Conserved Protein Domain Family
7tmA_FFAR2_FFAR3

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cd15170: 7tmA_FFAR2_FFAR3 
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.
Statistics
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PSSM-Id: 320298
View PSSM: cd15170
Aligned: 18 rows
Threshold Bit Score: 326.524
Threshold Setting Gi: 388255265
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##            ######
gi 3122160     8 SLILMAYIIIFLTGLPANLLALRAFVGRIRqpqpaPVHILLLSLTLADLLLLLLLPFKIIEAAsnFRWYLPkvVCALTSF 87
gi 161611891   8 EAFLTIYIITFLIGFPGTVLALCSCIRKIAsk-piPIDLFMLNLAISDLIFLSFLPFKMKEAAdqMIWNMPqiLCQLSLF 86
gi 597789955   9 IMFLSTYIVTFLIGFPANAVAFFIFVRKIFrk-piPIDIFLLNLTVSDLIFLSFLPIKMKEAAdrMIWNMPyiLCQLNIF 87
gi 292622744   5 WVIFAVYVLTFLIGLPANLLAICTFIKKLGdk-psPNDILLFHLTTSDLVFLLFLPFKMYEAFmgMKWHLPqtLCSIASF 83
gi 602670260   9 NTYISVYLLTILIGFPTNLLALCALIQKIRnk-atPNSVLLLNLTISDLCFLVFLLFKIAEQIa-GRWVFPtfLCPFTGL 86
gi 573908006   4 YPVLAVYIVTFLTGLPCNLLALAAFIVKVRrk-plPTDILLLNLTVSDLIFLFFLPFKISEAFy-GHWVLPrlLCSVSSF 81
gi 657788723   6 NIILAVYIISFLIGLPANLLALYAFSVKICsk-pqPTDILLLNLTVSDLLFLFVLPMKMHEAAsgMIWTFPavLCSITSF 84
gi 130485058   7 QLLLSFYILTFLIGLPANILAFITFCRKVHrk-ptPIDILLLNLTISDLIFLAVLPFKMKEAVdqMIWRLPfyLCSISSF 85
gi 512857571  10 WLFLIVYIITFVAGLPLNLLAFVTLIRKFRqq-lvSIDILLFNLTVSDLLLLAFLPFRIVEAAsgMDWFMPyvFCPLSFF 88
gi 465952212   8 QLSLAVYTVTFVTGLPLNLLAFCAFVVKARrr-llPADVLLLNLTVSDLVLLAFLPIRITEASweMKWKMPdfLCPLSGL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                            # #####                       
gi 3122160    88 GFYSSIYCSTWLLAGISIERYLGVAFPvqYKLSRRpLYGVIAALVAWVMSFGHCTIVIIvqylntte------------- 154
gi 161611891  87 MFFLPFYSSVLFLTAISIERYVCVAFPtkYKNPKRiIYTIITCVAIWVTVVGYSILPYKvtftdshvadnttkvsftdsl 166
gi 597789955  88 LFFLPIYSSILFLTAISAERFVCVAFPvlYKARRRiIYCLAVSVSFWVLAVSNASVAYWagynnfsendn---------- 157
gi 292622744  84 FFFTTIYTSSLLLMAIAVDRYLGLAFPfkYRMLRKpIYATVGCVFIWLVSAAHCSIVFIivhmpd--------------- 148
gi 602670260  87 VYFSTIYSSTLFLTAVSVERYLGVAYPihYKLRRHsTYALIASLGLWICSFGHCSIVYVtefkrdny------------- 153
gi 573908006  82 VFFSTIYITTLILTAVSVDRYLGVAFPimYKYKRQpVHAIVVSVIFWVFSSAHCSIVYItellyp--------------- 146
gi 657788723  85 IYFSTIYSSSLLLMAISVIRYVGVAFPifYLRVRRpLYAVVASAVIWLLSMGHCSITIIienhpyfm------------- 151
gi 130485058  86 LFFSTIYTSTLFLTAISIERYLGVAFPirYALGRRpRNAVIACCFLWLLGSLNLSIVYIvpyidssdnst---------- 155
gi 512857571  89 MYFSSIYITSLFLMAISVERYLAVAYPikYKLLKNpVYSVLGSVVIWILGTMHCSVVYIvehfipa-------------- 154
gi 465952212  87 LFFSSIYLTTLSLTGVSVDRYLSMAFPlrYKTGRRpAYAVAAVALFWVAAFSHCSVIYVvqyqakg-------------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     #  ### ### ##                                      
gi 3122160   155 --------qvrsgneITCYENFTDNQldvVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMlsqplvgaQRRRRAVGLAVV 226
gi 161611891 167 vadnttnqrtlvaepQRCYSKFTKEQlkeLLPIRLSIAVLFFFLPLLICCFFYVSFIRILtnlhlikrQRKLRAIGLVVG 246
gi 597789955 158 ----isekltpvmegQQCYANFTKEQlkvLLPVRLHIVLVFFCIPFVVCWFCYINFIRILsklphigrRRKLRAIGLALG 233
gi 292622744 149 ----------qntngSVCYEEFTEEQkriLLPVRLEFFVVIYTLPLLVCVFCYINCINILysrphivkVKKQRAIGMALC 218
gi 602670260 154 -------sipnepstDICYDNFTEAQletLLPVRLELSIVLFLVPSLITCFCYFGFMRIVissphihrSKKQRAVGLVAA 226
gi 573908006 147 ---------rdttmePVCYDNFTDKQlavLLPVRLELCIVLFLIPLIISTFCYLNFIRILntlpnispQKKLRAIGMALG 217
gi 657788723 152 -------enssqnnsSRCYDNFQENQlkvLLPVRLEMFLLLCLFCIYCYLHTIWILSHRTsi----sqARRRKAIGMALG 220
gi 130485058 156 -----ysklqlnphvRNCYDNFTLEQmtiLLPVRLELFLLLFCIPLLICCFCYINFIRILsnlphlgrRRRLRAIGLAVG 230
gi 512857571 155 --------nmnktnvTRCYDQFSPEQlkiLLPVRLEMFVVLFCIPLLVTVFCYFNFVKILvaqpriqkEKKKRAIGLVVA 226
gi 465952212 153 --------ndtvgnlTRCYATFTDHQlavLLPVRLEMFLVLFCLPLGITAFCYARFIAIIrslplvspGRKRRAIGLVAA 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #  ## ##  #     ## ###  #  ##                       
gi 3122160   227 TLLNFLVCFGPYNVSHLVGYhqrkSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGR 286
gi 161611891 247 TLLVFTTCFAPYNVSHLVGFikkeSPAWRMKTLMLSTLNVCYDQIIFFCISREMRKAIKV 306
gi 597789955 234 TLLVFCVCFAPYNASHVVGYikreNPPWRMKAVMLSTLNASLDPVIFYCTSWEVRKIVKR 293
gi 292622744 219 TLTIFLLCFLPYNLSHLVGYssnkSPPWRYYTLLPSTLNTCLDPFVFYFSSSTFRESKTV 278
gi 602670260 227 TLAVFIICFTPYNISHVVGFiewrSPDWRSKALLPSTFNASLDPIIFYFSSSAVQRSCWN 286
gi 573908006 218 TLLIFILCFLPYNISHIVGYvnqkSPEWRTTVLLLSTFNACLDPIIFFFSSSSFQETSKE 277
gi 657788723 221 TLAVFLVCVIPYNLSHLVGYvqrqSPIWRYYVLLLTSLNTCIDPIIFYFSSSAFRCTSAR 280
gi 130485058 231 TLLVFTICFSPYNISHVVGFihrnSEGWRHFALLFSTLNACLDPIIFYFSSAAVRSAIKA 290
gi 512857571 227 TLINFILCFMPYNVSHVVGYmegeSPLWRTYVLLLSTFNSTVDPVIFYFSSASFKKMFLE 286
gi 465952212 225 TFLHFLVCFTPFNISHVVGFvenkSPEWRVYVLLLSTFNASFDPIIFYFSSSSFQKICLE 284

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