Conserved Protein Domain Family
7tmA_GPR31

?
cd15199: 7tmA_GPR31 
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and subendothelial matrix, which is a critical step for metastasis.
Statistics
?
PSSM-Id: 320327
View PSSM: cd15199
Aligned: 4 rows
Threshold Bit Score: 354.098
Threshold Setting Gi: 209735618
Created: 4-Jan-2014
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##               ###
gi 60416427   15 TAVGVLLGLECGLGLLGNAVALWTFLFRVRvw--kpYAVYLLNLALADLLLAACLPFLAAFYLsl---qaWHLGrvgCWA 89
gi 209735618  22 KFYASVMIMEFTLALPLNLSVLYLFIFKLKfwksntNNIFLFNLVLADVLLLICLPVKAYHFLng---nrRSTEggtCKA 98
gi 126311278  15 ISIASLLILEFALGLMGNAIALWTFISHLKvw--kpYAVYLLNLVIADLLLSVCLPFQISFYLmh---kkWELGpaaCRI 89
gi 465952929  15 IAMNILLILEFGLGLTSNAIALWTFYFRLKiw--kpHAVYLLNLVIADVLLNICLPFRLLLALrfsiletWDYKelfCSV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ### ##  #                                             # #####                   
gi 60416427   90 LHFLLDLSRSVGMAFLAAVALDRYLRVVHPrLKVNLLs-pQAALGVSGLVWLLMVALTCPGLLiseaaqnsTRCHSFysr 168
gi 209735618  99 MLFMLFLNRGASIAFLTVISVDRYFNVVHP-GKKNFAkalKKSPYISFLIWLLLLPLTIPTMLks-----fECCNSYgrk 172
gi 126311278  90 LIFLVSLSRTSGIAFLTAVAMDRYLRVVHPrFKINSFs-tQAAKIISVFVWLLVVGLAHPVLVapkiekntTECPSFspm 168
gi 465952929  93 ILFMLSLSQAVSIAFLTAVALDRYFRVVHPnNKTSSLi-aRNARVTACLVWLLAIGLTVEILVapqp-ktfTECRRFspq 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #  ### ### ##                                                #  ## ##  #
gi 60416427  169 a---dgsfSIIWQEALSCLQFVLPFGLIVFCNAGIIRALqkrlrepekqPKLQRAQALVTLVVVLFALCFLPCFLARVLM 245
gi 209735618 173 ddtlvedvTDTLREVVFFTQILIPFFVLVYCTVRIVNRLkkkt--vgdsTKLRRAVFLVTSVMLVFSFCFLPCTIARMVL 250
gi 126311278 169 e---dltfSNTWQEAVICFQFLLPFSLILFCNIRIIKRLqqrlldqdkqPKLQRSMALVTIVVVFFGICFLPSFLARILM 245
gi 465952929 171 g---eanfYSIWYVIVFFLEFLVPFGLILFCTVGIIRKLkksprdlssqPKLQKAMLLVIAVVVVFGVCFLPSVLGRVLV 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
Feature 1                      ## ###  #  ##                     
gi 60416427  246 hifqnlgscralcaVAHTSDVTGSLTYLHSVLNPVVYCFSSptFRSSY 293
gi 209735618 251 lifrikdlqnaeniAVQLYDGLMVLSYMDCLVDPIVYCLSStkFKSLY 298
gi 126311278 246 aifqrsescwilqvMVHTCDITNCFTYLNSVLNPIVYCFSNpvFRYSY 293
gi 465952929 248 yilqnfescaafrfAVNVFDVTVCWTYFNSAMDPIVYCFSSptFRSSY 295

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap