Conserved Protein Domain Family
7tmA_CCR1

?
cd15183: 7tmA_CCR1 
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.
Statistics
?
PSSM-Id: 320311
View PSSM: cd15183
Aligned: 3 rows
Threshold Bit Score: 461.648
Threshold Setting Gi: 341940323
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative chemokine binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of chemokine receptors with bound ligands (chemokines, peptides, or chemical antagonists/agonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                                #  #                #  ##
gi 416802     35 QLLPPLYSLVFVIGLVGNILVVLVLVQYKRlknmTSIYLLNLAISDLLFLFTLPFWIDYKlkdDWVFGdaMCKILSGFYY 114
gi 341940331  35 GLLPPLYSLVFIIGVVGNVLVILVLMQHRRlqsmTSIYLFNLAVSDLVFLFTLPFWIDYKlkdDWIFGdaMCKLLSGFYY 114
gi 341940323  36 TVLTPLYSLVFIIGVIGHVLVVLVLIQHKRlrnmTSIYLFNLAISDLVFLSTLPFWVDYImkgDWIFGnaMCKFVSGFYY 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                            ######      
gi 416802    115 TGLYSEIFFIILLTIDRYLAIVHavfALRARtvTFGVITSIIIWALAILASMPGLYFsktqweFTHHTCSLHFPheslre 194
gi 341940331 115 LGLYSEIFFIILLTIDRYLAIVHavfALRARtvTFGIITSIITWALAILASMPALYFfkaqweFTHRTCSPHFPykslkq 194
gi 341940323 116 LGLYSDMFFITLLTIDRYLAVVHvvfALRARtvTFGIISSIITWVLAALVSIPCLYVfksqmeFTYHTCRAILPrkslir 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ##                                                      #      #  #         
gi 416802    195 wKLFQALKLNLFGLVLPLLVMIICYTGIIKILlrrpnEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDflftheCE 274
gi 341940331 195 wKRFQALKLNLLGLILPLLVMIICYAGIIRILlrrpsEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDvlftnqCE 274
gi 341940323 196 fLRFQALTMNILGLILPLLAMIICYTRIINVLhrrpnKKKAKVMRLIFVITLLFFLLLAPYYLAAFVSAFEDvlftpsCL 275
                        250       260       270
                 ....*....|....*....|....*....|....*...
Feature 1         #   #  ##  #                         
gi 416802    275 QSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGeRFRKYL 312
gi 341940331 275 QSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGeRFWKYL 312
gi 341940323 276 RSQQVDLSLMITEALAYTHCCVNPVIYVFVGkRFRKYL 313

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap