Conserved Protein Domain Family
7tmA_CysLTR1

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cd15158: 7tmA_CysLTR1 
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320286
View PSSM: cd15158
Aligned: 10 rows
Threshold Bit Score: 480.012
Threshold Setting Gi: 632935521
Created: 18-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##            ###### #
gi 20137910   39 QVYSTMYSVISVVGFFGNSFVLYVLIKTYHeksaFQVYMINLAIADLLCVCTLPLRVVYYVhkgkWLFGDflCRLTTYAL 118
gi 66472452   16 QVYSTVYSIITVFGLMGNGFALYVLLRTYRqtsaFHIYMLNLGVSDLLCVSTLPLRVLYYInkgqWNLGDflCRLSSYAL 95
gi 20138087   24 QVYSTLYSMISVVGFFGNGFVLYVLIKTYHkksaFQVYMINLAVADLLCVCTLPLRVVYYVhkgiWLFGDflCRLSTYAL 103
gi 465996522  27 KVYSTLYSMIAILGFVGNGFVLCVLIKTYQqktaFQIYMLNLAVSDLLCVCTLPLRVVYYVhrgnWFFGDflCRVSSYAF 106
gi 512859629  45 KVYSTAYSMFTLFGLFGNSFALFVLLKTYRqrtaFHIYMINLAVSDLLFICTLPFRIVYYVskgrWYFGNflCRISSYVF 124
gi 632935521  25 QIYSTIYSFIFVVGLSGNSFALYVLVKTFKqrtaFNIYMLNLAISDLLCVCTLPLRVAYYSskgrWIFGSfmCRISSYAF 104
gi 556993060  16 KAYSTVYSLVTVFGFVGNGFALFVLIRTFRqktaFHIYMLNLAISDLLCVCTLPLRVVYYVhkgqWLFGDalCRISTYAF 95
gi 432880439  24 MVYSTFYSVVTVFGLVGNGLALLVLFRTQRqttpFHVYMVNLALSDLLCVMTLPLRVSYYArrgrWEEGDflCRISSYFL 103
gi 657797511  26 RVYTTTYSIITVVGLVGNGLALVVLIKTRSqnspFHIYMMNLAMSDLLFVLTLPMRVLYYVkkgqWDLGDflCRISSYTL 105
gi 410913429  26 QVYSTLYSVITVLGLAGNGLALAALSRPRRqsssFYIYLVNLAVSDLLCVMMLPLRVVYYVkkgqWDYGDvvCRLTSYSL 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 20137910  119 YVNLYCSIFFMTAMSFFRCVAIVFPvQNINLVtqKKARFVCIGIWIFVILTSSPFLMyksy-qdekNNTKCFEPPqnnq- 196
gi 66472452   96 YVNLYCSVFFMMAMSFTRFLAIVFPvQNLRLAteKKAWIVCVCIWIFICMTSSPFLLsgqhtdpltNKTKCFEPPekpg- 174
gi 20138087  104 YVNLYCSIFFMTAMSFFRCIAIVFPvQNINLVtqKKARFVCVGIWIFVILTSSPFLMakpq-kdekNNTKCFEPPqdnq- 181
gi 465996522 107 YVNLYCSILFMTAMSFSRCIAIVFPvQNLNLVteKKSRLACMSIWIFVTLTSSPFLLsgsy--qegNKTKCFEPPkssq- 183
gi 512859629 125 YVNLYCSIFILTAMSITRFLAIVFPvRNLKLVsiKRAKWACAGIWIFVTVTSSPFLMtgsy--tvdNMTKCFEPPpsne- 201
gi 632935521 105 YVNLYCSIYFMTAMSFTRFIAIVFPvQNLKIVniKKAKIVCSVIWIFVMLTSTPFLMkgsh--idgNKTKCFEPPshssk 182
gi 556993060  96 YVNLYCSILFMTAMSLSRFIAIVFPvKNLNLVnvKKAKIVCLGIWIFVTLTTSPFLMtgts--vknNKTKCFEPPdti-- 171
gi 432880439 104 YVNLYCSIYFMTAMSVTRFLAIVYPvQNLQLVtvNKSRIVCVCIWIFCSLSMSSFLMsgqhvdnstNIIKCFEPPgqdsk 183
gi 657797511 106 YVNLYCSIYIMAAMSVTRFMAIVFPvQNMRLVtvKRARLVCVSIWLFISVSSTPFLMsgekfdpvtNKTKCFEPPsstq- 184
gi 410913429 106 YVNLYCSIYLMTAMSISRFLAIVFPmKNMQLVkvKCARRVCVCIWLFVCLSTSPFLMngqhvdtstNKTKCFEPPqgqg- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #  ### ### ##                                                 #  ## ## 
gi 20137910  197 -----akkyVLILHYVSLFFGFIIPFVTIIVCYTMIILTLLKntmk--knmPSRRKAIGMIIVVTAAFLVSFMPYHIQRT 269
gi 66472452  175 -----sldkLIMLNYFSLVVGFIIPFLVILLCYAGILRTLLRntsgankqrYTRNKAIRLIIVVMLAFLISFMPYHIQRT 249
gi 20138087  182 -----tknhVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKksmk--knlSSHKKAIGMIMVVTAAFLVSFMPYHIQRT 254
gi 465996522 184 ------mtsLLVLHYIALFVGFIIPFSVITICYAMIIRTLLKnslk--knqSTRKKAIWMIIIVTAAFLVSFTPYHIQRT 255
gi 512859629 202 -----akimVIVLNYISLVFGFIIPFAIILVCYTMIIKTLLKnsmk--kqqESRKKAIRMIIIVMAVFFLSFMPYHIQRT 274
gi 632935521 183 kavskglktLLTLNYISLILGFIIPFLIIIICYAFIVKSLLKstaainkkkASRRKAIHLIIIVLTAFLVSFMPYHIQRT 262
gi 556993060 172 ------kpqLLALNYISLVVGCIIPFCVILLCYTLIIRALLNnqmk--nksSSHKKAIRLIIIVMTAFFVCFLPYHIQRT 243
gi 432880439 184 -----qltkLLLLNYIGLVFGFLLPFLIIGICYVGIVRTLLSrtqtarrqqASGVRAIRMIVIVLLTFLFSFTPYHIQRT 258
gi 657797511 185 -----qlqkLKKMNYFALVVGFVVPFLVILICYVGIVRVLVSrnnvarrqsETGSKAIRMIVIVLLTFLICFMPYHIQRT 259
gi 410913429 185 ------lhkLLVLNYLSLVLGFALPFLVILLCYAAIIWTLLSrkytvrqqqGIGTKAIRMIVVILLTFFICFMPYHVQRT 258
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
Feature 1         #                ## ###  #  ##                     
gi 20137910  270 IHLHllhsetrpcdsvlrMQKSVVITLSLAASNCCFDPLLYFFSGgNFRRRL 321
gi 66472452  250 LHLHfksrksatceevnyMQKSVVITLCLAAANSCFDPMLYFFSGeNFRHRL 301
gi 20138087  255 IHLHflhnetkpcdsvlrMQKSVVITLSLAASNCCFDPLLYFFSGgNFRKRL 306
gi 465996522 256 IHLHflkrkdsscedilfMQKLVVITLSLAASNCCFDPLLYFFSGgNFRRRL 307
gi 512859629 275 IHLHflkgnkn-ckeslhMQKTVVITLALAASNCCFDPLLYFFSGeNFRRRL 325
gi 632935521 263 VHLHslfqagencdeiiyMQKSVVVTLCLATANTCFDPLLYFFSGeNFRRRL 314
gi 556993060 244 IHIHflmqkns-cedrlnMQKSVVITLCLAASNTCIDPLLYFFSGeNFRRRL 294
gi 432880439 259 VHLHslsrensscseqiaIQKSVVVTLCLAAANSCFDPLLYFFSGeGFRSRL 310
gi 657797511 260 VHLYlitpydt-csyqrgMQKSVVVTLSLAAANTCFDPLLYFFSGeSFRKRV 310
gi 410913429 259 VHLSflsrvdttcaerttMQKSVVVTLTLAAANSCLDPLLYFFSSkSFRTCS 310

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