Conserved Protein Domain Family
7tmA_GnRHR-like

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cd15195: 7tmA_GnRHR-like 
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.
Statistics
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PSSM-Id: 320323
View PSSM: cd15195
Aligned: 7 rows
Threshold Bit Score: 380.975
Threshold Setting Gi: 283806330
Created: 24-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #  ##          ######
gi 84095064   32 VSKLCVLGTVFVISFFGNTLVIIQIFRIRGsr--stIQSLILNLAIADLMVSFFNILMDIIWSAtveWLAGNtmCKIMKY 109
gi 148227062  54 KIRVAITCVLFIFSACFNIAALWTITYKYKkk--shIRILIINLVAADLFITLVVMPLDAVWNVtlqWYAGDlaCRVLMF 131
gi 112983116  42 MVSMTVYSVLMVISATGNLTVLYQLVRRRRakrasrLDILLMHLAVADLMVTFLMMPLEIAWAGtvqWFAGDlmCRVMMF 121
gi 28394184   45 LVRVLVTWLLFCLSMAGNMFVLWSLRGSKS------RHFIMFYLALSDLIYTIFVMPSDAVWNTtmeWLAGDvmCRLCQM 118
gi 58339159   66 LTRVIITWILFLVSTCGNSFVLYCLCKQKQrl---hVHVITMHLTLADLAFTFFSMPMDATWNTtmaWLGSEflCRLCQF 142
gi 185134947  51 LFRILTLSAIFLISVPLNIIVLIIVFRRRRhk--srVNILVMHLTLADLFVALINIPTDVVWFYtvrWLAGNamCKIIMF 128
gi 283806330  52 LTRIWVTWVIFFISLAGNLTVLVSVTVMRKtqsyshCQLIMTHLSLANLAFTLFILPMDAIWNYtleWLAGDvmCRVMNS 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                          # #####                         
gi 84095064  110 LTVFGLHLSTYITVSIALDRCFAILSPmsrskaplRVRIMITMAWVLSAIFSIPQAVIFqeqrkm-----frqgmFHQCR 184
gi 148227062 132 LKLAAMYSSAFVTVVISLDRQAAILNPlgigdakkKNKIMLCVAWFLSYLLAIPQLFVFhtvsr------sepihFVQCA 205
gi 112983116 122 TRTFGLYLSSFVLICIAVDRYYAILKPlnvt-weaTVRRAIIVAWVCAGLASLPQSFIFhveeh------pevkgYNQCV 194
gi 28394184  119 MKQFGMYASSFMVVVIGMDRVTAILSPlthegqrkRGYCMVLAAWTTSLLCCIPAGALFslltve----tceginVYQCV 194
gi 58339159  143 LKQFGMYISSLMVVVIALDRVFSILSPmsanqqrkRTKILLISAWTLSLLCAIPALFLFslirkqf---cpdqpiFHQCV 219
gi 185134947 129 IESFNMYGSSFILIVISLDRYAAIVHPlsihqadrRCKIMVRAAWTCSALCSVPQFLVHevlsp------yeapdFTQCV 202
gi 283806330 132 LKQFAMYISSAMIMVMGVDRVTGLLRPvsanqqrrRIVKFLTVAWVFSFINSIPPSVMFsagpywpmrcecpnhyVVQCV 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                                        
gi 84095064  185 DSyna---lwQKQLYSASSLILLFVIPLIIMVTSYLLILKTIvktsrqfhdtpisptsmscysvnhgqirthlfeRARKR 261
gi 148227062 206 TVgsfq-ahwQETIYNMFTFFCLFLLPLLIMVSCYTRILMEIshkmkatcvssk---------eidlrrssnnipRARMR 275
gi 112983116 195 SYgslp-tekHEFAYFLVNMILMYVIPLVSTLYCSCAALFEIirrantandk-------------mrrsgigllgRARAR 260
gi 28394184  195 DFnivk-drsLLRPYYFFTMCMSFLLPLICTLVSYSLIVCEIsnmkerdrvlmg----------rrksvntasiqRAKNR 263
gi 58339159  220 DFsrni-nkqDLKPYYFFTMCVSFLIPLFFTVISYSLILCEInamqrrderi--------------tgrrdnnieRARMK 284
gi 185134947 203 DYrfafehptLWRLYHVFVTLAMYVVPLITIFTCYAAIIYKIcrktkqarqsinnn-----essvlrrscssslpRARMK 277
gi 283806330 212 DFhli---kkGREIFYIYSMFISFFIPLYCIIICYLIIAFSIakmakrakatelqssg-frppssrkslarrslqRAKKI 287
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                       #  ## ##  #              ## ###  #  ##                     
gi 84095064  262 SSRMSAVIVAAFILCWTPYYIIFLGFAFfq--------wdNSRTVIYFFTLGTSNCMLNPLIYGAFTiYKVHRG 327
gi 148227062 276 TLKMSLVIVLTFIVCWTPYYLLGIWYWFspeml--teekvPPSLSHILFLFGLLNTCLDPIIYGLFTiHFRREI 347
gi 112983116 261 TLKMTVTIVLVFFTCWSPYYCYCLWYWIdkes----iknlDPALQKAMWLFSCTNSCANPIVYGVFNrNRWNWR 330
gi 28394184  264 TILMRTLITLTFLVCWGPYYGKGIYDWFqkpa-----igpPAPLDTAMYIVMYLNPVLHPIVFGVFMkEIRSKF 332
gi 58339159  285 TLVLTSLVTLSFIVLWGPYYAMGIYHWFnpie----ratfPKEISVGLFVLMYFHPAVHPILYGFFMkDIRKHF 354
gi 185134947 278 ALRLTATIVTAFIMCWGPYYVLSTWYHFdirwqtgaglpnPDWMIHIMMALGYSNICLDPIIYGIFItRFSLCQ 351
gi 283806330 288 SQLVTGLITITFVICWGPYYVVGLMHWFneq-------riERLPEGIMLMSLYLNPCLHPFITVCLMkEIRENI 354

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