Conserved Protein Domain Family
7tmA_NPFFR

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cd15207: 7tmA_NPFFR 
neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.
Statistics
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PSSM-Id: 320335
View PSSM: cd15207
Aligned: 22 rows
Threshold Bit Score: 376.577
Threshold Setting Gi: 229295683
Created: 29-Sep-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##                   
gi 13878604  148 AIFIISYFLIFFLCMMGNTVVCFIVMRNKHmhtvTNLFILNLAISDLLVGIFCMPITLLDNii----------------- 210
gi 13878599   44 AMFIVAYALIFLLCMVGNTLVCFIVLKNRHmhtvTNMFILNLAVSDLLVGIFCMPTTLVDNli----------------- 106
gi 229296309   8 ALFGVSYFLIFALCVVGNTLVCFVVIKIPRmrtvTNYFILNLAVSDLLVGIFCMPFTLVDNiv----------------- 70
gi 229281414  14 GLIIMSYALVFLLCVVGNVIVCGVVIKTPRlrtvTNYFILNLAVSDLLVAIFCMPFTLVEHilpgkymdvhkdhepg-ha 92
gi 229281300 134 GLIVLAYSLVFLLCVIGNILVLIVVIRTPRtrtiTNYFILNLTISDLLVGIFCVPFTLVNHif----------------- 196
gi 229296253  38 ALYILVYSLVFILCVLGNLAVCWVVAKTRKlhtaTFYFIFNLAIADLLVAIFCMPFTLVSHil----------------- 100
gi 229281406  36 VVFVIGYLSVFVVCIIGNILVIYVVMKIPRmrtvTNYFILNLATSDLLVAIFCIPFTLVDNii----------------- 98
gi 229289971  36 IIFVVLYVIVFLLCIVGNLVVCCIIARTATlrdvTHSFILNLAVSDLLVGVFCIPFTLVGHif----------------- 98
gi 229276106  22 ALFSVGYSVVFAGTVIGNLIVVVVIGRNRHlwgvTNTFIFNLALSDLLIAFFCIPFTLVNHifivdnnrslnlttevksc 101
gi 229290263  12 GLFIVSYGLVFLFSLGGNVGLCIVVLKYPRlrtvTNYFLLNLAVGDIMVTVCCMPFTLVDNil----------------- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             ###### ##  #                                          # ###
gi 13878604  211 ------------agWPFGntmCKISGLVQGISVAASVFTLVAIAVDRFQCVVypfkPKLTIkTAFVIIMIIWVLAITIMS 278
gi 13878599  107 ------------tgWPFDnatCKMSGLVQGMSVSASVFTLVAIAVERFRCIVhpfrEKLTLrKALVTIAVIWALALLIMC 174
gi 229296309  71 ------------lgWPFGdvmCRLVPFMQTTSVIASVFTLLAIAVDRFYAVVlptkPKLSVsQMVKAVTTIWVFALSVSL 138
gi 229281414  93 rliktlykvylsvpYQFGdvmCRVTPMIQGISVAASAYTMTAIAYDRYKAIVfptePRMSLgKMRNALAGIWIGAVAVMV 172
gi 229281300 197 ------------teNQFGdglCKFTPLIQGVAIGASVFTLTAIALDRHRLIIhpteRKLTVkEAFGIITAIWIFSLTIMI 264
gi 229296253 101 ------------veYQFGdfmCRLTALIQGLSVAASIYTLTAIAADRYKAILfphdGPMSIdTMKKVLVSIWVASLVVMV 168
gi 229281406  99 ------------kgWPFGgfmCRLSPAAAIISVAASVFTLVAIALDRYYAVLyptvSKFTVkSTIWTIRLIWFLAIIIGI 166
gi 229289971  99 ------------teNYLGdvmCKVSPMLQGMSVATSVFTLTAIAFDRYCVIVhptrDRLTVrQAVYLIIAIWVVAAIIMA 166
gi 229276106 102 ktcsvdkylltltkNVFGdamCRVKALAQGLSVGASVFTLTSIAADRYVVIVhphrERLTNnQALWVIFGVWIASAAIMA 181
gi 229290263  75 ------------vgYAFSeaiCRLSRMIEGVSVAASVLGLSAVAFYRYRAIVhpqkPKMTRrRAYQLIVISWLVSLFIML 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##                                     #  ### ### ##                            
gi 13878604  279 PSAVMlhvqeekyyrvrlnsqnktspvyWCREdwpnqemRKIYTTVLFANIYLAPLSLIVIMYGRIGISLfraavphtgr 358
gi 13878599  175 PSAVTltvtreehhfm-vdarnrsyplySCWEawpekgmRRVYTTVLFSHIYLAPLALIVVMYARIARKLcqapgpapgg 253
gi 229296309 139 PLIIFkhdteypdp-----egdviflvhYCDEqwpagdvSKYYSLSLFILSYLVPLGIILVLYVLIGHRIwfkatpgvqk 213
gi 229281414 173 PQVFVlhvkpipi--------mstvsinICVEtwpdivyKKTYTFMLFSLVYVGPLVVICFLYCRIWYKLaktpscavdd 244
gi 229281300 265 PQVFIrrdevim---------ilghgmhICGEfwpsveaKQIYSGFLFVLCYMGPLLLNACLYVKIGLTLwykkpvvk-- 333
gi 229296253 169 PQVFViqvrdssf-------miqdqhvdRCVEvwpdlvyKKIYSVTVVMLIYILPLMVMSFLYVRIAKKIwfqadlqrgs 241
gi 229281406 167 PVMIVmgpldgg---------drfsgtqMCVEhwptddyRRAFTVSLLLVCFLLPLSIIGYLYVRIGYRIwfsmtpgqtk 237
gi 229289971 167 PQAIVrrdesfq---------fgelnlsVCGEfwpspllRKAYSAFLFVICYAAPVLINTFLYGRTGYKLwmtksaaa-- 235
gi 229276106 182 PQAAVshekeil---------fenqtfdICGEfwpseasRQGYTAALFVLCYVAPLVAISLLYSKIAAKVwfkprpgaad 252
gi 229290263 143 PMAFVlngeylq---------yegykvyICKEewptieyNQAFTTTLFVFVYFLPVMSMAVMYGEVSRKLwgrqqvsrs- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                           #  ## ##  #             ## ###  #  ##        
gi 13878604  359 -----knqeqwhvvsRKKQKIIKMLLIVALLFILSWLPLWTLMMLSdyadlspnelqiiNIYIYPFAHWLAFGNSSVNPI 433
gi 13878599  254 ------eeaadprasRRRARVVHMLVMVALFFTLSWLPLWALLLLIdygqlsapqlhlvTVYAFPFAHWLAFFNSSANPI 327
gi 229296309 214 -----asmeaqnialQKKRKVVKMLIVVVVVFALFWLPLHTTLLLNdfvqlsylqrqvmYIYIFPIAHWLSYFNSSVNPI 288
gi 229281414 245 -----pqhasqfavsKKRVRVLKMLITVVVLFALSWLPLYTCWMLGdfanltkkqsgvmHQYVYPVAHWLGYSNSCANPI 319
gi 229281300 334 -------tpmaaadaKKKRRVVKMLIMIVSHFALSWLPLYTCWMLDdfnalsvshsetmHDYVYPAAHWLAFTNSVVNPI 406
gi 229296253 242 gsdtvrrrefigsvpKRRKRVIKMLIVVVTLFMVSWLPLYTCWMLDefgnmpnwqveivHQYVYPFAHWLSYFNSCVNPI 321
gi 229281406 238 -----ashdarasvtKRKTKVVKMLLVVVVLFTVTWLPLHIVMMLGdfgnlsrkqqhdlWIYVFPVAHWLSYIHSAMDPL 312
gi 229289971 236 -------pkacsnqtEQRSRIIKMMVIIVAVFAITWMPLYSCWLLEdfgqlthdqsamlHSYIYPIAHVMAFANSAVDPF 308
gi 229276106 253 g---gsrnpvpvgvsACRMRVIRMTITLVVVFATTWMPLYISTLLEdfgnlspqqqanlHHYVYPTAHLIAYANSFINPL 329
gi 229290263 213 -------sqrysdraRKRAQVTKMLIMIVVLFALSWLPLWVLQFLQvfghipeyimrvlLVYVVPVAHWLGYCNCLVNPI 285
                        330
                 ....*....|...
Feature 1                     
gi 13878604  434 IYGFFNenFRRGF 446
gi 13878599  328 IYGYFNenFRRGF 340
gi 229296309 289 IYGYFNpnFRDGF 301
gi 229281414 320 VYGFFNtnIRNNL 332
gi 229281300 407 VYGYFNnhLRENF 419
gi 229296253 322 VYGLFNrdIRKNV 334
gi 229281406 313 IYGYYNraVRTEF 325
gi 229289971 309 IYGLYSsnLRSRV 321
gi 229276106 330 VYGLFTtnFRQHF 342
gi 229290263 286 VYGYFNrdIRRQL 298

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