Conserved Protein Domain Family
7tmA_GPR20

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cd15163: 7tmA_GPR20 
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors
Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.
Statistics
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PSSM-Id: 320291
View PSSM: cd15163
Aligned: 6 rows
Threshold Bit Score: 401.478
Threshold Setting Gi: 449284303
Created: 18-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##         ###### ##  
gi 281185467  54 LALMAVHGAIFLAGLVLNGLALYVFCCRTRAKtpSVIYTINLVVTDLLVGLSLPTRFAVYYgarGCLRCAFPHVLGYFLN 133
gi 449284303  21 VALMVVNTIIFLVGVVLNSLALYVFCFRTKTKttSVIYTINLIVTDLLVGFSLPVRIIMFYsagDCLNCSLVHIFGYFVN 100
gi 557022376  28 IALMVINAIIFLVGIMLNSLALYVFCFRTKTKttSVIFTINLVITDMLVGFSLPTRIIIYYsggNCLTCSFVHIFSYFVN 107
gi 688591669  48 IALVVINTLIFMVGMTLNSLALYVFCYRTKPKttSVIYTINLVVTDLLVNLSLPTRIVLYYsggKCLSCSYMHIFSYFVN 127
gi 632940061  52 LALMIINLLMFVVGVVLNSIALYVFCFRTKTKttSVIYTINLAITDLMVGFSLPTRIVMYYsggNCLTCSFVHIFSYFVN 131
gi 301609946  51 LALMVINILIFLVGIVLNSLAIYVFCFRTKTKttSVIYTINLVVTDLLVGLSLPTRIVMYYsagNCKYCYFVHSFTYFVN 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                            # #####          #  ### ### ##     
gi 281185467 134 MHCSILFLTCICVDRYLAIVRPegSRRCRqpACARAVCAFVWLAAGAVTLSVLG---VTGSRPCCRVFALTVLEFLLPLL 210
gi 449284303 101 MYCSILFLTCICVDRYLAIVQVeaSRKWRnpTCAKGICVFIWIFATVVTFSILTtaiQFATCCLSKILVLMVCEYFFPLI 180
gi 557022376 108 MYCSILFLTCICIDRYLAIVQVeaSRRWRnpNYAKGICIFIWFFAMVVTFSVLTtaiKYSACCLPRLLVLTVFEFFLPML 187
gi 688591669 128 MYCSILFLTSICVDRYLAIVQSeaSRKWRnpNIAKAVCVCIWLFAIVVTYSLLTt--AFKQSGLSKLFALTIFEFFLPMV 205
gi 632940061 132 MYCSILFLTCICVDRYLAIVQVeaSRKWRnpHYAKGISVFIWLFAIVVTYSILTtaiKYASCCLSKFFALTMFEYFLPLV 211
gi 301609946 131 MYCSILFLTCICVDRFMAIVQVeaSRRWRnpNYAKLICICIWIFAIVVTFTILTttiNHPSCCLFQLFSLTAFEYFVPLI 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   #  ## ##  #          ## ###  #  ##   
gi 281185467 211 VISVFTGRIMCALSRPgllHQGRQRRVRAMQLLLTVLIIFLVCFTPFHARQVAValwpdMPHHTSLVVYHVAVTLSSLNS 290
gi 449284303 181 IIIFFTTRIMCALSKPslmHQSRERRMRAVQLLITVLIIFMICFTPFHVRQVAIainpdMPHDVSLLVYHVTVTLSSLNS 260
gi 557022376 188 IITFFTIRIMWALSNSslmQQSRERRMRAVQLLITVLVIFMICFTPFHIRQVVTffhpdIPHKTSLIVYHVTVTLSSLNS 267
gi 688591669 206 IIVAFTIRIVCALSSPglmQQSRDRRMKAMQLLSTVLVIFTICFTPFHVRQVLFyf--hPDLPHHVIVYHVTVTLSSLNS 283
gi 632940061 212 VITVFTIRIMCALAKPnlmHQSRERRMRAVQLLLTVLLIFMICFTPFHVRQVMSyvkpdIPRHISLIVYHVTVTLSSLNS 291
gi 301609946 211 IITFYTLRIMWALSRStlmNQSRERRMKAVQLLITVLIIFTVCFTPFHVSQVILcinssISLDVNIVVYHVTVTLSSLNS 290
                        250
                 ....*....|....*...
Feature 1                          
gi 281185467 291 CMDPIVYCFVTsgFQATV 308
gi 449284303 261 CMDPIVYCFVTnnFQSTM 278
gi 557022376 268 CMDPIVYCFVTnnFQSTM 285
gi 688591669 284 CLDPVVYCFVTsnFQSTM 301
gi 632940061 292 CLDPVVYCFVTnnFQSTM 309
gi 301609946 291 CMDPIVYCFVTnnFQSTM 308

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