Conserved Protein Domain Family
7tmA_prokineticin-R

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cd15204: 7tmA_prokineticin-R 
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.
Statistics
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PSSM-Id: 320332
View PSSM: cd15204
Aligned: 19 rows
Threshold Bit Score: 397.802
Threshold Setting Gi: 229270983
Created: 26-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##              #####
gi 222876512   67 IVIGVALVGIMLVCGIGNFIFIAALARYKKlrnlTNLLIANLAISDFIVAIVCCPFEMDYYvvr-qlsWEHGhvlCASVN 145
gi 229280691   62 WVLGALYLVIMLVCGVGNALLLAVLARFREarttTNLLIGNLALSDWLVAVFRLPFAFDYYvvr-srsWQFGdfmCGAVN 140
gi 229279801   74 IAIGVLYSLIMLVCGVGNFLLLLVLLLYKEtrttTNLLIGNLALSDLLVSLLCLPYNMDYHvvh-agsWRHStalCAVVN 152
gi 229284529   17 AALGVVYSLIIMVCGVGNTLLLLVLFKYKKtrntANLLIANLALSDLIVAVCCIPFDMDYYvvr-prvWAHGnaaCAIVN 95
gi 229294385   62 VILGIVYCLIMLVCGTGNSLLITAVCRFRElrcvANVLVANLALSDLLVAVFCLPFQLDYYivk-nesWGYGdfmCATVN 140
gi 229291683  708 VALGAVYILIIVVCGVGNFVFLAIVGRYKKartkTNLLIANLALSDFVVAILCIPFSLDYYvin-drdWRYGrevCTLVN 786
gi 229294584  660 VFLGIVYCLIVMTCGFGNLLLISVIVWFKKartmTNTLIANLALSDFLVAVFCLPFNLDYYiik-srmWTHShvtCVAVH 738
gi 229298335   54 IFLALVYILIICVCGVGNLLLLIVIAAYKKmrtiTNALIANLAFSDFIVAVVCMPLIMDYYivrpdryWTYSdttCTVIN 133
gi 229293013   41 IFLCTVYSITMLTCGVGNLLLMVVIAKYKEmrtiTNALVANLALSDFLVAVFCVPFILDYHivrpnrpWTYGdvtCAVVN 120
gi 229270983    5 IFVGTIYVATIVTCGIGNILLMATIIMYKKmrtvTNALIANLAFSDFIVSVVCVPFIIDYYvvraerpWFYGdtiCAVIN 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         # ##  #                                           # #####                       
gi 222876512  146 YLRTVSLYVSTNALLAIAVDRYLAIVHPlkpr-mnyQTATILIALVWIVSILVAIPSAYFatetvlfivknqekiFCGQI 224
gi 229280691  141 YLNSVSLYVSTHALLVIALDRFMVVKQSgslr-vtrRRLIPIFSAVWLSAILLAIPSAVFsktaef----lngdiFCAVS 215
gi 229279801  153 FFTSVSHYVSTHALLAIGVDRYLVVQNArt----rrFNPCWTSVVIWVTALVLALPGAIFsrtvpy---qrqdsvFCGVL 225
gi 229284529   96 FVKTVSMYVSTNALLVIALDRYIVLYHPqrr--mgsVLSLVAVGLVWGVSLLVSVPTALYsvtisa---vggdgaICVQM 170
gi 229294385  141 YVRTMSLYVSTNVLVAIAIDRYYIVVHRpmq---qrRRAWVMIIPVWLTSMIFALPSAVNsktmmn---hrnstvFCGQA 214
gi 229291683  787 YVKMVSLHVSTNALVVIGIDRYITIVRHrwrr-lgkTSAILVSLGVWIASFLIAIPSAKFsmvqsg---fhrnnaFCGVV 862
gi 229294584  739 FLRQTSLYVSTNALLVIAIDRYLVIMLPhipr-msaRVAGAAVTMVWVVSLLVSIPAAMStkvvpy---anngntFCGQI 814
gi 229298335  134 YLRMASLYVSTNSLLVIAIDRYVVIVCTsvar-mspRVAFIVTALVWVVSMLLAIPVAIYseaveh---anggsaFCGQV 209
gi 229293013  121 YARMSSLYVSTNALLVIAVDRYVVIMMPhipr-msrAVATCVVLAVWVCSMLVAIPTAVYsralyy---vdfhgtICGLV 196
gi 229270983   85 YLRMASLYVSTNSLLLIAVHRSVSFSISgtrpnkkkRNPSHVILLVWLVSLLLAVPAAVYsrafpy---tatgsnFCGQI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #  ### ### ##                                                        #  
gi 222876512  225 WPVdqqmyYKSYFLFIFGIEFVAPVITMTLCYARISRELwfktvpgfq-teqirkrlRCRRKTVMVLMCILTAYVLCWAP 303
gi 229280691  216 YPIwhrrlYQGFTLILFAGEYVLPVCLMCACYAYIGYRVcnrrfpghr-nqsqdrsrRRSRRKTVRLVVLVAAFIVCWGP 294
gi 229279801  226 WPVslqqvYKGFHIFLVVGEFAIPAVVMSVFYSVVVYKVwrrqfpgqr-nasharvqARSRRKSIRLFALFIMFVLCWTP 304
gi 229284529  171 WPIrqyraSRAYFLFTIVGEFALPVLVMGVCCVLVVRKVwqrilpgqr-tdaqrrllARSRRKVVQLAVKFFMFVVCWGP 249
gi 229294385  215 WSVrstkyYQAYYVMMFIIEYLVPIITMTYCHLTLWLKVhrrscpgnt-nerqqqtlARSRRKTVTLVILSSLFVLCWGP 293
gi 229291683  863 WNAkhlavYRGYYGGMLAFQFVLPVVVMAVCSLPVVWKVfhrelpgnl-teamrekvQRSKRKTLRLILILALFVLCWAP 941
gi 229294584  815 WPIqeearYKAYYLSMLVLEFLIPVIIMTFCYVFIVRKIwkrqvpgfrtdeqnqsimRSKRRSVRLLVVVLVLFVLCWGP 894
gi 229298335  210 WPVhvenmYKAYYLTLFILQFALPVLIMGFCYIRIGLRIwyrtvpghqtdeqqmriqQSKRRVVRLLMVIVVIFTLSWFP 289
gi 229293013  197 WPIghqvrYKAYYVAVLLLEFIIPVLIMSFCYIRIARRIwyrtvpgqqtesqqaamlKSKKRNVRLLIVILVMFVLCWGP 276
gi 229270983  162 WPArlepmYKAYYMLLFLLEFVLPVIIMCFCYIRIALHIwyrpqtgqv-ghlpperqHHREKVIQLLIVTLLCFIVCWLP 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1         ## ##  #              ## ###  #  ##                     
gi 222876512  304 FYGFTIVRDFfptif--vkekhYLTAFYIVECIAMSNSMINTMCFVTVKnNTMKYF 357
gi 229280691  295 MYSFTIIRDFsydli--shvshSTAIVYVLDGLAMSNSVISTVVYVFANdNVMKHV 348
gi 229279801  305 YHVYSILRDFyigvl--akistSLNLFYMVQAIAMGNSLMNTLVYVVFNdNITRYV 358
gi 229284529  250 YHGVIVARDFfpsssiatgapgTFNIFYIVEAVAMSNSVINTLVYVGFNtSVMAQL 305
gi 229294385  294 YQGYTLARDLsplll---keklNTAIFYAVEALAMGNNVVNTVLYVALNaKIRKYI 346
gi 229291683  942 YYVYAALRDFhhvlt---lsalNTNIFYAVEAAAMGNSVINTCVYVAFNtNVTNFL 994
gi 229294584  895 YHGYSVARDYfpysl--sknklNLPIFYVVEALAMGNSMINTVVYIAMNdSIKKYI 948
gi 229298335  290 YYIYAIIRDWfpeil--hdthhNTTIYFIVEALGMSNSMVNTIVYIVMNkSARKHI 343
gi 229293013  277 YYGYAVVRDFfprll--aksrlNITLHYIVEAVAMGNSSIDTVVYIAMNgNVRKFM 330
gi 229270983  241 YHVYAIVRDFaphll--lvsryNTTLFFIVEALGMAQGMVNTIIYIGMNsAVRQHM 294

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