Conserved Protein Domain Family
7tmA_CX3CR1

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cd15186: 7tmA_CX3CR1 
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.
Statistics
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PSSM-Id: 320314
View PSSM: cd15186
Aligned: 4 rows
Threshold Bit Score: 420.008
Threshold Setting Gi: 238055160
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative chemokine binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of chemokine receptors with bound ligands (chemokines, peptides, or chemical antagonists/agonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                                #  #               #  ## 
gi 1351394    32 VFLSIFYSVIFAIGLVGNLLVVFALTNSKKpksvTDIYLLNLALSDLLFVATLPFWTHYLineKGLHnamCKFTTAFFFI 111
gi 548703     33 IFLSIFYSLVFTFGLVGNLLVVLALTNSRKsksiTDIYLLNLALSDLLFVATLPFWTHYLishEGLHnamCKLTTAFFFI 112
gi 238055160  33 VFVVILYSLVFAFGLVGNLLVVFALINSQRsksiTDIYLLNLALSDLLFVATLPFWTHYVineQGLHhatCKLITAFFFI 112
gi 50732904   32 IFLPLFYIAVFALGLAGNVMVVLAIVKEGSkksiTDIYLMNLAVSDLLFVISLPFWASNTvrgWTLGtipCKVVSSLYYI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                       ######       #  #
gi 1351394   112 GFFGSIFFITVISIDRYLAIVLAanSMNNRtvQHGVTISLGVWAAAILVAAPQFMFtkqkenECLGDYPevlqeiwPVLR 191
gi 548703    113 GFFGGIFFITVISIDRYLAIVLAanSMNNRtvQHGVTISLGVWAAAILVASPQFMFtkrkdnECLGDYPevlqeiwPVLR 192
gi 238055160 113 GFFGGIFFITVISVDRFLAIVLAanSMSNRtvQHGVTTSLGVWAAAILVATPQFMFtrekenECFGDYPeilqeiwPVIL 192
gi 50732904  112 GFFGGMFFITVISIDRYLAIVRAtySMRSRtiKHSLLITCGVWATAVLVSVPHFVFsqmfenDCIPVLPqelmniwPVFC 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                      #      #  #          #   
gi 1351394   192 NVETNFLGFLLPLLIMSYCYFRIIQTlfsCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLydffpsCDMRKDL 271
gi 548703    193 NSEVNILGFVLPLLIMSFCYFRIVRTlfsCKNRKKARAIRLILLVVVVFFLFWTPYNIVIFLETLKFynffpsCGMKRDL 272
gi 238055160 193 NTEINFLGFLLPLLIMSYCYFRIMQTlfsCKNHKKAKAIRLIFLVVVVFFLFWTPYNVMIFLQTLNLydffpkCDVKRDL 272
gi 50732904  192 NVELNTAGFFIPVCIICYCYCGIIKTllyCKNQKKARAIKLTLAVVIVFFLFWTPYNVLIFLETLRHyelfisCNQIKSL 271
                        250       260       270
                 ....*....|....*....|....*....|...
Feature 1        #  ##  #                         
gi 1351394   272 RLALSVTETVAFSHCCLNPLIYAFAGeKFRRYL 304
gi 548703    273 RWALSVTETVAFSHCCLNPFIYAFAGeKFRRYL 305
gi 238055160 273 KLAISVTETIAFSHCCLNPLIYAFAGeKFRRYL 305
gi 50732904  272 DYAMHLTETIAFSHCCLNPLIYAFAGeKFRKYL 304

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