Conserved Protein Domain Family
7tmA_GPR35-like

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cd15164: 7tmA_GPR35-like 
G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.
Statistics
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PSSM-Id: 320292
View PSSM: cd15164
Aligned: 18 rows
Threshold Bit Score: 354.26
Threshold Setting Gi: 432107243
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 68068087   21 LGFYAYLGVLLVLGLLLNSLALWVFCCRMQqw-tETRIYMTNLAVADLCLLCTLPFVLHSLRdts---dtpLCQLSQGIY 96
gi 126314305  18 YVYMSLYGVIFIVGLTFNVLALWVFCCRMRkw-tETQVYMVNLAVADGCLILVLPIVIYFTKmscs--edlSCQVPQGIY 94
gi 149574640  15 TSEIIYISLLLIFGILLNAVALWVFCYKMKrw-tETGVYMANLAMADLCLLFALPFVIWTLKmkds-qdtlLCRISQSIY 92
gi 126314303  16 TISTLYLVILLVLGTALNVLALWVFCCRMRrw-tEMRVYMANLAGADCCLLLSLPVVLYTMNrdhw-egsfLCTVSQSIY 93
gi 432107243  57 AMTIASICLILVLGLLLNSLALWVFCCRMRrw-tETRIYMVNLVVADCLLLLSLPGILHTLGqgvgaqegpLCRVLQGFY 135
gi 301607616  42 MFQLIILSLTLFFGTLFNSFAIWVFCCKMKkw-tETRVFMMSLLFSDCCLLLTIPFRIYATQhrwd-lpreLCTTLAYAY 119
gi 395537119 118 KMQTVYMIILLILGIMFNSLALWVFCCRMRkkwtETVIYMTNLAVADLCLLCALPIMLYSQKhike-kdtvLCQVSQSIY 196
gi 641803475  17 LIQVIIYATIFPFGATFNVLALWVFCCKLKkw-tETRVYMINLVITDCSVVCSLPFQMYFFWndwh--rdtLCLTIQSIY 93
gi 345315364  21 ITTYVCITIVFSVGLVFNVFALWVFCYKMKkw-tETRIFVINLAAADLCLIFSGPILLYSMKesnqqednaWCRTSQSIY 99
gi 557291148  21 LIPLFFHIPIFIFGAIFNALALWVFCCKLVkr-tETKIYMINLVIADCSLVCVLPFLIYFHQknwp--rdeACLAVEIMY 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                     #  #
gi 68068087   97 LTNRYMSISLVTAIAVDRYVAVRHPlrARGLRSPRQAAAVCAVLWVLVIGSLVARWLlgi---qegGFCFRst--rHNFN 171
gi 126314305  95 LVNVYMSISIPTAIGVDRYVAIKYPlkAKALRTPGRAAIVCVLLWVVVITMMAFRVIwqi---hdgAFCFHkt-teIHTS 170
gi 149574640  93 LMNRHMSIYTVTLIALDRYISVKYPlkSRILRSPKKAALACALLWIFVISLVSILYTvpf---qegNFCFGsk--aRNPN 167
gi 126314303  94 LINGYMSISIITAIAMDRYAAIQYPlrARKWRSPQQAAGTCAVLWLLVICVVSLPAAwkq---dgkSFCFGks-qtRSFW 169
gi 432107243 136 YVNTYMSMWLLTAIATDRYAALHFPlrARAWRGPRQAALTCAALWLLVIGAVALPVAwlr---pgeSFCFGrg-htRGPK 211
gi 301607616 120 FMNTYLSIAIITLISVDRYIAIKFPlrSRSLRSPKKAALACAIVFALLLCTRIFILLtaeksvpspGFCFRkiltrPLKR 199
gi 395537119 197 LMNRYMSISIITIIAVDRYVAIRFPmqAKRLRSPGRSVGICALLWVLVLIFTVTSGAkei---qegNFCFHne-krKPSN 272
gi 641803475  94 LINMSMSIYIITVISVDRYIAIKYPlkAKSLRSPWKAALICGLLWVSTIIGLNIKQRre------eTLCLQkvstkPSTS 167
gi 345315364 100 LINKQMSIYIVTLIAVDRYFAIKYPlkAKIFRSPLKAAITCGVFWILVIVSVILLLIsskl--yksNFCFGkr-rmRDIR 176
gi 557291148  98 MVNMLMSIYIITAITVDRYIAIKHPlkAKSLRSPLKAAVTCGLLWLLVIISLYLRRRsv-----neSICLQkistrPTIF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ## ### ##                                                  #  ## ##  #          
gi 68068087  172 SMAFPLLGFYLPLAVVVFCSLKVVTALaqrppt-dvgqaEATRKAARMVWANLLVFVVCFLPLHVGLTVRlavgwna--c 248
gi 126314305 171 MVLFSLLGVFLPLVILVFCTLQIVCTLlkvqrr-disevRQIRKSVAMVCANLVVFVVCFLPLHISIVLNfflg------ 243
gi 149574640 168 IIVFSLLGFFISLVILTFCSSQVIMSLikkkkt-dpyeeQLIKKAVYMVSANLIVFVICFLPLHIALLIRyvielks--c 244
gi 126314303 170 AIVSSLVLFFIPFVILVFCSVRVLRNLvrkkaqeptqgrRLFRKAYHVVLANLIIFMVCFLPQHVALLAKlvaeymeasc 249
gi 432107243 212 ALIFSLLLFFLPLLILSFCSCQVLRRLhrewtraqpqatTPILKALCVVMANLATFVLCFLPLHVALLAKlvaqwmnaac 291
gi 301607616 200 NLYFTVTGFYIPLPIIIFCTTEVIRFLkmkdkt-svyehECIKKSIKIMSANLIIFLVCFLPLHILNIIRfameslkldc 278
gi 395537119 273 PAISSVLGFYIPMSILVFCSIQVIVNLvrkkkt-dahekKVIQKVIWIITANLLVFLACFLPLYVTLSVRyvlqmet--c 349
gi 641803475 168 VLFFLIFFFLIPLIILSFCSMHIIRSLkkrmit-nphenKLIEKAIYIVSANMIVFILCFSPVQIGMLARfvmekngvnc 246
gi 345315364 177 LRVFSLLIFFIPLLILTFCSIQVISSLikkkkm-eareeTLIQKAVYIVSANLIIFLICFLPQHILLLVQlwdkqnv--f 253
gi 557291148 173 LPFLFVFGFLIPLIILSSCSIQIIKTLrkriht-nphekKIFQKSIYVVSANMTVFIVCFSPFCIGEFARfvmengtvsc 251
                        250       260       270
                 ....*....|....*....|....*....|....*....
Feature 1             ## ###  #  ##                     
gi 68068087  249 alletIRRALYITSKLSDANCCLDAICYYYMAkEFQEAS 287
gi 126314305 244 -qndrFKKVFKVVTLLSNTNCCLDAICYYFVAkEFQQVN 281
gi 149574640 245 salerILMFILISSRLSNANCCLDAICYYFVAkEFQQAS 283
gi 126314303 250 piiqhVITSVRVASRLANANCCLDALGYYYVVqEFQEEV 288
gi 432107243 292 ptiqrVATFVQVASRIANANCCLDAVCYYFVAtEFQEEV 330
gi 301607616 279 tliklINDYVYAAQVIGDLNCCLDSVCYYFVAkEFWEST 317
gi 395537119 350 sskriWRNAIFITSQLANANCCLDAICYYFVAkEFQEAS 388
gi 641803475 247 laiqkIRIFINVAACIANSNCCMDAICYYFVAkEFQEAS 285
gi 345315364 254 lersnLGILLTTSYQLAYINCCLDAVGYYFVAkEFQEAS 292
gi 557291148 252 faiqnVRNFNYIAMCIANSNCCLDTFCYYFVAkEFQEAF 290

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