Conserved Protein Domain Family
7tmA_Proton-sensing_R

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cd15160: 7tmA_Proton-sensing_R 
proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).
Statistics
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PSSM-Id: 320288
View PSSM: cd15160
Aligned: 7 rows
Threshold Bit Score: 350.532
Threshold Setting Gi: 37537754
Created: 18-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##            ###### #
gi 37537957   15 YLFPIVYIFVIIVSIPANIGSLCVSFLQAKkesELGIYLFSLSLSDLLYALTLPLWIDYTWnkdnWTFSpalCKGSAFLM 94
gi 47834444   32 TLAPVVYVTVLVVGFPANCLSLYFGYLQIKarnELGVYLCNLTVADLFYICSLPFWLQYVLqhdnWSHGdlsCQVCGILL 111
gi 1708027    18 LFPPSLYIFVIGVGLPTNCLALWAAYRQVQqrnELGVYLMNLSIADLLYICTLPLWVDYFLhhdnWIHGpgsCKLFGFIF 97
gi 148229955  16 TLFPVIYGLVFVFGLIGNLAAIGVIVQHVKrgnVLGIYLANLCASDLMYISTLPVWIAYTAke-dWLFGplsCKIVGFFF 94
gi 37537754   43 IVLVVVYSAVCTLGVPANCLTAWLALLQVLqgnVLAVYLLCLALCELLYTGTLPLWVIYIRnqhrWTLGllaCKVTAYIF 122
gi 159155397  30 IFLPVLYGIFFVIGTPLNLLALFGLYKLIQsenVLPVYVINLLISDLIQLLTLPLWMDYYAnghnWRFGprsCQFMGLFF 109
gi 465952246  14 YFLIPVYSVVVGAGLPLNCLALWTLVSQINksiVLSVYMLNLVVADLLQTLTLPFWIYYSYwdhnWDLGagaCVAVSLGF 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 37537957   95 YMNFYSSTAFLTCIAVDRYLAVVYPlkFFFLRtrRFALMVSLSIWILETIFNAVMLWedetvveycdaeksnfTLCYDky 174
gi 47834444  112 YENIYISVGFLCCISVDRYLAVAHPfrFHQFRtlKAAVGVSVVIWAKELLTSIYFLMheevie-----denqhRVCFEhy 186
gi 1708027    98 YTNIYISIAFLCCISVDRYLAVAHPlrFARLRrvKTAVAVSSVVWATELGANSAPLFhdelfr-----drynhTFCFEkf 172
gi 148229955  95 NANLYTTIYFLSCIAMDRFVATVFPfqARSLRtmKSALIICACVWLIILGTHSIFLGrdelfr-----ssqnvQLCYEky 169
gi 37537754  123 FCNIYVSILFLCCISCDRFVAVVYAleSRGRRrrRTAILISACIFILVGIVHYPVFQte------------dkETCFDml 190
gi 159155397 110 YISIYAGIFFMCIIALERHLAIARPlsFKHLRnlRFARWIAISIWVLIAVPPAIAFDklfpk-------qenyTLCIEky 182
gi 465952246  94 ITNFYAKNGFLCLIAMERYIGVVHPlwFRGLQtiHGATKVSATAWVLVLGICSVGTGllrk--------epeaGRCYEgy 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  ### ### ##                                              #  ## ##  #     
gi 37537957  175 plekwQINLNLFRTCTGYAIPLVTILICNRKVYQAvrhnkatenKEKKRIIKLLVSITVTFVLCFTPFHVMLLIRcileh 254
gi 47834444  187 piqawQRAINYYRFLVGFLFPICLLLASYQGILRAvrrshgtqkSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRsvwea 266
gi 1708027   173 pmegwVAWMNLYRVFVGFLFPWALMLLSYRGILRAvrgsvsterQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRsaiyl 252
gi 148229955 170 pmdqwMARINYFRIFVVFLIPLVLLIVFYCSVVRVvhrstslekEQKQKIIGLLMTMMAIFIICYLPYHVVLFIRsyisd 249
gi 37537754  191 qmdsrIAGYYYARFTVGFAIPLSIIAFTNHRIFRSikqsmglsaAQKAKVKHSAIAVVVIFLVCFAPYHLVLLVKaaafs 270
gi 159155397 183 psegsFITYRLITLLVSFIIPLSFIVGLHRKTVRSlmainsllsEEKRSIRGLLTLLVAVFVTVLGPYHFIGCVKyvgll 262
gi 465952246 166 plgtyYASFKMATMALSFFLPCFFMGFFYLRVLHKlrqlpslerETKRQIYSFISLIIISFFLLCVPYQVTSFYKyqrem 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
Feature 1                       ## ###  #  ##                     
gi 37537957  255 avnf--edhsnsgkrTYTMYRITVALTSLNCVADPILYCFVTetGRYDM 301
gi 47834444  267 s--------cdfakgVFNAYHFSLLLTSFNCVADPVLYCFVSetTHRDL 307
gi 1708027   253 grp----wdcgfeerVFSAYHSSLAFTSLNCVADPILYCLVNegARSDV 297
gi 148229955 250 knm----ctcsleekVRPAYRISFSLTSLSSALDPFINIFISdsIRQDL 294
gi 37537754  271 yyrgdrnamcgleerLYTASVVFLCLSTVNGVADPIIYVLATdhSRQEV 319
gi 159155397 263 ihs----rkcvwekaVFVPYQLGRGLLSLNSLLDPVFYIFLRrdFRAAA 307
gi 465952246 246 vqnn--eglclfetnLFIYSQAALCLTTLGNVLDPLLYILLLkdVRTEL 292

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