Conserved Protein Domain Family
7tmA_SREB1_GPR27

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cd15216: 7tmA_SREB1_GPR27 
super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors
The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320344
View PSSM: cd15216
Aligned: 3 rows
Threshold Bit Score: 485.299
Threshold Setting Gi: 15214047
Created: 28-Mar-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##               ####
gi 15214047  19 GLKLATLSLLLCVSLAGNVLFALLIVRERSlhraPYYLLLDLCLADGLRALACLPAVMLAARRaaaaaGAPPGalgCKLL 98
gi 15214036  22 GLRLATLSLLLCVSLAGNVLFALLIVRERSlhraPYYLLLDLCLADGLRALACLPAVMLAARRaaaaaGTPPGalgCKLL 101
gi 15214034  20 GLRLATLSLLLCVSLAGNVLFALLIVRERSlhraPYYLLLDLCLADGLRALACLPAVMLAARRaaaaaGTPPGalgCKLL 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       ## ##  #                                             # #####                    
gi 15214047  99 AFLAALFCFHAAFLLLGVGVTRYLAIAhhrFYAERLagWPCAAMLVCAAWALALAAAFPPVLDgg-gDDEDAPCALEQRp 177
gi 15214036 102 AFLAALFCFHAAFLLLGVGVTRYLAIAhhrFYAERLagWPCAAMLVCAAWALALAAAFPPVLDgggaDDEDAPCALEQRp 181
gi 15214034 100 AFLAALFCFHAAFLLLGVGVTRYLAIAhhrFYAERLagWPCAAMLVCAAWALALAAAFPPVLDgggaDDEDAPCALEQRp 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #  ### ### ##                                                                   
gi 15214047 178 DGAPGALGFLLLLAVVVGATHLVYLRLLFFihdrRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVG 257
gi 15214036 182 DGAPGALGFLLLLAAVVGATHLVYLRLLFFihdrRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVG 261
gi 15214034 180 DGAPGALGFLLLLAAVVGATHLVYLRLLFFihdrRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVG 259
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                              #  ## ##  #        ## ###  #  ##         
gi 15214047 258 IRpagpgrgARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLvrpgavPQAYLTASVWLTFAQAGINPVV 337
gi 15214036 262 IRpagpgrgARRLLVLEEFKTEKRLCKMFYAITLLFLLLWGPYVVASYLRVLvrpgavPQAYLTASVWLTFAQAGINPVV 341
gi 15214034 260 IRpagpgrgARRLLVLEEFKTEKRLCKMFYAITLLFLLLWGPYVVASYLRVLvrpgavPQAYLTASVWLTFAQAGINPVV 339
                       330
                ....*....|..
Feature 1                   
gi 15214047 338 CFLFNRELRDCF 349
gi 15214036 342 CFLFNRELRDCF 353
gi 15214034 340 CFLFNRELRDCF 351

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