2KS9


Conserved Protein Domain Family
7tmA_TACR-like

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cd15202: 7tmA_TACR-like 
Click on image for an interactive view with Cn3D
tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.
Statistics
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PSSM-Id: 320330
View PSSM: cd15202
Aligned: 4 rows
Threshold Bit Score: 383.009
Threshold Setting Gi: 310942510
Created: 24-Jul-2013
Updated: 26-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##            ###### 
2KS9_A        33 VLWAAAYTVIVVTSVVGNVVVMWIILAHKRmrtvTNYFLVNLAFAEASMAAFNTVVNFTYAvh-neWYYGlfyCKFHNFF 111
gi 8118100    56 VLLSIFYGIISLVAVAGNFMVMWIVATSRRmqtvTNFFIANLAVADIIIGLFSIPFQFQAAll-qrWVLPefmCAFCPFV 134
gi 212276435  72 ALLIVAYSFIIVFSLFGNVLVCHVIFKNQRmhsaTSLFIVNLAVADIMITLLNTPFTLVRFvn-stWIFGkgmCHVSRFA 150
gi 51704225  106 IIVYMLYIPIFIFALIGNGTVCYIVYSTPRmrtvTNYFIASLAIGDILMSFFCVPSSFISLfilnyWPFGlalCHFVNYS 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                          # #####                          
2KS9_A       112 PIAAVFASIYSMTAVAFDRYMAIIHPlqpRLSATATKVVICVIWVLALLLAFPQGYYsttetm-------psrvvCMIEW 184
gi 8118100   135 QVLSVNVSIFTLTAIALDRYRAVMSPlkaRTTKLRAKFIICGIWTLAVAAALPCALAlrvetqveshalnltkpfCHEVG 214
gi 212276435 151 QYCSLHVSALTLTAIAVDRHQVIMHPlkpRISITKGVIYIAVIWTMATFFSLPHAICqklftfky--sedivrslCLPDF 228
gi 51704225  186 QAVSVLVSAYTLVAISIDRYIAIMWPlkpRITKRYATFIIAGVWFIALATALPIPIVsgldipmspwhtkcekyiCREMW 265
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #  ### ### ##                                                        #  
2KS9_A       185 PehpnkiyEKVYHICVTVLIYFLPLLVIGYAYTVVGITLwaseipgds-sdryheqvSAKRKVVKMMIVVVCTFAICWLP 263
gi 8118100   215 Isr---kaWRIYNHVLVCLQYFFPLLTICFVYARMGLKLkeskspgnaqgardagilKNKKKVIKMLFVIVALFAFCWLP 291
gi 212276435 229 Pepa-dlfWKYLDLATFILLYILPLLIISVAYARVAKKLwlcnmigdvtteqyfalrRKKKKTIKMLMLVVVLFALCWFP 307
gi 51704225  266 Psr---tqEYYYTLSLFALQFVVPLGVLIFTYARITIRVwakrppgeaetnrdqrmaRSKRKMVKMMLTVVIVFTCCWLP 342
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1        ## ##  #           ## ###  #  ##                     
2KS9_A       264 FHIFFLLPyinpdlylkkfIQQVYLAIMWLAMSSTMYNPIIYCCLNdrFRLGF 316
gi 8118100   292 YQLYNILRevfpkidkykyINIIWFCTHWLAMSNSCYNPFIYAIYNerFKREF 344
gi 212276435 308 LNCYVLLLsskv----irtNNALYFAFHWFAMSSTCYNPFIYCWLNenFRIEL 356
gi 51704225  343 FNILQLLLndeef-ahwdpLPYVWFAFHWLAMSHCCYNPIIYCYMNarFRSGF 394

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