Conserved Protein Domain Family
7tmA_GPR25

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cd15193: 7tmA_GPR25 
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.
Statistics
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PSSM-Id: 320321
View PSSM: cd15193
Aligned: 6 rows
Threshold Bit Score: 361.762
Threshold Setting Gi: 47117808
Created: 11-Dec-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##            ###### 
gi 47117808   40 VYIPALYLAAFAVGLLGNAFVVWLLAGRRGp-rRLVDTFVLHLAAADLGFVLTLPLWAAAAalgGRWPFGdgLCKLSSFA 118
gi 528494394  42 IYIPVLYIIMFLTGSLGNLFVIVVIGKRRKksgRLVDTFVLNLALADLVFVLTLPMWAISTr-yDEWPFGevLCKISSFI 120
gi 543739171  37 IFIPILYSLIFLLGLVGNLFVIVLMAKKSRg-kRMVDTFVLNLAVADVVFVCTLPFWVAAGaqgNRWLLGegLCKLSSYV 115
gi 301623818  38 WILPTLYLIFFFFGLTGNAIVIAIVSRRSS---RRADIFILHLAISDLLFVLTLPFWASSLalgGQWSFGvhMCRASGFI 114
gi 632953580  38 VSISAVYALIFIIGFFGNLFVIIVTSFKQTt-rRPVDTFVINLAVADLVFVLTLPFWIVSTgnnHDWIFGseVCKISSYI 116
gi 556953290  39 IYIPIFYFVIFFTGLFGNVFVIAAMTLKQTt-kRLVDIFVINLAVADLVFVFTLPLWSVSAafdDQWLFGgvLCKLSSYV 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                            # #####                        
gi 47117808  119 LAGTRCAGALLLAGMSVDRYLAVVKlleARPLRtpRCALASCCGVWAVALLAGLPSLVYRglqplpggqdSQCGEEps-h 197
gi 528494394 121 IAVNRFSNIFFLTCMSVDRYLAVVRlmdSRFLRssNCAQITCGIVWVVSFFLGSPSLAYRhli-----nnSVCSEDskss 195
gi 543739171 116 IAVNRCSSILFLTALSVERYLVIRKvldTKVMGsqRHVRVTCGVIWAVSLLLGAPTLLYRrl------dgDDCWDEd--- 186
gi 301623818 115 IAVTRCASSLLMAIMSVDRYLAVIGghrIHPFRtrTCSLGACCAIWLLSLVTGIPPLVFRnl------veNVCVESsesr 188
gi 632953580 117 IGVNRYSSIFFLTSMSVDRYLSIVKlldFRHLRtqRHAIKICALIWIGSLVLAIPSAYFRklil---tnkSYCVDDkssq 193
gi 556953290 118 IAVNRYSSIFFMTGMSVDRYMAVVKlldSKFIRtrRCILITCTIIWIISLVMGIPSLVYRdlstq-dsehTYCIEDqdsi 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ### ### ##                                                       #  ## ##  #
gi 47117808  198 aFQGLSLLLLLLTFVLPLVVTLFCYCRISRRLRRpp----------hvGRARRNSLRIIFAIESTFVGSWLPFSALRAVF 267
gi 528494394 196 fVQGMNLLTILLTFLLPVLILGLCYGSILVNLRRhchnp----antrtDARRRHSVKIVFAIISAFLISWLPFNCFKAIH 271
gi 543739171 187 -GEDFSLAMVFLTFLLPLGVISFCYCSIYCRLQRhv----------rlGRGVRRSHRAIVTIVTAFLCSWLPLNACKVLL 255
gi 301623818 189 lSVGIKLATLFLTFVLPLTVVAFCYSCMAKHLWNyfggpqnvaggkakPRRRHSWLRIVSCVVAAYSLSWLPYNTLSTVR 268
gi 632953580 194 fFRGFSLASICITFGLPVIIIVFCYCSILVRLRDhydq------akktFQRRENSLKIVVAIVLTFVLSWLPFNVLKAVD 267
gi 556953290 197 iFKGISLASLFLAFVLPVIIILFCYCSISARLYShfhh------anryDQKRKKTLKIIFTIITAFVCSWLPFNTFKTLY 270
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1                         ## ###  #  ##                     
gi 47117808  268 hlarlgalplpcplllaLRWGLTIATCLAFVNSCANPLIYLLLDrsFRARA 318
gi 528494394 272 valliingdlnedtyvvIHRGLMLSCCLAFLNSCVNPAIYFFLDqhFRRRA 322
gi 543739171 256 fflakgmlvlsqgqevaLRWLVATSTCLAFVNSCVNPLIYALMDghCRPRC 306
gi 301623818 269 lvaelgeg-fpchttvaINQALSATAAIAFANSCTNPLIYSILDagFRHRT 318
gi 632953580 268 lylqsegiipncalsqaISQGLVIASCLAFVNSCMNPIIYISLDrhFRRRA 318
gi 556953290 271 llfsfqgk-mppcrvgiLRQGLTITACFAFLSSCVNPIIYTFLDnhFRKRA 320

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