Conserved Protein Domain Family
7tmA_CCRL2

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cd15171: 7tmA_CCRL2 
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).
Statistics
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PSSM-Id: 320299
View PSSM: cd15171
Aligned: 5 rows
Threshold Bit Score: 396.893
Threshold Setting Gi: 351695735
Created: 9-Dec-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##          ###### ## 
gi 108885280  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKrvENIYLLNLAVSNLCFLLTLPFWAHAGgd------pmCKILIGLYFV 112
gi 108885281  38 QQVLQFCCAVFAVGLLDNVLAVFILVKYKGLKnlGNIYFLNLALSNLCFLLPLPFWAHTAahgespgngtCKVLVGLHSS 117
gi 431905107  40 QLVPPLYLAVFLVGLLGNGLVVLDLVKFKELKrvENIYFLNLAVANVCFLLTLPFWVHSAlhgglladptCKILAALSSV 119
gi 432108644  41 QLLPQLYTAVSLLGLLDNVLVVFILLKCQRLRhvEHIYLLNLAVSNLCFSLTLPFWAHAAshggtlghptCTVLVALSSV 120
gi 351695735  39 QQAAQLCSALFMVGLLANGWLLFILIKYKGLRhvENIYFLNVALSNLCFLLPLPFWAAAAwpr-----svCGVLLALQSF 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                              # #####              #####      
gi 108885280 113 GLYSETFFNCLLTVQRYLVFLHkgnfFSARRr-vPCGIITSVLAWVTAILATLPEFVVYkpqmedQKYKCAFSRtpFLPA 191
gi 108885281 118 GLYSEVFSNILLLVQGYRVFSQgrlaSIFTTv--SCGIVACILAWAMATALSLPESVFYeprmerQKHKCAFGKphFLPI 195
gi 431905107 120 GLHGEALFSVLLTVFFHKRSFS----SSARKv--PCATVTSVVTWAAAVLVALPEFLFYqpqtgsQEPECFFSElhFLPG 193
gi 432108644 121 GLHSEALFNALLTLQSSLMCFHarslSPAARrrrACGFLASGLAWLVAALLALPEVLQCmaqedsQGDRCPCSRpyFLPG 200
gi 351695735 114 GLHGEALFTVLLTVHASRVRGL----SSALRt-aTWGVIMALLAWLTAFLVTLPELVFYkpprdeQSSLCSISSphFLPA 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  ### ### ##                                         #  ## ##  #          
gi 108885280 192 DETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTlrfrEQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFkehfslsd 271
gi 108885281 196 EAPLWKYVLTSKMIILVLAFPLLVFIICCRQLRRRqsfrERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFqehlslqd 275
gi 431905107 194 DETFWKYFLTLRMNIVGLLVPLSVFIVCYVRMRKTprsrGTNRDLLKLVFAIPFVFLLMWGPYATALFLSTFkdyfplrg 273
gi 432108644 201 QGTAWQPFLTLKVNVAGLLVPLLVFIICLVRLGKT----LRKSDLSQLVFAIMVVFLLMWGPYNVALFLSAFkdffslrd 276
gi 351695735 189 EETSWKRVLTLKMNAVVLVFPLLVLLGGCLGKRSG----EEQRERSGLVRAVAVVFLLMWLPYNIVLFLSAFkecfslrg 264
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
Feature 1              ## ###  #  ##                      
gi 108885280 272 ckssynLDKSVHITKLIATTHCCINPLLYAFLDg-tFSKYL 311
gi 108885281 276 ekssyhLDASVQVTQLVATTHCCVNPLLYLLLDrkaFMRYL 316
gi 431905107 274 ckggyaLDRSVQVTRIIATTHCCVNALLYVLLDq-aFWRRL 313
gi 432108644 277 cgsryhLDRSVQVTAIIASTHCCVNPLLYALLDk-aCRRCL 316
gi 351695735 265 cqsdsrLDAGARVAKVIGTAHCWVNPPLYALLDp-pLRSRL 304

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