAGeNFKQRL 419
gi 149635908 260 -------kchsrVHKAVVITLCLAAANNCLNPLLYYFSGeNFKERL 298
gi 558184344 255 t----fqgcnflLHKGAVITLCLAAMNSCLDPILYYFAGeNFKERF 296
gi 557295710 258 ------ieskcnLHKGVIITLCLAAMNSCLDPVLFYFVGeNFKARL 297
gi 663257852 260 -------qanlpLHKALVAAFCLAATNSCLDPVFYYFTAeIFNASI 298

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