Conserved Protein Domain Family
7tmA_HCAR1-3

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cd15201: 7tmA_HCAR1-3 
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.
Statistics
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PSSM-Id: 320329
View PSSM: cd15201
Aligned: 13 rows
Threshold Bit Score: 416.759
Threshold Setting Gi: 47226430
Created: 4-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##            ###### #
gi 47117701   16 QVMPPLLIVAFVLGALGNGVALCGFCFHMKtwkpSTVYLFNLAVADFLLMICLPFRTDYYLrrrhWAFGdipCRVGLFTL 95
gi 47226430   10 SVLPSLLGAEFVLGGLGNGLALWIFCCHLKpwksSTVLLFNLAMADFLLIMALPFRASYYNaglqWMYGeamCNICLFML 89
gi 47228478   28 RVLPPILLLEFTFGLMGNFVALSMFIFYMDswkpNSVYLTHLAVADSIVLFCLPFRADYYRrgkdWLHGdvaCRILLFML 107
gi 209973127  18 EVLPPVLFSEFVLGLMGNGLALCMFFFHRDswkpNSIYLAHLALADSLVLFCLPFRADYYRrgkhWVYGdafCRVLLFLL 97
gi 48474437   16 QVMPPLLILVFVLGALGNGIALCGFCFHMKtwksSTIYLFNLAVADFLLMICLPLRTDYYLrrrhWIFGdiaCRLVLFKL 95
gi 657813390  12 TVLPPVLLMEIVLGILANGFALWIFCFQLKpwksSTVLLFNLAVADFLLIMALPFRASYYLsginWMFGesvCNIILFML 91
gi 512811130  16 YLLPPVLILVFVLGSLFNGLSLWIFCFHNKswkaSTVWLFNLALADFLLMVCLPFRTDYYLrhkhWQYGdipCRLVLFVL 95
gi 498957511  12 NVLPPLLMTEFVLGVLGNGLALWIFCFHLRpwksSTVLLFNLAMADFLLNIVLPLRASYYFagikWKFGnalCNICLFML 91
gi 556955070  16 SVLPPVLIVEFVLGLAGNGVGLWMFCFHMKnwkpNSVYLLNLAVADFVVLFCLLFRTDYYLrkknWVYGdipCRVLLFML 95
gi 556955067  17 YILPPFLILEFVFGLVANGIALWIFCFNMKrwkaSTLYLFNLALADFLLIFCLPFRTDYYLkkknWTHGdafCSLVLFML 96
gi 573905424  21 YVLPPVLLVECLLATLGNGIALWIFCFHLKpwktSTVFLFNLALADFLLSIILPFRTSYYVrgkdWIFGdvfCRISLFML 100
gi 519668680  28 KVLPPVLGLEFIFGLLGNGLALWIFCFHLKswksSRIFLFNLAVADFLLIICLPFVMDYYVrrsdWKFGdipCRLVLFMF 107
gi 74762622   28 KVLPPVLGLEFIFGLLGNGLALWIFCFHLKswksSRIFLFNLAVADFLLIICLPFLMDNYVrrwdWKFGdipCRLMLFML 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 47117701   96 AMNRAGSIVFLTVVAADRYFKVVHPHHAVNTIstRVAAGIVCTLWALVILGTVYLLLenhlc--vqetaVSCESFim--- 170
gi 47226430   90 AMNRSGSTVFLMAIAGDRYMRVVHPHHRINSLsvSRATCFVMGLWLLTITMTAHVFSlkh------tntTYCESFmvdte 163
gi 47228478  108 AANRAAGIFFLTAVAVDRYLKIVHPRNRINQMglCYAFCVCVGLWALICLATGYLLFeehff--ihgnrTQCESFnicmg 185
gi 209973127  98 AANRAAGIFFLTAVAVDRYLKIVHPLNRINQMglRYALWVSVGLWALIIAMTVYLLAdkhfy--yrnnrTQCESFniclg 175
gi 48474437   96 AMNRAGSIVFLTVVAVDRYFKVVHPHHMVNAIsnRTAAATACVLWTLVILGTVYLLMeshlc--vqgtlSSCESFim--- 170
gi 657813390  92 AMNRSGSTFFLMAIALDRYMCVVHPHHPINSVsvSKAMLGALILWLVPVAMTAHVFSlkh------vntTKCESFviete 165
gi 512811130  96 SMSRSGSIFFLTLVATDRYFRVVHPHHRINSVstMCAAGIACVVWLITIAGSVFILTkrrefsggregfLACESFaic-- 173
gi 498957511  92 ALNRSGSTFFLMAIAVDRYMRVVHPHHPINSLsvSKAIIGALGLWLITTSMTAHVFSlsh------intTYCESFmidtk 165
gi 556955070  96 AANRASGTIFLTVVAIDRYFKIVHPHHRLNWIsiKDSVLIACGLWVIIISMTMYLLAkphlf--pysnlTQCESFnicpa 173
gi 556955067  97 ALNRAGSIVFLTAVATDRYFRVVHPHHRINAIsvKSAAILAGVLWTLTIGMTAYLLTdshlf--pyqnlTQCDSFtict- 173
gi 573905424 101 AMNRGGSILFLTAVAVDRYFRVVHPHHPVNSMsiAKAACFACALWALAIAMTVYLLTmphhf--cfenaTHCESFttith 178
gi 519668680 108 AMNRQGSIIFLTVVAVDRYFRVVHPHHALNKIsnWTAAIISCLLWGITVGLTVHLLKkklli--qngtaNVCISFsi--- 182
gi 74762622  108 AMNRQGSIIFLTVVAVDRYFRVVHPHHALNKIsnRTAAIISCLLWGITIGLTVHLLKkkmpi--qnggaNLCSSFsi--- 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #  ### ### ##                                                #  ## ##  #     
gi 47117701  171 -esANGWHDIMFQLEFFMPLGIILFCSFKIVWSLrrrqq-larqARMKKATRFIMVVAIVFITCYLPSVSARLYFlwtvp 248
gi 47226430  164 pshNLSWHKFEFLFSFIIPLVVILYCTVHIIGKLrgrq--laqhEKTKKALCFLTVVVVLFTICFLPSNLMQVLIwvetq 241
gi 47228478  186 fspLSTWHNTFYIVQFFLPTAIVAFCTLRITWQLrdrnrtldrsGKIKRAVQFVMAVALIFITCFFPSTISRIAVwilkv 265
gi 209973127 176 hnaLSDWHNSFYVIQFFVPTFIVIYCSTCITWQLkgkt--idkhGKIKRAVRFVLAVALVFIICFFPSNVSRIAVwvlks 253
gi 48474437  171 -esANGWHDVMFQLEFFLPLTIILFCSVNVVWSLrrrqq-ltrqARMRRATRFIMVVASVFITCYLPSVLARLYFlwtvp 248
gi 657813390 166 tdhSLNWHKTVFLLSFYLPLSMIIYCTFHIVVQLrrrr--lgqqAKMKRALCFIAVVVILFIVCFLPSNITEVLIwikth 243
gi 512811130 174 ldySEKQHDYIYLVQFFVPLATVAFCSCRVILRLrqrn--ldrhAKIKRAVQCMVLVGMAFCFCFLPSVSTRIEMlrlld 251
gi 498957511 166 tkgNLSWHKFAFLFSFYMPLLVILYCTFCIVRNLkgrq--laqhAKIKKALYFIIVVVVLFIICFLPSNFTQLVIwiksy 243
gi 556955070 174 tdsSANWHEAYYISQFLIPVCIIAYCTVRITWQLkskt--idkqGKIRKAVQFVLAVAIVFTVCFCPSNMVRIAIwfiks 251
gi 556955067 174 sasSAVWHNLLFLAEFTIALCIILYCTYQIIMQLrqrq--mdkqEKVKKTVKLVSIVAVVFIVSFLPSVLARVHIwilkg 251
gi 573905424 179 hgsDSVWHEALYFLEFVVPLAVTLYCSLQIICQLkgrq--vgkhSKIRRAVYFVGAVVMVFVICFFPSNVTRLVIwakka 256
gi 519668680 183 -chTFRWHEAMFLLEFFLPLGIILFCSARIIWSLrqrq--mdrhAKIKRAITFIMVVAIVFVICFLPSVVVRIHIfwllh 259
gi 74762622  183 -chTFQWHEAMFLLEFFLPLGIILFCSARIIWSLrqrq--mdrhAKIKRAITFIMVVAIVFVICFLPSVVVRIRIfwllh 259
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1                         ## ###  #  ##                     
gi 47117701  249 s----------sacdpsVHGALHITLSFTYMNSMLDPLVYYFSSPsFPKFY 289
gi 47226430  242 rraralppaelcpalegMTNAFFLTISLTYFNSVLDPVIYYFSSPaIQNLF 292
gi 47228478  266 wyn-------ecqyfeeANLAFYTSVCFTYFNSVLNPLVYYFSSPaFTGTF 309
gi 209973127 254 whn-------ecqyfqdANVAFYITVCFTYFNSVLNPVVYYFSSPaVSRSL 297
gi 48474437  249 t----------sacdpsVHTALHVTLSFTYLNSMLDPLVYYFSSPsLPKFY 289
gi 657813390 244 qvvhslpqseicpameeMTNTFFISISLTYFNSAMDPLVYYFSIPaFKNIC 294
gi 512811130 252 spqw-----qdcniyrgADTAFYISICLTYMNSMCNPLLYYFSSPsFQAFY 297
gi 498957511 244 klags---snmcsemenLTIVFYITISLTYLNSVLDPVVYYFSSPvFKSIC 291
gi 556955070 252 qys------hdckhfreANLAFYTSVCFTYFNSLLNPIVYYFSSPtFNGMF 296
gi 556955067 252 nsv-------dctllrsVDVAFYITICFTYFNSMLDPVVYYFSSSlFKSFY 295
gi 573905424 257 hhi------edcdsyksLDDAFFITVSLTYFNSVLDPVVYYFSSPtFKRIY 301
gi 519668680 260 tsgt-----qncevyrsVDLAFFITLSFTYMNSMLDPVVYYFSSPsFPNFF 305
gi 74762622  260 tsgt-----qncevyrsVDLAFFITLSFTYMNSMLDPVVYYFSSPsFPNFF 305

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