Conserved Protein Domain Family
7tmA_CXCR6

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cd15173: 7tmA_CXCR6 
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.
Statistics
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PSSM-Id: 320301
View PSSM: cd15173
Aligned: 5 rows
Threshold Bit Score: 376.419
Threshold Setting Gi: 632965697
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative chemokine binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of chemokine receptors with bound ligands (chemokines, peptides, or chemical antagonists/agonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                                #  #               #  ## 
gi 3121816    32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKlqsLTDVFLVNLPLADLVFVCTLPFWAYAGiheWVFGqvMCKSLLGIYTI 111
gi 163915588  47 YILPVLYSVTCVTGLVGNLLIIIIYAFYEKmrtLTDTFMVNLAMADIFFLCTLPFLAYQVaqgWIFGevMCKITRVVYRI 126
gi 591379692  30 IFLPCMYAFAFAFGLIGNSLILIIYIFCEKlktLTDVFLVSLATADLLFLSTLPFWAYSAareWIFGslMCKIIRGLYTL 109
gi 557004547  34 YFLPWAYSIIFITGLLGNCLVIFTYIYHMKlrtLTDIYLVNLSVADVLFVSTLPFWAYSAaheWVFGrlMCKLTNGLYTI 113
gi 632965697  38 FFIPLFYSIMCVTGLLGNSLVIVIYVFYEKlktVTNIYMVNLAVADLLFLCTLPFWAVNAchgWIFDtfMCKVMNGAYTV 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             ######     
gi 3121816   112 NFYTSMLILTCITVDRFIVVVKatKAYNQQAKrmTWGKVTSLLIWVISLLVSLPQIIYgnvfn-ldklICGYHDEa---- 186
gi 163915588 127 NLYCSMLLLTCITFDRFISITQakKFNMYHSKkhSLGKLVCMIVWLVSLLLAVPQFKYsvt----sneNCFEVYDpp--- 199
gi 591379692 110 NLYTSMLTLTCITIDRFIAIAQatKAHMCQAKrmVWGKVICILVWVISLAFATPQFKYstqsn-ydksVCHAVYPsd--- 185
gi 557004547 114 NLYSCMLTLVCICVDRYIAIAQatKSHTFHNKklLFGKLTCFGVWVFAIILSIPELMFskvln-lsskYCRMSFPpdtki 192
gi 632965697 118 NFYSCMLILTCVSINRYNVIVQatKMLNCKYR--RCHSVVCTAVWLLAIILSLPQFIFseartdssskICSMVYPtnlsv 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #  ##                                                      #      #  #        
gi 3121816   187 -iSTVVLATQMTLGFFLPLLTMIVCYSVIIKTLlhaggFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHwey----- 260
gi 163915588 200 hlEVMVNSFQITVGVFLPLAAMIFCYTFIIKKLifasnYQKHKSIKIIFMVVMAFIATQLPYNIGILCHVVY-------- 271
gi 591379692 186 ltELVFKVLQMTLGFFIPMLTMIICYSIIIKTLlrarsFQKHKSLKIIFSIVVTFILTQLPYNLLILIRNIHvef----- 260
gi 557004547 193 eiEKITIFSQLTVGFLFPFLAMVICYSVIIKTLlnakgVQRHKSLRIIFVVVAIFIILQLPYNIMKLKKMAGhhdae--n 270
gi 632965697 196 aiKVQVNIIQMTVGFLIPFAAMVICYSIIAKTLlhgkgFQKHKSLRIIFVIVIVFVFCQLPFNIVKLMETLSiinnvsik 275
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
Feature 1           #   #  ##  #                         
gi 3121816   261 -yaMTSFHYTIMVTEAIAYLRACLNPVLYAFVSlKFRKNF 299
gi 163915588 272 ---KTFDKTFMLITEAIAYMHACLNPILYFFVGvKFRKNF 308
gi 591379692 261 -nlDYNFDSAVVITEAIAYLHGCLNPVLYFFIGvKFRKNF 299
gi 557004547 271 cdtQVNFKYADLIAEAIAYSHCCFNPFLYAFIGeKFRKHF 310
gi 632965697 276 ctdSIKVDYAIIVTKCIAYVHCCLNPILYVFFGvKFKKYI 315

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