Conserved Protein Domain Family
7tmA_CCR8

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cd15187: 7tmA_CCR8 
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors
CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.
Statistics
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PSSM-Id: 320315
View PSSM: cd15187
Aligned: 4 rows
Threshold Bit Score: 431.53
Threshold Setting Gi: 1707884
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative chemokine binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of chemokine receptors with bound ligands (chemokines, peptides, or chemical antagonists/agonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                                #  #                #  ##
gi 1707884   36 LLLAVFYCLLFVFSLLGNSLVILVLVVCKKLrsiTDVYLLNLALSDLLFVFSFPFQTYYLl-dQWVFGtvmCKVVSGFYY 114
gi 53136624  56 SFFPVLYSILFVIGLMGNALVVWVLTAFKKIramTDVYLLNLAISDLVFVFSLPFLAQYSlvsQWTFGnamCKIVSSAYF 135
gi 42557659  62 LFLPILYCLVFVFCLLGNSLVLWILLTRKRLmtmTDICLLNLAASDLLFIVPLPFQAYYAs-dQWVFGnalCKIMAGIYY 140
gi 3334152   34 LYLAILYCVLFVLGLLGNSLVILVLVGCKKLrsiTDIYLLNLAASDLLFVLSIPFQTHNLl-dQWVFGtamCKVVSGLYY 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                           ######      
gi 1707884  115 IGFYSSMFFITLMSVDRYLAVVHavYALKVRtiRMGTTLCLAVWLTAIMATIPLLVFyqvasedgvlQCYSFYNqqtlkW 194
gi 53136624 136 IGFYSSAFFITIMSIDRYLAIVHsvYALKVRttKHGIIASLALWAVAILASVPGLVFfrevdednrtQCIPHYPgsgnsW 215
gi 42557659 141 TGFYSSIFFITLMSIDRYIAIVHavYAMKIRtaSCGTMISLVLWLVAGLASVPNIVFnqqleieqsvQCVPVYPpgnniW 220
gi 3334152  113 IGFFSSMFFITLMSVDRYLAIVHavYAIKVRtaSVGTALSLTVWLAAVTATIPLMVFyqvasedgmlQCFQFYEeqslrW 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #  ##                                                      #      #  #          
gi 1707884  195 KIFTNFKMNILGLLIPFTIFMFCYIKILHQLkrcqnHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSmhilDGCSI 274
gi 53136624 216 KVFSNSEVNILGWLFPVSILIFCYHNILRNLqrchtQNKYKAMKLVFIVVIVFFLFWTPINIMLLLDSLRSlhiiDDCQN 295
gi 42557659 221 KVTTQFAANILGLLIPFSILIHCYAQILRNLrkcknQNKIKAIKMIFIIVIVFFLFWTPFNVVLFLDSLQSlliiDNCQA 300
gi 3334152  193 KLFTHFEINALGLLLPFAILLFCYVRILQQLrgclnHNRTRAIKLVLTVVIVSLLFWVPFNVALFLTSLHDlhilDGCAT 272
                       250       260       270
                ....*....|....*....|....*....|....*..
Feature 1       #   #  ##  #                         
gi 1707884  275 SQQLTYATHVTEIISFTHCCVNPVIYAFVGekFKKHL 311
gi 53136624 296 SQRLDLALELAETLSLVHCCLNPIIYAFVGekFKKYL 332
gi 42557659 301 SSQITLALQLTETISFIHCCLNPVIYAFAGvtFKAHL 337
gi 3334152  273 RQRLALAIHVTEVISFTHCCVNPVIYAFIGekFKKHL 309

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