Conserved Protein Domain Family
7tmA_OXER1

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cd15200: 7tmA_OXER1 
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.
Statistics
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PSSM-Id: 320328
View PSSM: cd15200
Aligned: 5 rows
Threshold Bit Score: 399.529
Threshold Setting Gi: 507635098
Created: 4-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ###########################                                                    
gi 74762623   93 AFLAPILALEFVLGLVGNSLALFIFCIHTRpwtsNTVFLVSLVAADFLLISNLPLRVDYYLlhetWRFGaaaCKVNLFML 172
gi 465962962  11 VTIASVLGVEIVIGLVGNGIALSIFCSYRNlwpsSTMYLFSLVIADFFLIINLPFRIHYYMknevWVFTetfCSVNLFML 90
gi 611982918  14 AFLAPVLTLECIVGLVGNGFAFFIFCVHIRpwksNTIFLLCLVIADFLLIINLPFRIDYYVngqkWNFGpgaCKANLFMM 93
gi 564252395  13 KILVPVLGIEYVMGIIGNGIALIIFCFNRNfwksSTMYLLSLVVADFFLITSLPFRMHYYTrnevWTFSkrfCQVNLFML 92
gi 507635098  76 AFMAPVLAIEFVLGLLGNGVALLIFCFRLRpwtsNTVLLVCLVVADFFLVANLPLRVDYYLceemWRFGataCQVNLFMI 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74762623  173 STNRTASVVFLTAIALNRYLKVVQPHHVLSRAsvGAAARVAGGLWVGILLLNGHLLLstf----sgPSCLSYrvgt-kps 247
gi 465962962  91 SMNRTASIVFLTAIAMDRYFKVVHPHHELSKIstSCAAKVAIALWIIVILVNSHVFTldhn-qsknSACQSYnphl-epq 168
gi 611982918  94 STNRTASIIFLTAVALNRYLKVVWPHHTLSRAsaRSAAQVSVGLWVLILLMNMPLLLqdhqpvysnFSCLSFtins-tgs 172
gi 564252395  93 SMNRTASIVFLTVIAVDRYFKVVHPHHQLSKLsiPCAAKIAALIWILCILLNIHIFTlhvv--qdnTTCRGYdhpkadis 170
gi 507635098 156 SANRTASVVFLSTVALNRYLKVVHPHRALSQAsvGTAAWVAAGLWGGILLLNCHLLLsss----agSTCLSYqlgt-nss 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74762623  248 aSLRWHQALYLLEFFLPLALILFAIVSIGLTirnrglggqAGPQRAMRVLAMVVAVYTICFLPSIIFGMASmvafwls-a 326
gi 465962962 169 aAATWHTILFFLEFFLPLGIIMFCIFNIILKlkqrklakrNKVQRSVKVLTVIVLVYTVCFLPTILIAAVGlvtlkvs-- 246
gi 611982918 173 iPQRWHHILYVLEFFLPLGIILFSIFSIIITirrrkldkqAGTRRAVLVLGVIVTVYISCFLPSIVFAIASilaqrvs-n 251
gi 564252395 171 lVDHWHRMLIFIEFFISLGIIFFCIFRVLFKlkqkemargKRIQRTMKLLIIIVLVYSVCFSPVILFALAVlivwkvspq 250
gi 507635098 231 aSDRWHELLFGLEFLLTLGLVLFAVASIRRTvqrrglggqAGPRRALRVLAVVVAVYAICFLPALVFGTATiaafelg-s 309
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
Feature 1                                                
gi 74762623  327 crsldlCTQLFHGSLAFTYLNSVLDPVLYCFSSpnFLHQS 366
gi 465962962 247 pehigtIDQLLRASFAFTYLNSALDPVLYCFSSqvFLNRC 286
gi 611982918 252 cqtlnlCTELFHGALAFTYLNSTLDPMLYLFSSpsFLHQS 291
gi 564252395 251 slsykvMNQLFHASFAFTYLNSALDPVLYCFSSvtLQNRF 290
gi 507635098 310 crifdlCAQLFHGSLAFTYLNSALDPVLYCFSSpsFLRQI 349

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