Conserved Protein Domain Family
7tmA_ACKR2_D6

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cd15188: 7tmA_ACKR2_D6 
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.
Statistics
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PSSM-Id: 320316
View PSSM: cd15188
Aligned: 4 rows
Threshold Bit Score: 430.745
Threshold Setting Gi: 483507854
Created: 23-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative chemokine binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of chemokine receptors with bound ligands (chemokines, peptides, or chemical antagonists/agonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                                 #  #               #  ##
gi 20455469   47 VFLPVFYSLIFVLGLSGNLLLLMVLLRYVPr-rRMVEIYLLNLAISNLLFLVTLPFWGISVawhwvfgsfLCKMVSTLYT 125
gi 465995511  44 VFLPVLYTTVFLLGLAGNCLLFAILIKYTKn-kKMTEVYLLNLTISDLLFVVTLPFWAMYAasqwvfgnaFCKIISVIYT 122
gi 14547935   46 VFLPVVYSLIFVLGLAGNLLLLVVLLHSVPqrrRMIELYLLNLAVSNLLFVVTMPFWAISVawhwvfgsfLCKVVSTLYS 125
gi 483507854  49 VFLPAFYTVVFLVGLAGNLLLFVVLVLYIRkkkKMTEVYLLNLVVSDFFLLLTLPFWAMYIsqrv-twdmLCPFLNAMYT 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             ######     
gi 20455469  126 INFYSGIFFISCMSLDKYLEIVHaqpYHRLRtrAKSLLLATIVWAVSLAVSIPDMVFvqthenpkgvwNCHADFGghgti 205
gi 465995511 123 TNFYSGIFFVSCMSLDKYLEIVHgwsNKNLRapRKSFLVSSVVWVISIVLSIPDFIFmqvqdlhngrrVCHLNYGlhnsi 202
gi 14547935  126 INFYCGIFFITCMSLDKYLEIVHaqpLHRPKtrFRNLLLIVMVWITALAVSVPEMVFvkvhqtldgvwHCYADFGghati 205
gi 483507854 128 MNFYSGVFLVSCMSLDMYLQIIDacsPRSFTtqRKSILVLVAVWVLSILLSVPDGLFtttkhtnnqtiVCTRDYGqehlf 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ##                                                      #      #  #         
gi 20455469  206 WKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLvrlrpAGQGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDlqvfgnCE 285
gi 465995511 203 WQLLFQFQQILLGFFLPFLCMVFFYSRVACVLtalmsPGKKRALRLVVLLVVVFFVLWFPYNVTLFLHLLQNlhvikgCE 282
gi 14547935  206 WKLYLRFQMNLLGFLFPLLAMIFFYSRIGCVLvrlrpPGQGRALRMAAALVVVFFLLWFPYNLTLFLHSLLDlhvfgnCK 285
gi 483507854 208 WKVVFQVIQNVLGFLFPLLLMVFCYSRIACVLttsrmPGLRRALCFVFTLVGVFFVLWFPYNIVLILHSLQDvgvirsCE 287
                        250       260       270
                 ....*....|....*....|....*....|....*...
Feature 1         #   #  ##  #                         
gi 20455469  286 VSQHLDYALQVTESIAFLHCCFSPILYAFSShrFRQYL 323
gi 465995511 283 TSKHLDYAMQVTESVAFIHCCLNPLLYAFVNkrFRLHL 320
gi 14547935  286 ISHRLDYMLQVTESLAFSHCCFTPVLYAFSShsFRQYL 323
gi 483507854 288 RSRQLDYAIQITESLAFVHCCLNPLLYAFVKkrFRLYL 325

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